The effects of pycnogenol on DNA damage in vitro and expression of superoxide dismutase and HP1 in Escherichia coli SOD and catalase deficient mutant cells

Phytotherapy Research

Volumn 18, Issue 11, 2004, Pages 900-905

  Kim, Young Gon ^a   Park, Hyeon Yong ^a  

^a Chosun University   (South Korea)

Author keywords

Antioxidants; DNA damage; Fenton reaction; Free radicals; Pycnogenol

Indexed keywords

ALPHA TOCOPHEROL; BUTYLCRESOL; CATALASE; CURCUMIN; DEFEROXAMINE; DNA; HETEROCHROMATIN PROTEIN 1; PYCNOGENOL; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

AGAR GEL ELECTROPHORESIS; ANTIOXIDANT ACTIVITY; ARTICLE; BARK; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; DNA SUPERCOILING; DRUG EFFECT; ESCHERICHIA COLI; FENTON REACTION; IN VITRO STUDY; IN VIVO STUDY; IRON CHELATION; NONHUMAN; OXIDATIVE STRESS; PINE; PROTEIN EXPRESSION;

ANTIOXIDANTS; DNA DAMAGE; ESCHERICHIA COLI; FLAVONOIDS; HUMANS; HYDROGEN PEROXIDE; HYDROXYL RADICAL; IRON; PHYTOTHERAPY; PINUS; PLANT BARK; PLANT EXTRACTS; PLASMIDS; SUPEROXIDE DISMUTASE;

ESCHERICHIA COLI; PINUS PINASTER;

EID: 11144221253     PISSN: 0951418X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ptr.1538     Document Type: Article

References (38)

