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Volumn 110, Issue 31, 2013, Pages 12637-12642

Syntaxin1a variants lacking an N-peptide or bearing the LE mutation bind to Munc18a in a closed conformation

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE PROTEIN; MUNC18A PROTEIN; SNARE PROTEIN; SYNTAXIN 1A; UNCLASSIFIED DRUG;

EID: 84881097101     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1303753110     Document Type: Article
Times cited : (50)

References (32)
  • 1
    • 41949130893 scopus 로고    scopus 로고
    • Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide
    • Burkhardt P, Hattendorf DA, Weis WI, Fasshauer D (2008) Munc18a controls SNARE assembly through its interaction with the syntaxin N-peptide. EMBO J 27(7):923-933.
    • (2008) EMBO J , vol.27 , Issue.7 , pp. 923-933
    • Burkhardt, P.1    Hattendorf, D.A.2    Weis, W.I.3    Fasshauer, D.4
  • 2
    • 0034704771 scopus 로고    scopus 로고
    • Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex
    • Misura KM, Scheller RH, Weis WI (2000) Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex. Nature 404(6776):355-362.
    • (2000) Nature , vol.404 , Issue.6776 , pp. 355-362
    • Misura, K.M.1    Scheller, R.H.2    Weis, W.I.3
  • 3
    • 79551637409 scopus 로고    scopus 로고
    • Possible roles for Munc18-1 domain 3a and syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation
    • Hu S-H, et al. (2011) Possible roles for Munc18-1 domain 3a and syntaxin1 N-peptide and C-terminal anchor in SNARE complex formation. Proc Natl Acad Sci USA 108(3):1040-1045.
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.3 , pp. 1040-1045
    • Hu, S.-H.1
  • 4
    • 33845987734 scopus 로고    scopus 로고
    • Selective activation of cognate SNAREpins by Sec1/Munc18 proteins
    • Shen J, Tareste DC, Paumet F, Rothman JE, Melia TJ (2007) Selective activation of cognate SNAREpins by Sec1/Munc18 proteins. Cell 128(1):183-195.
    • (2007) Cell , vol.128 , Issue.1 , pp. 183-195
    • Shen, J.1    Tareste, D.C.2    Paumet, F.3    Rothman, J.E.4    Melia, T.J.5
  • 5
    • 77954715092 scopus 로고    scopus 로고
    • SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion
    • Shen J, Rathore SS, Khandan L, Rothman JE (2010) SNARE bundle and syntaxin N-peptide constitute a minimal complement for Munc18-1 activation of membrane fusion. J Cell Biol 190(1):55-63.
    • (2010) J Cell Biol , vol.190 , Issue.1 , pp. 55-63
    • Shen, J.1    Rathore, S.S.2    Khandan, L.3    Rothman, J.E.4
  • 6
    • 78651078463 scopus 로고    scopus 로고
    • Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex
    • Rathore SS, et al. (2010) Syntaxin N-terminal peptide motif is an initiation factor for the assembly of the SNARE-Sec1/Munc18 membrane fusion complex. Proc Natl Acad Sci USA 107(52):22399-22406.
    • (2010) Proc Natl Acad Sci USA , vol.107 , Issue.52 , pp. 22399-22406
    • Rathore, S.S.1
  • 7
    • 80052247975 scopus 로고    scopus 로고
    • Resolving the function of distinct Munc18-1/SNARE protein interaction modes in a reconstituted membrane fusion assay
    • Schollmeier Y, Krause JM, Kreye S, Malsam J, Söllner TH (2011) Resolving the function of distinct Munc18-1/SNARE protein interaction modes in a reconstituted membrane fusion assay. J Biol Chem 286(35):30582-30590.
    • (2011) J Biol Chem , vol.286 , Issue.35 , pp. 30582-30590
    • Schollmeier, Y.1    Krause, J.M.2    Kreye, S.3    Malsam, J.4    Söllner, T.H.5
  • 8
    • 0035913332 scopus 로고    scopus 로고
    • An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming
    • Richmond JE, Weimer RM, Jorgensen EM (2001) An open form of syntaxin bypasses the requirement for UNC-13 in vesicle priming. Nature 412(6844):338-341.
    • (2001) Nature , vol.412 , Issue.6844 , pp. 338-341
    • Richmond, J.E.1    Weimer, R.M.2    Jorgensen, E.M.3
  • 9
    • 0033575749 scopus 로고    scopus 로고
    • A conformational switch in syntaxin during exocytosis: Role of munc18
    • Dulubova I, et al. (1999) A conformational switch in syntaxin during exocytosis: Role of munc18. EMBO J 18(16):4372-4382.
    • (1999) EMBO J , vol.18 , Issue.16 , pp. 4372-4382
    • Dulubova, I.1
  • 10
