Sequential induction of type i and II interferons mediates a long-lasting gene induction in the liver in response to a novel toll-like receptor 9 agonist

Journal of Hepatology

Volumn 58, Issue 4, 2013, Pages 743-749

  Makowska, Zuzanna ^a   Blumer, Tanja ^a   Duong, François H T ^a   La Monica, Nicola ^b   Kandimalla, Ekambar R ^b   Heim, Markus H ^a,c  

^a UNIVERSITY OF BASEL   (Switzerland)

^b HYBRIDON INC   (United States)

^c UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Hepatitis C virus; Interferon; Liver; Oligonucleotide; Toll like receptor 9

Indexed keywords

ALPHA BETA INTERFERON RECEPTOR; ALPHA INTERFERON; CHEMOKINE; GAMMA INTERFERON; IMMUNOMODULATORY OLIGONUCLEOTIDE; IMO 2125; INTERFERON; INTERFERON STIMULATED GENE FACTOR 3; JANUS KINASE; OLIGONUCLEOTIDE; STAT PROTEIN; STAT1 PROTEIN; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANION EXCHANGE; ARTICLE; CHRONIC HEPATITIS; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL ELECTROPHORESIS; GENE EXPRESSION; GENE INDUCTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOCHEMISTRY; INTERFERON INDUCTION; LIMULUS LYSATE TEST; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MICROARRAY ANALYSIS; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; T LYMPHOCYTE; TREATMENT RESPONSE; WESTERN BLOTTING;

ANIMALS; CHEMOKINES; CYTOKINES; IMMUNOLOGIC FACTORS; INTERFERON TYPE I; INTERFERON-GAMMA; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OLIGODEOXYRIBONUCLEOTIDES; RECEPTOR, INTERFERON ALPHA-BETA; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; TOLL-LIKE RECEPTOR 9; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

EID: 84880963055     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2012.11.038     Document Type: Article

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