Conjugating drug candidates to polymeric chains does not necessarily enhance anti-influenza activity

Journal of Pharmaceutical Sciences

Volumn 101, Issue 10, 2012, Pages 3896-3905

  Larson, Alyssa M ^a   Wang, Hongmei ^b   Cao, Yang ^c   Jiang, Taijiao ^d   Chen, Jianzhu ^a   M Klibanov, Alexander ^a,e  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b CHINA AGRICULTURAL UNIVERSITY   (China)

^c SICHUAN UNIVERSITY   (China)

^d INSTITUTE OF BIOPHYSICS   (China)

^e Massachusetts Institute of Technology   (United States)

Author keywords

Anti infectives; Conjugation; Drug design; Influenza; Inhibitor; Polymeric drug carrier; Polymeric drugs; Structure activity relationship

Indexed keywords

ANTIVIRUS AGENT; BENZOQUINONE; HYDROQUINONE; OSELTAMIVIR; POLYGLUTAMIC ACID; POLYMER; SIALIC ACID; ZANAMIVIR;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; AVIAN INFLUENZA VIRUS; COMPARATIVE STUDY; DRUG CONJUGATION; DRUG DETERMINATION; DRUG POTENCY; INFLUENZA VIRUS A; NONHUMAN; STRUCTURE ACTIVITY RELATION;

EID: 84865401137     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23253     Document Type: Article

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