Protective effect on oxidative DNA damage and antiproliferative activity of standardized γ-oryzanol-rich extracts from Thai purple rice bran

Chiang Mai University Journal of Natural Sciences

Volumn 12, Issue 1, 2013, Pages 1-11

  Saenjum, Chalermpong ^a   Chaiyasut, Chaiyavat ^a   Chansakaow, Sunee ^a   Sirithunyalug, Busaban ^a  

^a CHIANG MAI UNIVERSITY   (Thailand)

Author keywords

Oryzanol; Antiproliferative activity; DNA damage; Thai purple rice bran

Indexed keywords

EID: 84881093988     PISSN: 16851994     EISSN: None     Source Type: Journal    
DOI: 10.12982/CMUJNS.2013.0001     Document Type: Article

References (18)

1. Awad, A.B., Y.C. Chen, C.S. Fink, and T. Hennessey. 1996. β-Sitosterol inhibits HT-29 human colon cancer cell growth and alters membrane lipids. Anticancer Res. 16: 2797-2804.
2. Awad, A.B., M. Chinman, C.S. Fink, and P.G. Bradford. 2007. β-Sitosterol activates Fas signaling in human breast cancer cells. Phytomedicine. 14: 747-754.
3. Chotimarkorn, C., S. Benjakul, and N. Silalai. Antioxidant components and properties of long-grained rice bran extracts from commercial available cultivars in Thailand. Food Chem. 111: 636-641.
4. Halliwell, B., and J.M.C. Gutterridge. 1990. Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol. 186: 1-85.
5. Hoeijmakers, J.H.J. 2009. Molecular origins of cancer: DNA damage, aging and cancer. New Engl. J. Med. 361: 1475-1485.
6. Hudson, E.A., P.A. Dinh, T. Kokubun, M.S.J. Simmonds, and Gescher A. 2009. Characterization of potentially chemopreventive phenols in extracts of brown rice that inhibit growth of human breast and colon cancer cells. Cancer Epidem. Biomar. 9: 1163-1170.
7. Jarray, R., B. Allain, L. Borriello, D. Biard, A. Loukaci, J. Larghero, R. Hadj-Slimane, C. Garbay, Y. Lepelletier, and F. Raynaud. 2011. Depletion of the novel protein PHACTR-1 from human endothelial cells abolishes tube formation and induces cell death receptor apoptosis. Biochimie. 93: 1668-1675.
8. Janicke, B., G. Onning, and S.M. Oredsson. 2005. Differential effects of ferulic acid and p-coumaric acid on S phase in human colonic cell line Caco-2. J. Agric. Food Chem. 53: 6658-6665.
9. Kim, Y.G., and H.Y. Park. 2004. The effects of pycnogenol on DNA damage in vitro and expression of superoxide dismutase and HP1 in Escherichia coli SOD and catalase deficient mutant cells. Phytother. Res. 18: 900-905.
10. Malekian, F., R.M. Rao, W. Prinyawiwatkul, W.E. Marshall, M. Windhauser, and M. Ahmedna. 2000. Lipase and lipoxygenase activity, functionality, and nutrient losses in rice bran during storage. LA. AES. BULL. 870: 1-68.
11. Nam, S.H., S.P. Chor, M.Y. Kang, N. Kozukue, and M. Friedman. 2005. Antioxidative, antimutagenic, and anticarcinogenic activities of rice bran extracts in chemical and cell assays. J. Agric. Food. Chem. 53: 816-822.
12. Poirier, M.C. 2004. Chemical-induced DNA damage and human cancer risk. Nature Review. 4: 630-637.
13. Saenjum, C., C. Chaiyasut, S. Kadchumsang, S. Chansakaow, and S. Suttajit. 2010. Antioxidant activity and protective effects on DNA damage of Caesalpinia sappan L. extract. J. Med. Plants Res. 4: 1594-1600.
14. Shahidi, F., and P.K.J.P.D. Wanasundara. 1992. Phenolic antioxidants. Crit. Rev. Food Sci. Nutr. 32: 67-103.
15. Srisala, S., R. Chunhabundit, R. Kongkachuichai, B. Jittorntrum, and Y. Visetpanit. 2009. Effects of bran extracts from Thai molecular breeding rices on growth and apoptosis in human promyelocytic leukemia cells. Thai J. Toxicol. 24(2): 81-91.
16. Williams, D.E., R.H. Dashwood, J.D. Hendricks, and G.S. Bailey. 1989. Anticarcinogens and tumor promoters in foods. In Food Toxicology-A Perspective on Relative Risks; Tayler, S.L., Scanlan, R.A., (eds), Marcal Dekker: New York.
17. Wiseman, H., and B. Halliwell. 1996. Damage of DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression of cancer. Biochem. J. 313: 17-29.
18. Xu, Z., and J.S. Godber. 1999. Purification and identification of components of γ-oryzanol in rice bran. J. Agric. Food Chem. 47: 2724-2728.