C/EBPα and C/EBPβ are markers of early liver development

International Journal of Developmental Biology

Volumn 50, Issue 7, 2006, Pages 653-657

  Westmacott, Adam ^a   Burke, Zoë D ^a   Oliver, Guillermo ^b   Slack, Jonathan M W ^a   Tosh, David ^a  

^a University of Bath   (United Kingdom)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

fetoprotein (AFP); C EBP; HNF4; Liver development; Pdx1

Indexed keywords

ALPHA FETOPROTEIN; HEPATOCYTE NUCLEAR FACTOR 4; PROTEIN; PROTEIN C EBP BETA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PDX 1; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; CCAAT ENHANCER BINDING PROTEIN;

ANIMAL EMBRYO; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; GENE EXPRESSION; LIVER CELL; LIVER DEVELOPMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; COMPARATIVE STUDY; EMBRYO DEVELOPMENT; GROWTH, DEVELOPMENT AND AGING; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LIVER; METABOLISM; MOUSE STRAIN; ORGANOGENESIS; PRENATAL DEVELOPMENT;

ALPHA-FETOPROTEINS; ANIMALS; BIOLOGICAL MARKERS; CCAAT-ENHANCER-BINDING PROTEINS; EMBRYONIC DEVELOPMENT; HEPATOCYTE NUCLEAR FACTOR 4; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LIVER; MICE; MICE, INBRED STRAINS; ORGANOGENESIS;

EID: 33749642368     PISSN: 02146282     EISSN: None     Source Type: Journal    
DOI: 10.1387/ijdb.062146aw     Document Type: Article

References (34)

