Mechanistic analysis of trehalose synthase from Mycobacterium smegmatis

Journal of Biological Chemistry

Volumn 286, Issue 41, 2011, Pages 35601-35609

  Zhang, Ran ^a   Pan, Yuan T ^b   He, Shouming ^a   Lam, Michael ^a   Brayer, Gary D ^a   Elbein, Alan D ^b   Withers, Stephen G ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYTIC NUCLEOPHILES; CONFORMATIONAL CHANGE; CONTINUOUS ASSAY; DEUTERIUM KINETIC ISOTOPE EFFECT; DISPLACEMENT MECHANISMS; ENZYME ACTIVE SITES; GLYCOSIDE HYDROLASES; GLYCOSYL-ENZYME INTERMEDIATE; HYDROLYTIC CLEAVAGE; INTRAMOLECULAR PROCESS; ISOMERASES; ISOMERIZATION REACTION; LC-MS/MS; LEAVING GROUPS; MECHANISTIC ANALYSIS; MYCOBACTERIUM SMEGMATIS; PROTEASE DIGESTION; REVERSIBLE INTERCONVERSION; SYNTHASES;

BACTERIA; CARBOHYDRATES; CATALYSIS; DEUTERIUM; ENZYMES; FLUORINE COMPOUNDS; GLUCOSE; ISOMERIZATION; MALTOSE;

REACTION INTERMEDIATES;

5 FLUOROGLYCOSYL FLUORIDE; ALPHA GLUCOSIDASE; ARYL ALPHA GLUCOSIDASE; DEUTERIUM; FLUORIDE; GLUCOSE; GLYCOSIDASE; MALTOSE; NUCLEOPHILE; TREHALOSE; TREHALOSE SYNTHASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SUBSTRATE; ISOMERIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MYCOBACTERIUM SMEGMATIS; NONHUMAN; PH; PRIORITY JOURNAL;

BACTERIAL PROTEINS; DEUTERIUM EXCHANGE MEASUREMENT; GLUCOSYLTRANSFERASES; GLYCOSIDE HYDROLASES; KINETICS; MYCOBACTERIUM SMEGMATIS; SUBSTRATE SPECIFICITY;

MYCOBACTERIUM SMEGMATIS;

EID: 80053907355     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.280362     Document Type: Article

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