Upregulated MicroRNA-92b Regulates the Differentiation and Proliferation of EpCAM-Positive Fetal Liver Cells by Targeting C/EBPß

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Qian, Nian Song ^a,b   Liu, Wei Hui ^c   Lv, Wen Ping ^a,b   Xiang, Xin ^a,b   Su, Ming ^a,b   Raut, Vikram ^d   Chen, Yong Liang ^a,b   Dong, Jia Hong ^a  

^a CHINESE PLA GENERAL HOSPITAL   (China)

^b Hainan Branch of PLA General Hospital   (China)

^c CHENGDU MILITARY GENERAL HOSPITAL   (China)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN BETA; EPITHELIAL CELL ADHESION MOLECULE; MICRORNA; MICRORNA 92B; UNCLASSIFIED DRUG;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; C EBP BETA GENE; CELL CYCLE ARREST; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; FEMALE; FETUS; GAIN OF FUNCTION MUTATION; GENE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CARCINOGENESIS; LIVER CELL; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; PROTEIN TARGETING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

ANIMALS; ANTIGENS, NEOPLASM; CARCINOMA, HEPATOCELLULAR; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELL ADHESION MOLECULES; CELL PROLIFERATION; CELLS, CULTURED; FETUS; GENE EXPRESSION PROFILING; HEPATOCYTES; HUMANS; LIVER NEOPLASMS; MALE; MICRORNAS; NEOPLASTIC STEM CELLS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RATS; RATS, INBRED F344; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UP-REGULATION;

EID: 84880966013     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0068004     Document Type: Article

References (50)

