Molecular mechanisms involved in the protective effect of selenocystine against methylmercury-induced cell death in human HepG2 cells

Food and Chemical Toxicology

Volumn 59, Issue , 2013, Pages 554-563

  Cordero Herrera, Isabel ^a   Cuello, Susana ^b   Goya, Luis ^a   Madrid, Yolanda ^b   Bravo, Laura ^a   Cámara, Carmen ^b   Ramos, Sonia ^a  

^a INSTITUTE OF FOOD SCIENCE   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Antioxidant and detoxificant defences; Cell death; HepG2 cells; Methylmercury; Selenocystine

Indexed keywords

ANTIOXIDANT; CASPASE 3; GLUTATHIONE; GLUTATHIONE REDUCTASE; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE P38; ORGANOSELENIUM DERIVATIVE; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SE METHYLSELENOCYSTEINE; SELENIUM METHIONINE; SELENOCYSTINE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL PROTECTION; CELL STRAIN HEPG2; CELL STRESS; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME REGULATION; HUMAN; HUMAN CELL; OXIDATION REDUCTION STATE;

5-BROMO-2′-DEOXYURIDINE; ANTIOXIDANT AND DETOXIFICANT DEFENCES; BRDU; C-JUN N-TERMINAL KINASE; CAT; CATALASE; CELL DEATH; DITHIOTREITOL; DTT; ERK; EXTRACELLULAR REGULATED KINASE; FBS; FETAL BOVINE SERUM; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GPX; GR; GSH; HEPG2 CELLS; JNK; LACTATE DEHYDROGENASE; LDH; MAPK; MEHG; METHYLMERCURY; MITOGEN-ACTIVATED PROTEIN KINASES; REACTIVE OXYGEN SPECIES; ROS; SECYS; SELENIUM METHYLSELENOCYSTEINE; SELENOCYSTINE; SELENOMETHIONINE; SEMESECYS; SEMET;

APOPTOSIS; CELL PROLIFERATION; CELL SURVIVAL; CYSTINE; ENVIRONMENTAL POLLUTANTS; GLUTATHIONE; HEP G2 CELLS; HEPATOCYTES; HUMANS; MAP KINASE SIGNALING SYSTEM; METHYLMERCURY COMPOUNDS; ORGANOSELENIUM COMPOUNDS; OSMOLAR CONCENTRATION; OXIDATION-REDUCTION; OXIDATIVE STRESS; OXIDOREDUCTASES; PROTECTIVE AGENTS; REACTIVE OXYGEN SPECIES; SELENOCYSTEINE; SELENOMETHIONINE;

EID: 84881017025     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2013.06.057     Document Type: Article

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