메뉴 건너뛰기




Volumn 94, Issue 2, 2013, Pages 377-383

Regulatory T cell epitopes (Tregitopes) in IgG induce tolerance in vivo and lack immunogenicity per se

Author keywords

Immunomodulation; IVIg; Treg

Indexed keywords

EPITOPE; IMMUNOGLOBULIN G;

EID: 84880992500     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.0912441     Document Type: Article
Times cited : (35)

References (37)
  • 1
    • 0037364804 scopus 로고    scopus 로고
    • Natural versus adaptive regulatory T cells
    • Bluestone, J. A., Abbas, A. K (2003) Natural versus adaptive regulatory T cells. Nat. Rev. Immunol. 3, 253-257.
    • (2003) Nat. Rev. Immunol , vol.3 , pp. 253-257
    • Bluestone, J.A.1    Abbas, A.K.2
  • 2
    • 39449126502 scopus 로고    scopus 로고
    • The Foxp3+ regulatory T cell: A jack of all trades, master of regulation
    • Tang, Q., Bluestone, J. A. (2008) The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat. Immunol. 9, 239-244.
    • (2008) Nat. Immunol , vol.9 , pp. 239-244
    • Tang, Q.1    Bluestone, J.A.2
  • 3
    • 0038434099 scopus 로고    scopus 로고
    • Immune dysregula-tion, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis
    • Gambineri, E., Torgerson, T. R., Ochs, H. D. (2003) Immune dysregula-tion, polyendocrinopathy, enteropathy, and X-linked inheritance (IPEX), a syndrome of systemic autoimmunity caused by mutations of FOXP3, a critical regulator of T-cell homeostasis. Curr. Opin. Rheumatol. 15, 430-435.
    • (2003) Curr. Opin. Rheumatol , vol.15 , pp. 430-435
    • Gambineri, E.1    Torgerson, T.R.2    Ochs, H.D.3
  • 4
    • 0036669298 scopus 로고    scopus 로고
    • CD4 regulatory T cells prevent lethal autoimmunity in IL-2R/3-deficient mice. Implications for the nonredundant function of IL-2
    • Malek, T. R., Yu, A, Vincek, V., Scibelli, P., Kong, L. (2002) CD4 regulatory T cells prevent lethal autoimmunity in IL-2R/3-deficient mice. Implications for the nonredundant function of IL-2. Immunity 17, 167-178.
    • (2002) Immunity , vol.17 , pp. 167-178
    • Malek, T.R.1    Yu, A.2    Vincek, V.3    Scibelli, P.4    Kong, L.5
  • 5
    • 33846485153 scopus 로고    scopus 로고
    • Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
    • Kim, J. M., Rasmussen, J. P., Rudensky, A. Y. (2007) Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat. Immunol. 8, 191-197.
    • (2007) Nat. Immunol , vol.8 , pp. 191-197
    • Kim, J.M.1    Rasmussen, J.P.2    Rudensky, A.Y.3
  • 7
    • 34248207245 scopus 로고    scopus 로고
    • Monoclonal antibody and intravenous immunoglobulin therapy for rheumatic diseases: Rationale and mechanisms of action
    • Bayry, J., Lacroix-Desmazes, S., Kazatchkine, M. D., Kaveri, S. V. (2007) Monoclonal antibody and intravenous immunoglobulin therapy for rheumatic diseases: rationale and mechanisms of action. Nature clinical practice. Rheumatology 3, 262-272.
    • (2007) Nature Clinical Practice. Rheumatology , vol.3 , pp. 262-272
    • Bayry, J.1    Lacroix-Desmazes, S.2    Kazatchkine, M.D.3    Kaveri, S.V.4
  • 9
    • 42649089750 scopus 로고    scopus 로고
    • Anti-inflammatory actions of intravenous immunoglobulin
    • Nimmerjahn, F., Ravetch, J. V. (2008) Anti-inflammatory actions of intravenous immunoglobulin. Annu. Rev. Immunol. 26, 513-533.
