Conjugation to polymeric chains of influenza drugs targeting M2 ion channels partially restores inhibition of drug-resistant mutants

Journal of Pharmaceutical Sciences

Volumn 102, Issue 8, 2013, Pages 2450-2459

  Larson, Alyssa M ^a   Chen, Jianzhu ^a   Klibanov, Alexander M ^a,b  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Antiinfectives; Biodegradable polymers; Conjugation; Drug resistance; Inhibition; Polymeric drug carrier; Polymeric drugs; Polymers

Indexed keywords

AMANTADINE; AZIDE; DRUG CARRIER; INFLUENZA VACCINE; POLYLACTIC ACID; POLYMER; RIMANTADINE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M2; ZANAMIVIR;

ANIMAL CELL; ANIMAL CELL CULTURE; ANTIVIRAL RESISTANCE; ARTICLE; DRUG CONJUGATION; DRUG STRUCTURE; DRUG TARGETING; INFLUENZA VIRUS; MDCK CELL; NONHUMAN; POLYMERIZATION; SYNTHESIS; VIRION; VIRUS INHIBITION; VIRUS MUTANT; VIRUS STRAIN;

EID: 84881022274     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23644     Document Type: Article

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