1. Reya T, Morrison SJ, Clarke MF, Weissman IL, (2001) Stem cells, cancer, and cancer stem cells. Nature 414: 105-111.
2. Chiba T, Kita K, Zheng YW, Yokosuka O, Saisho H, et al. (2006) Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties. Hepatology 44: 240-251.
3. Yang ZF, Ho DW, Ng MN, Lau CK, Yu WC, et al. (2008) Significance of CD90+ cancer stem cells in human liver cancer. Cancer Cell 13: 153-166.
4. Ma S, Chan KW, Hu L, Lee TK, Wo JY, et al. (2007) Identification and characterization of tumorigenic liver cancer stem/progenitor cells. Gastroenterology 132: 2542-2556.
5. Yamashita T, Ji J, Budhu A, Forgues M, Yang W, et al. (2009) EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology 136: 1012-1024.
6. Chen QR, Xiang J, Liao B, Liu QB, Che LH, et al. (2007) [Evolutive characters of oval cells in experimental hepatocarcinogenesis]. Ai Zheng 26: 719-723.
7. Terris B, Cavard C, Perret C, (2010) EpCAM, a new marker for cancer stem cells in hepatocellular carcinoma. J Hepatol 52: 280-281.
8. Bartel DP, (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297.
9. Gramantieri L, Fornari F, Callegari E, Sabbioni S, Lanza G, et al. (2008) MicroRNA involvement in hepatocellular carcinoma. J Cell Mol Med 12: 2189-2204.
10. Lim IK, (2003) Spectrum of molecular changes during hepatocarcinogenesis induced by DEN and other chemicals in Fisher 344 male rats. Mech Ageing Dev 124: 697-708.
11. Liu WH, Tao KS, You N, Liu ZC, Zhang HT, et al. (2011) Differences in the properties and mirna expression profiles between side populations from hepatic cancer cells and normal liver cells. PLoS One 6: e23311.
12. Chen HF, Chuang CY, Lee WC, Huang HP, Wu HC, et al. (2011) Surface marker epithelial cell adhesion molecule and E-cadherin facilitate the identification and selection of induced pluripotent stem cells. Stem Cell Rev 7: 722-735.
13. Liu WH, Wang X, You N, Tao KS, Wang T, et al. (2012) Efficient enrichment of hepatic cancer stem-like cells from a primary rat HCC model via a density gradient centrifugation-centered method. PLoS One 7: e35720.
14. Hui AB, Shi W, Boutros PC, Miller N, Pintilie M, et al. (2009) Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues. Lab Invest 89: 597-606.
15. Betel D, Wilson M, Gabow A, Marks DS, Sander C, (2008) The microRNA.org resource: targets and expression. Nucleic Acids Res 36: D149-153.
16. Betel D, Koppal A, Agius P, Sander C, Leslie C, (2010) Comprehensive modeling of microRNA targets predicts functional non-conserved and non-canonical sites. Genome Biol 11: R90.
17. Cai J, Zhao Y, Liu Y, Ye F, Song Z, et al. (2007) Directed differentiation of human embryonic stem cells into functional hepatic cells. Hepatology 45: 1229-1239.
18. Soto-Gutierrez A, Navarro-Alvarez N, Zhao D, Rivas-Carrillo JD, Lebkowski J, et al. (2007) Differentiation of mouse embryonic stem cells to hepatocyte-like cells by co-culture with human liver nonparenchymal cell lines. Nat Protoc 2: 347-356.
19. Qian NS, Xu XP, Chen Y, Dou KF, Wang YY, et al. (2010) Protective effect of cyclosporin A on brain injury in rats with acute necrotic pancreatitis. Life Sci 87: 64-68.
20. Sun YF, Xu Y, Yang XR, Guo W, Zhang X, et al. (2012) Circulating stem cell-like EpCAM(+) tumor cells indicate poor prognosis of hepatocellular carcinoma after curative resection. Hepatology.
21. Yamashita T, Honda M, Nakamoto Y, Baba M, Nio K, et al. (2012) Discrete nature of EpCAM(+) and CD90(+) cancer stem cells in human hepatocellular carcinoma. Hepatology.
22. Li R, Qian N, Tao K, You N, Wang X, et al. (2010) MicroRNAs involved in neoplastic transformation of liver cancer stem cells. J Exp Clin Cancer Res 29: 169.
23. Alison MR, (2005) Liver stem cells: implications for hepatocarcinogenesis. Stem Cell Rev 1: 253-260.
24. Sell S, (2004) Stem cell origin of cancer and differentiation therapy. Crit Rev Oncol Hematol 51: 1-28.
25. Ladeiro Y, Couchy G, Balabaud C, Bioulac-Sage P, Pelletier L, et al. (2008) MicroRNA profiling in hepatocellular tumors is associated with clinical features and oncogene/tumor suppressor gene mutations. Hepatology 47: 1955-1963.
26. Meng F, Henson R, Wehbe-Janek H, Ghoshal K, Jacob ST, et al. (2007) MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer. Gastroenterology 133: 647-658.