1. BIRKENMEIER, E.H., GWYNN, B., HORWARD, S., JERRY, J., GORDON, J.L., LANDSCHULZ, W.H. and McKINGHT, S.L. (1989). Tissue-specific expression, developmental regulation and genetic mapping of the gene encoding CCAAT/enhancer binding protein. Genes and Dev. 3: 1146-1156.
2. BOGUE, C.W., GANEA, G.R., STURM, E. IANUCCI, R. and JACOBS, H.C. (2000). Hex expression suggests a role in the development and function of organs derived from foregut endoderm. Dev. Dyn. 219: 84-89.
3. BOSSARD, P. and ZARET, K.S. (1998). GATA transcription factors as potentiators of gut endoderm differentiation. Development 125: 4909-4917.
4. BOSSARD, P., MCPHERSON, C.E. and ZARET, K.S. (1997). In vivo footprinting with limiting amounts of embryo tissues: A role for C/EBP beta in early hepatic development. Methods - A companion to Methods in Enzymology 11: 180-188.
5. BURKE, Z.D., SHEN, C-N., RALPHS, K and TOSH, D. (2006). Characterization of liver function in transdifferentiated hepatocytes. J. Cell. Physiol. 206: 147-159.
6. BURKE, Z. and OLIVER, G. (2002). Prox1 is an early specific marker for the developing liver and pancreas in the mammalian foregut endoderm. Mech. Dev. 118: 147-155.
7. DARLINGTON, G.J., ROSS, S.E. and MACDOUGALD, O.A., (1998). The role of C/EBP genes in adipocyte differentiation. J. Biol. Chem. 273: 30057-30060.
8. DIEHL, A.M. (1998). Role of CCAAT/Enhancer binding proteins in regulation of liver regenerative growth. J. Biol. Chem. 273: 30843-40846.
9. FRIEDMAN A.D., LANDSCHULZ W.H. and McKNIGHT, S.L. (1989). CCAAT enhancer binding-protein activates the promoter of the serum-albumin gene in cultured hepatoma-cells. Genes Dev. 3: 1314-1322.
10. INOUE, Y., INOUE, J., LAMBERT, G., YIM, S. H. and GONZALEZ, F. J. (2004). Disruption of hepatic C/EBPa results in impaired glucose tolerance and age-dependent hepatosteatosis. J. Biol. Chem. 279: 44740-44748.
11. JOCHHEIM, A., HILLEMANN, T., KANIA, G., SCHARF, J., ATTARAN, M., MANNS, M.P., WOBUS, A. and OTT, S. (2004). Quantitative gene expression profiling reveals a fetal hepatic phenotype of murine ES-derived hepatocytes. Int. J. Dev. Biol. 48: 23-29.
12. JONSSON J, CARLSSON L, EDLUND T and EDLUND H. (1994). Insulin Promoter Factor 1 is required for pancreas development in mice. Nature 371: 606-609.
13. JUNG, J.N., ZHENG, M.H., GOLDFARB, M. and ZARET, K.S. (1999). Initiation of mammalian liver development from endoderm by fibroblast growth factors. Science 284: 1998-2003.
14. KURASH, J.K., SHEN, C-N. and TOSH, D. (2004). Induction and regulation of acute phase proteins in transdifferentiated hepatocytes. Exp Cell Res. 292: 342-358.
15. LE DOUARIN, N.M. (1975). An experimental analysis of liver development. Med. Biol. 53: 427-455.
16. LEE, C.S., FRIEDMAN, J.R., FULMER, J.T. and KAESTNER, K.H. (2005). The initiation of liver development is dependent on Foxa transcription factors. Nature 435: 944-947.
17. LEKSTROM-HIMES, J. and XANTHOPOULOS, K.G. (1998). Biological activity of the CCAAT/enhancer binding protein family of transcription factors. J. Biol. Chem. 273: 28545-28548.
18. LIU S, CRONIGER C, REN JM, POLI V, HANSON RW and FRIEDMAN JE. (1998). Targeted disruption of C/EBP beta gene results in hypoglycaemia and impaired glucagon-stimulated glucose production. Diabetes 47: A295-A295 Suppl. 1.
19. LYONS, S.E., SHUE, B.C., LEI, L., OATES, A.C., ZON, L.I. and LIU, P.P. (2001). Molecular cloning, genetic mapping and expression analysis of four zebrafish c/ebp genes. Gene 281: 43-51.
20. ROSSI, J.M., DUNN, N.R., HOGAN, B.L.M. and ZARET, K.S. (2001). Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. Genes Dev 15: 1998-2009.
21. RØRTH, P. and MONTELL, D.J. (1992). Drosophila C/EBP: a tissue-specific DNA-binding protein required for embryonic development. Genes Dev. 6: 2299-2311.
22. SCREPANTI I, ROMANI L, MUSIANI P, MODESTI A, FATTORI E, LAZZARO D, SELLITTO C, SCARPA S, BELLAVIA D, LATTANZIO G, BISTONI, F, FRATI, L., CORTESE, R., GULINO, A., CILIBERTO, G., COSTANTINI, F. and POLI, V. (1995). Lymphoproliferative disorder and imbalanced T-helper response in C/EBP-beta-deficient mice. EMBO J. 14: 1932-1941.
23. SHEN, C-N, SLACK, J.M.W. and TOSH, D. (2000). Molecular basis of transdifferentiation of pancreas to liver. Nature Cell Biology 2: 879-887.
24. SHEN, C-N., SECKL, J.R., SLACK, J.M.W. and TOSH, D. (2003). Glucocorticoids suppress beta cell development and induce hepatic metaplasia in embryonic pancreas. Biochem. J. 375: 41-50.
25. SHIOJIRI, N., TAKESHITA, K., YAMASAKI, H. and IWATA, T. (2004). Suppression of C/EBPα expression in biliary cell differentiation from hepatoblasts during mouse liver development. J. Hepatol. 41: 790-798.
26. SLACK, J.M.W. and TOSH, D. (2001). Transdifferentiation and metaplasia - switching of cell types. Curr. Opin. in Genet. Dev. 11: 581-586.
27. THOMAS, P.O., BROWN, A and BEDDINGTON, R.S.P. (1998). Hex: a homeobox gene revealing pre-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors. Development 125: 85-94.
28. TOSH, D., SHEN, C-N and SLACK, J.M.W. (2002). Differentiated properties of hepatocytes induced from pancreatic cells. Hepatology 36: 534-543.
29. TOSH, D. and SLACK, J.M.W. (2002). How cells change their phenotype. Nature Reviews Molecular Cell Biology. 3: 187-194.
30. UMEK R.M., FRIEDMAN A.D. and McKNIGHT, S.L. (1991). CCAAT-enhancer binding-protein - a component of a differentiation switch. Science 251: 288-292
31. WANG, N.D., FINEGOLD, M.J., BRADLEY, A., OU, C.N., ABDELSAYED, S.V., WILDE, M.D., TAYLOR, L.R., WILSON, D.R. and DARLINGTON, G.J. (1995). Impaired Energy Homeostasis in C/EBP-alpha knockout mice. Science 269: 1108-1112.
32. YANG, J., CRONIGER, C.M., LEKSTROM-HIMES, J., ZHANG, P., FENYUS, F, TENEN, D.G., DARLINGTON, D.J. and HANSON, R.W. (2005). Metabolic response of mice to a postnatal ablation of CCAAT/Enhancer-binding protein a. J. Biol. Chem. 280: 38689-38699.
33. ZHANG, W., YATSKIEVYCH, T.A., BAKER, R.K. and ANIN, P.B. (2004). Regulation of Hex gene expression and initial stages of avian hepatogenesis by Bmp and Fgf signaling. Dev. Biol. 268: 312-326.
34. ZHAO, R. and DUNCAN, S.A. (2005). Embryonic development of the liver. Hepatology 41: 956-967.