Exposure to phthalic acid, phthalate diesters and phthalate monoesters from foodstuffs: UK total diet study results

Food Additives and Contaminants - Part A

Volumn 30, Issue 4, 2013, Pages 735-742

  Bradley, Emma L ^a   Burden, Richard A ^b   Bentayeb, Karim ^c   Driffield, Malcolm ^a   Harmer, Nick ^a   Mortimer, David N ^b   Speck, Dennis R ^a   Ticha, Jana ^a   Castle, Laurence ^a  

^a FOOD AND ENVIRONMENT RESEARCH AGENCY   (United Kingdom)

^b FOOD STANDARDS AGENCY   (United Kingdom)

^c UNIVERSITY OF ZARAGOZA   (Spain)

Author keywords

exposure; method validation; phthalate; total diet study

Indexed keywords

CARBOXYLIC ACIDS; CONSUMER PRODUCTS; DICHLOROMETHANE; ESTERS; HEALTH RISKS; NUTRITION;

DI(2-ETHYLHEXYL)PHTHALATE; DI-N-BUTYL PHTHALATE; EXPOSURE; METHOD VALIDATIONS; MONO-(2-ETHYLHEXYL)PHTHALATE; PHTHALATES; QUANTITATIVE DETERMINATIONS; TOTAL DIET STUDIES;

CHEMICAL CONTAMINATION;

ACETONITRILE; CARBOHYDRATE; DICHLOROMETHANE; OIL; PHTHALIC ACID; PHTHALIC ACID 2 ETHYLHEXYL MONOESTER; PHTHALIC ACID BENZYL MONOESTER; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; PHTHALIC ACID BUTYL MONOESTER; PHTHALIC ACID CYCLOHEXYL MONOESTER; PHTHALIC ACID DIBUTYL ESTER; PHTHALIC ACID ESTER; PHTHALIC ACID ISOBUTYL MONOESTER; PHTHALIC ACID ISONONYL MONOESTER; PHTHALIC ACID ISOPROPYL MONOESTER; PHTHALIC ACID OCTYL MONOESTER; PHTHALIC ACID PENTYL MONOESTER; PROTEIN; SUGAR; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ARTICLE; BEVERAGE; BREAD; CANNED FOOD; CHILD; CONCENTRATION (PARAMETERS); DAIRY PRODUCT; EGG; ENVIRONMENTAL EXPOSURE; FAT INTAKE; FOOD CONTAMINATION; FRUIT; GOVERNMENT; HEALTH HAZARD; HUMAN; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; MEAT; METHODOLOGY; NUT; POTATO; POULTRY; PRESCHOOL CHILD; PRIORITY JOURNAL; RISK ASSESSMENT; SCHOOL CHILD; STANDARD; TANDEM MASS SPECTROMETRY; UNITED KINGDOM; VEGETABLE;

ANIMALIA;

EID: 84880957921     PISSN: 19440049     EISSN: 14645122     Source Type: Journal    
DOI: 10.1080/19440049.2013.781684     Document Type: Article

References (41)