1. Aburto EM, Cribb A, Fuentealba IC, et al. 2001. The failure of selenium supplementation to prevent copper-induced liver damage in Fischer 344 rats. Can J Vet Res 65: 104-110.
2. Araghi-Niknam M, Hosseini S, Larson D, et al. 2000. Pine bark extract reduces platelet aggregation. Integr Med 2: 73-77.
3. Bayeta E, Benjamin HS. 2000. Pycnogenol inhibits generation of inflammatory mediators in macrophages. Nutrition Res 20: 249-259.
4. Beauchamp C, Fridovich I. 1971. Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Anal Biochem 44: 276-287
5. Birnboim HC, Jevycak JJ. 1981. Fluorometric method for rapid detection of DNA strand breaks in human white blood cells produced by low doses radiation. Cancer Res 41: 1889-1892.
6. Blazso G, Gabor M, Sibbel R, Rohdewald P. 1994. Antiinflammatory and superoxide radical scavenging activities of procyanidins containing extract from the bark of Pinus pinaster sol. and its fractions. Pharm Pharmacol Lett 3: 217-220.
7. Carlioz A, Touati D. 1986. Isolation of superoxide dismutase mutants in Escherichia coir. Is superoxide dismutase necessary for anaerobic life? EMBO J 5: 623-630.
8. Cho KJ, Yun CH, Yoon DY, et al. 2000. Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interleukin-1 production in lipopolysaccharide-stimulated RAW 264.7. Toxicol Appl Pharmacol 168: 64-71.
9. Claiborne A, Fridovich I. 1979. Purification of the orthodiansidine peroxidase from Escherichia coli B. J Biol Chem 254: 4245-4252.
10. Drai J, Bannier E, Chazot C, et al. 2001. Oxidants and antioxidants in long-term haemodialysis patients. Farmacol 56: 463-465.
11. Elstner, EF, Kleber E. 1990. Radical scavenger properties of leucocyanidin. In Flavonoids in Biology and Medicine. III. Current Issues in Flavonoid Research, Das, NP (ed.). National University of Singapore press: Singapore; 227-235.
12. Fitzpatrick DF, Bing B, Rohdewald P. 1998. Endothelium-dependent vascular effects of Pycnogenol. J Cardiovasc Pharmacol 32: 509-515.
13. Guo Q, Zhao B, Packer L. 1999. Electron spin resonance study of free radicals formed from a procyanidin-rich pine (Pinus maritima) bark extract, pycnogenol. Free Radic Biol Med 27: 1308-1312.
14. Hasegawa N. 2000. Inhibition of lipogenesis by pycnogenol. Phytother Res 14: 472-473.
15. Hermes-Lima M, Nagy E, Ponka P, Schulman HM. 1998. The iron chelator pyridoxal isonicotinoyl hydrazone (PIH) protects plasmid pUC-18 DNA against OH-mediated strand breaks. Free Radic Biol Med 25: 875-880.
16. Huynh HT, Teel RW. 2000. Selective induction of apoptosis in human mammary cancer cells (MCF-7) by pycnogenol. Anticancer Res 20: 2417-2420.
17. Kato T, Kojima K, Hiramoto K, Kikugawa, K. 1992. DNA strand breakage by hydroxyphenyl radicals generated from mutagenic diazoquinone compounds. Mutat Res 268: 105-114.
18. Kintzel PE. 2001. Anticancer drug-induced kidney disorders [review]. Drug Saf 24: 29-38.
19. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the folin phenol reagent. J Biol Chem 193: 65-275.
20. Macrides TA, Shihata A, Kalafatis N, Wright PF. 1997. A comparison of the hydroxyl radical scavenging properties of the shark bile steroid 5 beta-scymnol and plant pycnogenols. Biochem Mol Bio Int 42: 1249-1260.
21. Maffei Facino R, Carini M, Aldini G, et al. 1994. Free radicals scavenging action and anti-enzyme activities of procyanidines from Vitis vinifera. A mechanism for their capillary protective action. Arzneimittelforschung 44: 592-601.
22. McCord JM, Fridovich I. 1969. Superoxide dismutase, an enzymatic function for erythrocuprein (hemocuprein). J Biol Chem 244: 6049-6055.
23. Mino M. 1992. Clinical uses and abuses of vitamin E in children. Proc Soc Exp Biol Med 200: 266-270.
24. Noda Y, Anzai K, Mori A, et al. 1997. Hydroxyl and superoxide anion radical scavenging activities of natural source anti-oxidants using the computerized JES-FR30 ESR spectrometer system. Biochem Mol Biol Int 42: 35-44.
25. Ohnishi ST, Ohnishi T, Ogunmola GB. 2000. Sickle cell anemia: a potential nutritional approach for a molecular disease. Nutrition 16: 330-338.
26. Ozhogina OA, Kasaikina OT. 1995. Beta-carotene as an interceptor of free radicals. Free Radic Biol Med 19: 575-581.
27. Packer L, Rimbach G, Virgili F. 1999. Antioxidant activity and biologic properties of a procyanidin-rich extract from pine (Pinus maritime) bark, pycnogenol. Free Radic Biol Med 27: 704-724.
28. Park HY, Kim YG. 1998. Response of CuZnSOD and HP1 conjugated gene in Escherichia coli double mutants to oxidative stress. J Microbiology 36: 171-178.
29. Peng Q, Wei Z, Lau BH. 2000. Pycnogenol inhibits tumor necrosis factor-alpha-induced nuclear factor kappa B activation and adhesion molecule expression in human vascular endothelial cells. Cell Mol Life Sci 57: 834-841.
30. Petrassi C, Mastromarino A, Spartera C. 2000. Pycnogenol in chronic venous insufficiency. Phytomedicine 7: 383-388.
31. Rice-Evans CA, Diplock AT. 1993. Current status of antioxidant therapy [review]. Free Radic Biol Med 15: 77-96.
32. Saito I, Kawabata M, Fujiwara T, Matsura T. 1989. A novel ribose C-4′ hydroxylation pathway in neocarzinostatin mediated degradation of oligonucleotides. J Am Chem Soc III: 8302-8304.
33. Saliou C, Rimbach G, Moini H, et al. 2001. Solar ultraviolet-induced erythema in human skin and nuclear factor-kappa-B-dependent gene expression in keratinocytes are modulated by a French maritime pine bark extract. Free Radic Biol Med 30: 154-160.
34. Sambrook J, Fritsch EF, Maniatis T. 1989. Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor Lab: New York, USA; 1.3-L47.
35. Tixier JM, Godeau G, Robert AM, Hornebeck W. 1984. Evidence by in vivo and in vitro studies that binding of pycnogenols to elastin affects its rate of degradation by elastases. Biochem Pharmacol. 33: 3933-3939.
36. van Jaarsveld H, Kuyl JM, Schulenburg DH, Wild NM. 1996. Effect of flavonoids on the outcome of myocardial mitochondrial ischemia/reperfusion injury. Res Commun Mol Pathol Pharmacol 91: 65-75.
37. Virgili F, Kobuchi H, Packer L. 1998. Procyanidins extracted from Pinus maritime (Pycnogenol): scavengers of free radical species and modulators of nitrogen monoxide metabolism in activated murine RAW 264.7 macrophages. Free Radic Biol Med 24: 1120-1129.
38. Wojtukiewicz MZ, Omyla J, Kozlowski L, Szynaka B. 2000. Cardiotoxicity of anthracycline [review]. Postepy Hig Med Dosw 54: 467-485.