    • (2008) Annu. Rev. Immunol , vol.26 , pp. 513-533
    • Nimmerjahn, F.1    Ravetch, J.V.2
  • 13
    • 35348957966 scopus 로고    scopus 로고
    • Tolerance induction by gene transfer to lymphocytes
    • Skupsky, J., Su, Y, Lei, T. C, Scott, D. W. (2007) Tolerance induction by gene transfer to lymphocytes. Curr. Gene. Ther. 7, 369-380.
    • (2007) Curr. Gene. Ther , vol.7 , pp. 369-380
    • Skupsky, J.1    Su, Y.2    Lei, T.C.3    Scott, D.W.4
  • 14
    • 84861130494 scopus 로고    scopus 로고
    • B-cell based gene therapy for autoimmune diseases
    • Scott, D. W., Zhang, A. H., Su, Y (2012) B-cell based gene therapy for autoimmune diseases. Infect. Dis. Drug Targets 12, 241-247.
    • (2012) Infect. Dis. Drug Targets , vol.12 , pp. 241-247
    • Scott, D.W.1    Zhang, A.H.2    Su, Y.3
  • 15
    • 20444476217 scopus 로고    scopus 로고
    • Induction of tolerance to factor VIII inhibitors by gene therapy with immunodominant A2 and C2 domains presented by B cells as Ig fusion proteins
    • Lei, T. C, Scott, D. W. (2005) Induction of tolerance to factor VIII inhibitors by gene therapy with immunodominant A2 and C2 domains presented by B cells as Ig fusion proteins. Blood 105, 4865-4870.
    • (2005) Blood , vol.105 , pp. 4865-4870
    • Lei, T.C.1    Scott, D.W.2
  • 16
    • 33747842285 scopus 로고    scopus 로고
    • Treatment of diabetes in NOD mice by gene transfer of Ig-fusion proteins into B cells: Role of T regulatory cells
    • Soukhareva, N., Jiang, Y, Scott, D. W. (2006) Treatment of diabetes in NOD mice by gene transfer of Ig-fusion proteins into B cells: role of T regulatory cells. Cell. Immunol. 240, 41-46.
    • (2006) Cell. Immunol , vol.240 , pp. 41-46
    • Soukhareva, N.1    Jiang, Y.2    Scott, D.W.3
  • 20
    • 84878135799 scopus 로고    scopus 로고
    • Application of IgG-derived natural Treg epitopes (IgG Tregitopes) to antigen-specific tolerance induction in a murine model of type 1 diabetes
    • [Epub ahead of print]
    • Cousens, L. P., Su, Y, McClainea, E., Li, X., Terry, F., Smith, R, Leed, J., Martina, W., Scott, D. W., De Groot, A. S. (2013) Application of IgG-derived natural Treg epitopes (IgG Tregitopes) to antigen-specific tolerance induction in a murine model of type 1 diabetes. J. Diabetes Res. doi: http://dx.doi.org/10.1155/2013/621693 [Epub ahead of print].
    • (2013) J. Diabetes Res
    • Cousens, L.P.1    Su, Y.2    McClainea, E.3    Li, X.4    Terry, F.5    Smith, R.6    Leed, J.7    Martina, W.8    Scott, D.W.9    de Groot, A.S.10
  • 21
    • 0029995883 scopus 로고    scopus 로고
    • Epitope-specific tolerance induction with an engineered immunoglobulin
    • Zambidis, E. T., Scott, D. W. (1996) Epitope-specific tolerance induction with an engineered immunoglobulin. Proc. Natl. Acad. Sci. USA 93, 5019-5024.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 5019-5024
    • Zambidis, E.T.1    Scott, D.W.2
  • 22
    • 0031093505 scopus 로고    scopus 로고
    • Both resting and activated B lymphocytes expressing engineered peptide-Ig molecules serve as highly efficient tolerogenic vehicles in immunocompetent adult recipients