1. Albro PW, Chapin RE, Corbett JT, Schroeder J, Phelps JL. 1989. Mono-2-ethylhexyl phthalate, a metabolite of di-(2-ethylhexyl) phthalate, causally linked to testicular atrophy in rats. Toxicol Appl Pharmacol. 100:193-200.
2. Anderson WAC, Barnes KA, Castle L, Damant AP, Scotter MJ. 2002. Determination of isotopically labelled monoesterphthalates in urine by high performance liquid chromatography-mass spectrometry. Analyst. 127:1193-1197.
3. Bradley EL. 2011. FSA PROJECT C01048. Determination of phthalates in foods and establishing methodology to distinguish their source [Internet]; London: Food Standards Agency; [cited 2012 Sep 30]. Available from: http://www.foodbase.org.uk//admintools/reportdocuments/740-1-1258_C01048_phthalates.pdf
4. Bradley EL, Leon I, Mortimer D, Speck DR, Castle L. 2013. Determination of phthalate diesters in foods. Food Addit Contam A. doi: 10.1080/19440049.2013.781683.
5. Calafat AM, Slakman AR, Silva MJ, Herbert AR, Needham LL. 2004. Automated solid phase extraction and quantitative analysis of human milk for 13 phthalate metabolites. J Chromatogr B. 805:49-56.
6. Cao XL. 2010. Phthalate esters in foods: sources, occurrence, and analytical methods. Compr Rev Food Sci Food Saf. 9:21-43.
7. Cavaliere B, Macchione B, Sindona G, Tagarelli A. 2008. Tandem mass spectrometry in food safety assessment: the determination of phthalates in olive oil. J Chromatogr A. 1205:137-143.
8. [COT] Committee on Toxicity. 2011. Committee on toxicity ofchemicals in food. Consumer products and the environment [Internet]. COT statement on dietary exposure to phthalates - data from the total diet study (TDS); London: Food Standards Agency; [cited 2012 Sep 30]. Available from: http://cot.food.gov.uk/pdfs/cotstatementphthalates201104.pdf
9. Ema M, Kurosaka R, Amano H, Ogawa Y. 1995. Developmental toxicity evaluation of mono-n-butyl phthalate in rats. Toxicol Lett. 78:101-106.
10. European Commission. 2011. COMMISSION REGULATION (EU) No 10/2011 of 14 January 2011 on plastic materials and articles intended to come into contact with food. Off J Eur Comm. L 12:1-89.
11. [EFSA] European Food Safety Authority. 2005a. Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the commission related to butylbenzylphthalate (BBP) for use in food contact materials [Internet]. EFSA J. 241:1-14; [cited 2012 Sep 30]. Available from: http://www.efsa.europa.eu/en/scdocs/scdoc/241.htm
12. [EFSA] European Food Safety Authority. 2005b. Opinion of the scientific panel on food additives, flavourings, processing aids and material in contact with food (AFC) on a request from the commission related to di-butylphthalate (DBP) for use in food contact materials [Internet]. EFSA J. 242:1-17; [cited 2012 Sep 30]. Available from: http://www.efsa.europa.eu/en/scdocs/scdoc/242.htm
13. [EFSA] European Food Safety Authority. 2005c. Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the commission related to bis(2-ethylhexyl)phthalate (DEHP) for use in food contact materials [Internet]. EFSA J. 243:1-20; [cited 2012 Sep 30]. Available from: http://www.efsa.europa.eu/en/scdocs/scdoc/243.htm
14. [EFSA] European Food Safety Authority. 2005d. Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the commission related to di-isononylphthalate (DINP) for use in food contact materials [Internet]. EFSA J. 244:1-18; [cited 2012 Sep 30]. Available from: http://www.efsa.europa.eu/en/scdocs/scdoc/244.htm
15. [EFSA] European Food Safety Authority. 2005e. Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request from the commission related to di-isodecylphthalate (DIDP) for use in food contact materials [Internet]. EFSA J. 245:1-14; [cited 2012 Sep 30]. Available from: http://www.efsa.europa.eu/en/scdocs/scdoc/245.htm
16. [EFSA] European Food Safety Authority. 2005f. Opinion of the scientific committee on a request from EFSA related to exposure assessment [Internet]; Parma: EFSA; [cited 2012 Sep 30]. Available from: http://www.efsa.europa.eu/EFSA/efsa_locale-1178620753812_1178620763345.htm
17. Fierens T, Servaes K, Van Holderbeke M, Geerts L, De Henauw S, Sioen I, Vanermen G. 2012. Analysis of phthalates in food products and packaging materials sold on the Belgian market. Food Chem Toxicol. 50:2575-2583.
18. Finch S, Doyle W, Lowe C, Bates CJ, Prentice A, Smithers G, Clarke PC. 1998. National diet and nutrition survey: people aged 65 years and over. Volume 1: report of the diet and nutrition survey. London: HMSO.
19. Godwin A. 2010. Use of phthalates and other plasticisers [Internet]; [cited 2012 Sep 30]. Available from: http://www.cpsc.gov/about/cpsia/chap/godwin.pdf