27. Corney DC, Flesken-Nikitin A, Godwin AK, Wang W, Nikitin AY, (2007) MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth. Cancer Res 67: 8433-8438.
28. Sivaramakrishnan V, Devaraj SN, (2010) Morin fosters apoptosis in experimental hepatocellular carcinogenesis model. Chem Biol Interact 183: 284-292.
29. Yu F, Yao H, Zhu P, Zhang X, Pan Q, et al. (2007) let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell 131: 1109-1123.
30. Xia H, Cheung WK, Sze J, Lu G, Jiang S, et al. (2010) miR-200a regulates epithelial-mesenchymal to stem-like transition via ZEB2 and beta-catenin signaling. J Biol Chem 285: 36995-37004.
31. Sell S, Leffert HL, (2008) Liver cancer stem cells. J Clin Oncol 26: 2800-2805.
32. Yin C, Lin Y, Zhang X, Chen YX, Zeng X, et al. (2008) Differentiation therapy of hepatocellular carcinoma in mice with recombinant adenovirus carrying hepatocyte nuclear factor-4alpha gene. Hepatology 48: 1528-1539.
33. McKnight SL, (2001) McBindall - a better name for CCAAT/enhancer binding proteins? Cell 107: 259-261.
34. Sun W, Shen W, Yang S, Hu F, Li H, et al. (2010) miR-223 and miR-142 attenuate hematopoietic cell proliferation, and miR-223 positively regulates miR-142 through LMO2 isoforms and CEBP-beta. Cell Res 20: 1158-1169.
35. Guerzoni C, Bardini M, Mariani SA, Ferrari-Amorotti G, Neviani P, et al. (2006) Inducible activation of CEBPB, a gene negatively regulated by BCR/ABL, inhibits proliferation and promotes differentiation of BCR/ABL-expressing cells. Blood 107: 4080-4089.
36. Westmacott A, Burke ZD, Oliver G, Slack JM, Tosh D, (2006) C/EBPalpha and C/EBPbeta are markers of early liver development. Int J Dev Biol 50: 653-657.
37. Shen CN, Slack JM, Tosh D, (2000) Molecular basis of transdifferentiation of pancreas to liver. Nat Cell Biol 2: 879-887.
38. Kurash JK, Shen CN, Tosh D, (2004) Induction and regulation of acute phase proteins in transdifferentiated hepatocytes. Exp Cell Res 292: 342-358.
39. Burke ZD, Shen CN, Ralphs KL, Tosh D, (2006) Characterization of liver function in transdifferentiated hepatocytes. J Cell Physiol 206: 147-159.
40. Shen CN, Seckl JR, Slack JM, Tosh D, (2003) Glucocorticoids suppress beta-cell development and induce hepatic metaplasia in embryonic pancreas. Biochem J 375: 41-50.
41. Buck M, Chojkier M, (2003) Signal transduction in the liver: C/EBPbeta modulates cell proliferation and survival. Hepatology 37: 731-738.
42. Greenbaum LE, Li W, Cressman DE, Peng Y, Ciliberto G, et al. (1998) CCAAT enhancer- binding protein beta is required for normal hepatocyte proliferation in mice after partial hepatectomy. J Clin Invest 102: 996-1007.
43. Plante BJ, Kannan A, Bagchi MK, Yuan L, Young SL, (2009) Cyclic regulation of transcription factor C/EBP beta in human endometrium. Reprod Biol Endocrinol 7: 15.
44. Sengupta S, Nie J, Wagner RJ, Yang C, Stewart R, et al. (2009) MicroRNA 92b controls the G1/S checkpoint gene p57 in human embryonic stem cells. Stem Cells 27: 1524-1528.
45. Xia H, Ng SS, Jiang S, Cheung WK, Sze J, et al. (2010) miR-200a-mediated downregulation of ZEB2 and CTNNB1 differentially inhibits nasopharyngeal carcinoma cell growth, migration and invasion. Biochem Biophys Res Commun 391: 535-541.
46. Zhong Z, Dong Z, Yang L, Gong Z, (2012) miR-21 induces cell cycle at S phase and modulates cell proliferation by down-regulating hMSH2 in lung cancer. J Cancer Res Clin Oncol 138: 1781-1788.
47. Buechner J, Henriksen JR, Haug BH, Tomte E, Flaegstad T, et al. (2011) Inhibition of mir-21, which is up-regulated during MYCN knockdown-mediated differentiation, does not prevent differentiation of neuroblastoma cells. Differentiation 81: 25-34.
48. Hoang BH, Kubo T, Healey JH, Yang R, Nathan SS, et al. (2004) Dickkopf 3 inhibits invasion and motility of Saos-2 osteosarcoma cells by modulating the Wnt-beta-catenin pathway. Cancer Res 64: 2734-2739.
49. Fong D, Hermann M, Untergasser G, Pirkebner D, Draxl A, et al. (2009) Dkk-3 expression in the tumor endothelium: a novel prognostic marker of pancreatic adenocarcinomas. Cancer Sci 100: 1414-1420.
50. Veeck J, Wild PJ, Fuchs T, Schuffler PJ, Hartmann A, et al. (2009) Prognostic relevance of Wnt-inhibitory factor-1 (WIF1) and Dickkopf-3 (DKK3) promoter methylation in human breast cancer. BMC Cancer 9: 217.