    • Zambidis, E. T., Barth, R K, Scott, D. W. (1997) Both resting and activated B lymphocytes expressing engineered peptide-Ig molecules serve as highly efficient tolerogenic vehicles in immunocompetent adult recipients. J. Immunol. 158, 2174-2182.
    • (1997) J. Immunol , vol.158 , pp. 2174-2182
    • Zambidis, E.T.1    Barth, R.K.2    Scott, D.W.3
  • 23
    • 0036569428 scopus 로고    scopus 로고
    • Gene transfer of Ig-fusion proteins into B cells prevents and treats autoimmune diseases
    • Melo, M. E., Qian, J., El-Amine, M., Agarwal, R K, Soukhareva, N., Kang, Y, Scott, D. W. (2002) Gene transfer of Ig-fusion proteins into B cells prevents and treats autoimmune diseases. J. Immunol. 168, 4788-4795.
    • (2002) J. Immunol , vol.168 , pp. 4788-4795
    • Melo, M.E.1    Qian, J.2    El-Amine, M.3    Agarwal, R.K.4    Soukhareva, N.5    Kang, Y.6    Scott, D.W.7
  • 24
    • 1842685036 scopus 로고    scopus 로고
    • A novel retroviral gene therapy approach to inhibit specific antibody production and suppress experimental autoimmune encephalomyelitis induced by MOG and MBP
    • Xu, B., Scott, D. W. (2004) A novel retroviral gene therapy approach to inhibit specific antibody production and suppress experimental autoimmune encephalomyelitis induced by MOG and MBP. Clin. Immunol. 111, 47-52.
    • (2004) Clin. Immunol , vol.111 , pp. 47-52
    • Xu, B.1    Scott, D.W.2
  • 25
    • 77955918711 scopus 로고    scopus 로고
    • B-cell delivered gene therapy for tolerance induction: Role of autoantigen-specific B cells
    • Zhang, A. H., Li, X., Onabajo, O. O., Su, Y, Skupsky, J., Thomas, J. W., Scott, D. W. (2010) B-cell delivered gene therapy for tolerance induction: role of autoantigen-specific B cells. J. Autoimmun. 35, 107-113.
    • (2010) J. Autoimmun , vol.35 , pp. 107-113
    • Zhang, A.H.1    Li, X.2    Onabajo, O.O.3    Su, Y.4    Skupsky, J.5    Thomas, J.W.6    Scott, D.W.7
  • 26
    • 0033927572 scopus 로고    scopus 로고
    • Retroviral gene therapy with an immunoglobulin-antigen fusion construct protects from experimental autoimmune uveitis
    • Agarwal, R K, Kang, Y, Zambidis, E., Scott, D. W., Chan, C. C, Caspi, R R (2000) Retroviral gene therapy with an immunoglobulin-antigen fusion construct protects from experimental autoimmune uveitis. J. Clin. Invest. 106, 245-252.
    • (2000) J. Clin. Invest , vol.106 , pp. 245-252
    • Agarwal, R.K.1    Kang, Y.2    Zambidis, E.3    Scott, D.W.4    Chan, C.C.5    Caspi, R.R.6
  • 29
    • 84863569144 scopus 로고    scopus 로고
    • Potential application of Tregitopes as immunomodulating agents in multiple sclerosis
    • Elyaman, W., Khoury, S. J., Scott, D. W., De Groot, A. S. (2011) Potential application of Tregitopes as immunomodulating agents in multiple sclerosis. Neurol. Res. Int. 2011, 256460.
    • (2011) Neurol. Res. Int , vol.2011 , pp. 256460
    • Elyaman, W.1    Khoury, S.J.2    Scott, D.W.3    de Groot, A.S.4
  • 31
    • 75749087940 scopus 로고    scopus 로고
    • Can we prevent immunogenicity of human protein drugs
    • Scott, D. W., De Groot, A. S. (2010) Can we prevent immunogenicity of human protein drugs? Ann. Rheum. Dis. 69 (Suppl. 1), i72-i76.
    • (2010) Ann. Rheum. Dis , vol.69 , Issue.SUPPL. 1
    • Scott, D.W.1    de Groot, A.S.2
  • 32
    • 84861149390 scopus 로고    scopus 로고