20. Gregory JR, Collins DL, Davies PSW, Hughes JM, Clarke PC. 1995. National diet and nutrition survey: children aged 1 1/2 to 4 1/2 years. Volume 1: report of the diet and nutrition survey. London: HMSO.
21. Heindel JJ, Powell CJ. 1992. Phthalate ester effects on rat sertoli cell function in vitro: effects of phthalate side chain and age of animal. Toxicol Appl Pharm. 115:116-123.
22. Henderson L, Gregory J, Swan G. 2002. National Diet and Nutrition Survey: adults Aged 19 to 64 years. Volume 1: types and quantities of foods consumed. London: HMSO.
23. Holm A, Solbu K, Molander P, Lundanes E, Greibrokk T. 2004. Sensitive biomonitoring of phthalate metabolites in human urine using packed capillary column switching liquid chromatography coupled to electrospray ionization ion-trap mass spectrometry. Anal Bioanal Chem. 378:1762-1768.
24. Hubert WW, Grasl-Kraupp B, Schulte-Hermann R. 1996. Hepatocarcinogenic potential of di(2-ethylhexyl)phthalate in rodents and its implications on human risk. Crit Rev Toxicol. 26:365-481.
25. Koch HM, Gonzalez-Reche LM, Angerer J. 2003. On-line cleanup by multidimensional LC-ESI-MS/MS for high throughput quantification of primary and secondary phthalate metabolites in human urine. J Chromatogr B. 784: 169-182.
26. Latini G. 2005. Monitoring phthalate exposure in humans. Clinica Chimica Acta. 361:20-29.
27. Latini G, Del Vecchio A, Massaro M, Verrotti A, De Felice C. 2006. Phthalate exposure and male infertility. Toxicol. 226:90-98.
28. Main KM, Mortensen G-K, Kaleva MM, Kirsten A, Boisen KA, Damgaard IN, Chellakooty M, Schmidt IM, Suomi A-M, Virtanen HE, et al. 2006. Human breast milk contamination with phthalates and alterations of endogenous reproductive hormones in infants three months of age. Environ Health Persp. 114:270-276.
29. Mortensen GK, Main KM, Andersson AM, Leffers H, Skakkebwk NE. 2005. Determination of phthalate monoesters in human milk, consumer milk, and infant formula by tandem mass spectrometry (LC-MS-MS). Anal Bioanal Chem. 382:1084-1092.
30. Peattie ME, Buss DH, Lindsay DG, Smart GQ. 1983. Reorganisation of the British total diet study for monitoring food constituents from 1981. Food Chem Toxicol. 21: 503-507.
31. Pedersen GA, Jensena LK, Fankhauser A, Biedermann S, Petersen JH, Fabech B. 2008. Migration of epoxidised soybean oil (ESBO) and phthalates from twist closures into food and enforcement of the overall migration limit. Food Addit Contam A. 25:503-510.
32. Petersen JH, Breindahl T. 2000. Plasticizers in total diet samples, baby food and infant formulae. Food Addit Contam. 17: 133-141.
33. Petrovic M, Eljarrat E, Lopez de Alda MJ, Barceló D. 2004. Endocrine disrupting compounds and other emerging contaminants in the environment: a survey on new monitoring strategies and occurrence data. Anal Bioanal Chem. 378:549-562.
34. Sannino A. 2009. Survey of phthalate levels in Italian oily foods contained in glass jars with PVC gaskets. Food Addit Contam B. 2:166-170.
35. Silva MJ, Samandar E, Preau JL Jr, Reidy JA, Needham LL, Calafat AM. 2007. Quantification of 22 phthalate metabolites in human urine. J Chromatogr B. 860:106-112.
36. Silva MJ, Slakman AR, Reidy JA, Preau JL, Herbert AR, Samandar E, Needham LL, Calafat AM. 2004. Analysis of human urine for fifteen phthalate metabolites using automated solid-phase extraction. J Chromatogr B. 805:161-167.
37. Sioen I, Fierens T, Van Holderbeke M, Geerts L, Bellemans M, De Maeyer M, Servaes K, Vanermen G, Boon PE, De Henauw S. 2012. Phthalates dietary exposure and food sources for Belgian preschool children and adults. Environ Int. 48:102-108.
38. Sorensen LK. 2006. Determination of phthalates in milk and milk products by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 20:1135-1143.
39. Vikelsøe J, Thomsen M, Johansen E, Carlsen L. 1999. Phthaates and nonylphenols in soil [Internet]. NERI Technical Report No. 268; Denmark: Ministry of Environment and Energy; [cited 2012 Sep 30]. Available from: http://www2.dmu.dk/1_viden/2_publikationer/3_fagrapporter/rapporter/fr268.pdf
40. [WHO] World Health Organisation. 2000. Human exposure assessment. IPCS environmental health criteria 214 [Internet]. Geneva: World Health Organization; [cited 2012 Sep 30]. Available from: http://www.inchem.org/documents/ehc/ehc/ehc214.htm
41. [WHO] World Health Organisation. 2003. Diethyl phthalate [Internet]. Concise International Chemical Assessment. Document 52; Geneva: World Health Organization; [cited 2012 Sep 30]. Available from: http://www.who.int/ipcs/publications/cicad/en/cicad52.pdf