    • 0035793377 scopus 로고    scopus 로고
    • Control of fusion pore dynamics during exocytosis by Munc18
    • Fisher RJ, Pevsner J, Burgoyne RD (2001) Control of fusion pore dynamics during exocytosis by Munc18. Science 291(5505):875-878.
    • (2001) Science , vol.291 , Issue.5505 , pp. 875-878
    • Fisher, R.J.1    Pevsner, J.2    Burgoyne, R.D.3
  • 11
    • 84862561705 scopus 로고    scopus 로고
    • Low-resolution solution structures of Munc18:Syntaxin protein complexes indicate an open binding mode driven by the syntaxin N-peptide
    • Christie MP, et al. (2012) Low-resolution solution structures of Munc18:Syntaxin protein complexes indicate an open binding mode driven by the syntaxin N-peptide. Proc Natl Acad Sci USA 109(25):9816-9821.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.25 , pp. 9816-9821
    • Christie, M.P.1
  • 12
    • 3543025090 scopus 로고    scopus 로고
    • Syntaxin/Munc18 interactions in the late events during vesicle fusion and release in exocytosis
    • Graham ME, Barclay JW, Burgoyne RD (2004) Syntaxin/Munc18 interactions in the late events during vesicle fusion and release in exocytosis. J Biol Chem279(31):32751-32760.
    • (2004) J Biol Chem , vol.279 , Issue.31 , pp. 32751-32760
    • Graham, M.E.1    Barclay, J.W.2    Burgoyne, R.D.3
  • 13
    • 84872866275 scopus 로고    scopus 로고
    • Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion
    • Zhou P, et al. (2013) Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion. EMBO J 32(1):159-171.
    • (2013) EMBO J , vol.32 , Issue.1 , pp. 159-171
    • Zhou, P.1
  • 14
    • 84860511697 scopus 로고    scopus 로고
    • Munc18-1 mutations that strongly impair SNARE-complex binding support normal synaptic transmission
    • Meijer M, et al. (2012) Munc18-1 mutations that strongly impair SNARE-complex binding support normal synaptic transmission. EMBO J 31(9):2156-2168.
    • (2012) EMBO J , vol.31 , Issue.9 , pp. 2156-2168
    • Meijer, M.1
  • 15
    • 0034661479 scopus 로고    scopus 로고
    • The X-ray crystal structure of neuronal Sec1 from squid sheds new light on the role of this protein in exocytosis
    • Bracher A, Perrakis A, Dresbach T, Betz H, Weissenhorn W (2000) The X-ray crystal structure of neuronal Sec1 from squid sheds new light on the role of this protein in exocytosis. Structure 8(7):685-694.
    • (2000) Structure , vol.8 , Issue.7 , pp. 685-694
    • Bracher, A.1    Perrakis, A.2    Dresbach, T.3    Betz, H.4    Weissenhorn, W.5
  • 16
    • 0032472409 scopus 로고    scopus 로고
    • ROP, the Drosophila Sec1 homolog, interacts with syntaxin and regulates neurotransmitter release in a dosagedependent manner
    • Wu MN, Littleton JT, Bhat MA, Prokop A, Bellen HJ (1998) ROP, the Drosophila Sec1 homolog, interacts with syntaxin and regulates neurotransmitter release in a dosagedependent manner. EMBO J 17(1):127-139.
    • (1998) EMBO J , vol.17 , Issue.1 , pp. 127-139
    • Wu, M.N.1    Littleton, J.T.2    Bhat, M.A.3    Prokop, A.4    Bellen, H.J.5
  • 17
    • 85027945821 scopus 로고    scopus 로고
    • Munc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complex
    • Ma C, Li W, Xu Y, Rizo J (2011) Munc13 mediates the transition from the closed syntaxin-Munc18 complex to the SNARE complex. Nat Struct Mol Biol 18(5):542-549.
    • (2011) Nat Struct Mol Biol , vol.18 , Issue.5 , pp. 542-549
    • Ma, C.1    Li, W.2    Xu, Y.3    Rizo, J.4
  • 18
    • 51749100843 scopus 로고    scopus 로고
    • Conformational switch of syntaxin-1 controls synaptic vesicle fusion
    • Gerber SH, et al. (2008) Conformational switch of syntaxin-1 controls synaptic vesicle fusion. Science 321(5895):1507-1510.
    • (2008) Science , vol.321 , Issue.5895 , pp. 1507-1510
    • Gerber, S.H.1
  • 19
    • 43649085762 scopus 로고    scopus 로고
    • NMR analysis of the closed conformation of syntaxin-1
    • Chen X, Lu J, Dulubova I, Rizo J (2008) NMR analysis of the closed conformation of syntaxin-1. J Biomol NMR 41(1):43-54.
    • (2008) J Biomol NMR , vol.41 , Issue.1 , pp. 43-54
    • Chen, X.1    Lu, J.2    Dulubova, I.3    Rizo, J.4
  • 20
    • 40649084835 scopus 로고    scopus 로고
    • SNAREpin/Munc18 promotes adhesion and fusion of large vesicles to giantmembranes