    • B-cell gene therapy for tolerance induction: Host but not donor B-cell derived IL-10 is necessary for tolerance
    • Su, Y, Zhang, A. H., Noben-Trauth, N., Scott, D. W. (2011) B-cell gene therapy for tolerance induction: host but not donor B-cell derived IL-10 is necessary for tolerance. Front. Microbiol. 2, 154.
    • (2011) Front. Microbiol , vol.2 , pp. 154
    • Su, Y.1    Zhang, A.H.2    Noben-Trauth, N.3    Scott, D.W.4
  • 33
    • 80051787580 scopus 로고    scopus 로고
    • B cells "transduced" with TAT-fusion proteins can induce tolerance and protect mice from diabetes and EAE
    • Su, Y, Zhang, A. H., Li, X., Owusu-Boaitey, N., Skupsky, J., Scott, D. W. (2011) B cells "transduced" with TAT-fusion proteins can induce tolerance and protect mice from diabetes and EAE. Clin. Immunol. 140, 260-267.
    • (2011) Clin. Immunol , vol.140 , pp. 260-267
    • Su, Y.1    Zhang, A.H.2    Li, X.3    Owusu-Boaitey, N.4    Skupsky, J.5    Scott, D.W.6
  • 34
    • 49049122300 scopus 로고    scopus 로고
    • B cells induce tolerance by presenting endogenous peptide-IgG on MHC class II molecules via an IFN-7-inducible lysosomal thiol reductase-dependent pathway
    • Su, Y, Carey, G., Maric, M., Scott, D. W. (2008) B cells induce tolerance by presenting endogenous peptide-IgG on MHC class II molecules via an IFN-7-inducible lysosomal thiol reductase-dependent pathway. J. Immunol. 181, 1153-1160.
    • (2008) J. Immunol , vol.181 , pp. 1153-1160
    • Su, Y.1    Carey, G.2    Maric, M.3    Scott, D.W.4
  • 35
    • 23244454645 scopus 로고    scopus 로고
    • Mechanisms of gene therapy for tolerance: B7 signaling is required for peptide-IgG gene-transferred tolerance induction
    • Litzinger, M. T., Su, Y, Lei, T. C, Soukhareva, N., Scott, D. W. (2005) Mechanisms of gene therapy for tolerance: B7 signaling is required for peptide-IgG gene-transferred tolerance induction. J. Immunol. 175, 780-787.
    • (2005) J. Immunol , vol.175 , pp. 780-787
    • Litzinger, M.T.1    Su, Y.2    Lei, T.C.3    Soukhareva, N.4    Scott, D.W.5
  • 36
    • 26944475538 scopus 로고    scopus 로고
    • Tolerance induction via a B-cell delivered gene therapy-based protocol: Optimization and role of the Ig scaffold
    • Lei, T. C, Su, Y, Scott, D. W. (2005) Tolerance induction via a B-cell delivered gene therapy-based protocol: optimization and role of the Ig scaffold. Cell. Immunol. 235, 12-20.
    • (2005) Cell. Immunol , vol.235 , pp. 12-20
    • Lei, T.C.1    Su, Y.2    Scott, D.W.3
  • 37
    • 0033587771 scopus 로고    scopus 로고
    • Induction of hyporesponsiveness to intact foreign protein via retroviral-mediated gene expression: The IgG scaffold is important for induction and maintenance of immune hyporesponsiveness
    • Kang, Y, Melo, M., Deng, E., Tisch, R, El-Amine, M., Scott, D. W. (1999) Induction of hyporesponsiveness to intact foreign protein via retroviral-mediated gene expression: the IgG scaffold is important for induction and maintenance of immune hyporesponsiveness. Proc. Natl. Acad. Sci. USA 96, 8609-8614.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 8609-8614
    • Kang, Y.1    Melo, M.2    Deng, E.3    Tisch, R.4    El-Amine, M.5    Scott, D.W.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.