    • Tareste DC, Shen J, Melia TJ, Rothman JE (2008) SNAREpin/Munc18 promotes adhesion and fusion of large vesicles to giantmembranes. Proc Natl Acad Sci USA 105(7):2380-2385.
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.7 , pp. 2380-2385
    • Tareste, D.C.1    Shen, J.2    Melia, T.J.3    Rothman, J.E.4
  • 21
    • 0028103275 scopus 로고
    • The CCP4 suite: Programs for protein crystallography
    • Collaborative Computational Project, Number 4
    • Collaborative Computational Project, Number 4 (1994) The CCP4 suite: Programs for protein crystallography. Acta Crystallogr D Biol Crystallogr 50(Pt 5):760-763.
    • (1994) Acta Crystallogr D Biol Crystallogr , vol.50 , Issue.PART 5 , pp. 760-763
  • 23
    • 34447508216 scopus 로고    scopus 로고
    • Phaser crystallographic software
    • McCoy AJ, et al. (2007) Phaser crystallographic software. J Appl Cryst 40:658-674.
    • (2007) J Appl Cryst , vol.40 , pp. 658-674
    • McCoy, A.J.1
  • 24
    • 14244272868 scopus 로고    scopus 로고
    • PHENIX: Building new software for automated crystallographic structure determination
    • Adams PD, et al. (2002) PHENIX: Building new software for automated crystallographic structure determination. Acta Crystallogr D Biol Crystallogr 58(Pt 11):1948-1954.
    • (2002) Acta Crystallogr D Biol Crystallogr , vol.58 , Issue.PART 11 , pp. 1948-1954
    • Adams, P.D.1
  • 25
    • 13244281317 scopus 로고    scopus 로고
    • Coot: Model-building tools for molecular graphics
    • Emsley P, Cowtan K (2004) Coot: Model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr 60(Pt 12 Pt 1):2126-2132.
    • (2004) Acta Crystallogr D Biol Crystallogr , vol.60 , Issue.PART 12 , pp. 2126-2132
    • Emsley, P.1    Cowtan, K.2
  • 26
    • 14844321328 scopus 로고    scopus 로고
    • Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNT
    • Blanc E, et al. (2004) Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNT. Acta Crystallogr D Biol Crystallogr 60(Pt 12 Pt 1):2210-2221.
    • (2004) Acta Crystallogr D Biol Crystallogr , vol.60 , Issue.PART 12 , pp. 2210-2221
    • Blanc, E.1
  • 27
    • 0028922586 scopus 로고
    • LIGPLOT: A program to generate schematic diagrams of protein-ligand interactions
    • Wallace AC, Laskowski RA, Thornton JM (1995) LIGPLOT: A program to generate schematic diagrams of protein-ligand interactions. Protein Eng 8(2):127-134.
    • (1995) Protein Eng , vol.8 , Issue.2 , pp. 127-134
    • Wallace, A.C.1    Laskowski, R.A.2    Thornton, J.M.3
  • 28
    • 77954522769 scopus 로고    scopus 로고
    • Phenix. Model-vs-data: A high-level tool for the calculation of crystallographic model and data statistics
    • Afonine PV, et al. (2010) phenix.model-vs-data: A high-level tool for the calculation of crystallographic model and data statistics. J Appl Cryst 43(Pt 4):669-676.
    • (2010) J Appl Cryst , vol.43 , Issue.PART 4 , pp. 669-676
    • Afonine, P.V.1
  • 29
    • 27144505097 scopus 로고    scopus 로고
    • Protein identification and analysis tools on the ExPASy server
    • ed Walker JM (Humana Press, Clifton, NJ)
    • Gasteiger E, et al. (2005) Protein identification and analysis tools on the ExPASy server. The Proteomics Handbook, ed Walker JM (Humana Press, Clifton, NJ), pp 571-607.
    • (2005) The Proteomics Handbook , pp. 571-607
    • Gasteiger, E.1
  • 30
    • 0029185933 scopus 로고
    • CRYSOL: A program to evaluate X-ray solution scattering of biological macromolecules from atomic coordinates
    • Svergun D, Barberato C, Koch MHJ (1995) CRYSOL: A program to evaluate X-ray solution scattering of biological macromolecules from atomic coordinates. J Appl Cryst 28:768-773.
    • (1995) J Appl Cryst , vol.28 , pp. 768-773
    • Svergun, D.1    Barberato, C.2    Koch, M.H.J.3
  • 31
    • 0026244044 scopus 로고
    • GNOM: A program package for small-angle scattering data processing
    • Semenyuk AV, Svergun DI (1991) GNOM: A program package for small-angle scattering data processing. J Appl Cryst 24:537-540.
    • (1991) J Appl Cryst , vol.24 , pp. 537-540
    • Semenyuk, A.V.1    Svergun, D.I.2
  • 32


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.