메뉴 건너뛰기




Volumn 31, Issue 7, 2013, Pages 480-490

Hypervascular hepatocellular carcinomas showing hyperintensity on hepatobiliary phase of gadoxetic acid-enhanced magnetic resonance imaging: A possible subtype with mature hepatocyte nature

Author keywords

Gadoxetic acid; HCC; OATP8; Paradoxical uptake; Prognosis

Indexed keywords

ALPHA FETOPROTEIN; BETA CATENIN; CELL PROTEIN; CYTOKERATIN 19; EPITHELIAL CELL ADHESION MOLECULE; GADOXETIC ACID; GLYPICAN 3; HEPATIC STEM CELL MARKER; HEPATOCYTE PARAFFIN 1; NERVE CELL ADHESION MOLECULE; ORGANIC ANION TRANSPORTER POLYPEPTIDE; POLYPEPTIDE; PROTEIN INDUCED BY VITAMIN K ABSENCE OR ANTAGONIST II; TUMOR MARKER; UNCLASSIFIED DRUG;

EID: 84880923249     PISSN: 18671071     EISSN: 1867108X     Source Type: Journal    
DOI: 10.1007/s11604-013-0224-6     Document Type: Article
Times cited : (22)

References (43)
  • 1
    • 15844425224 scopus 로고    scopus 로고
    • Liver tumors: Comparison of MR imaging with Gd-EOB-DTPA and Gd-DTPA
    • 8657946 1:STN:280:DyaK283lslWnsw%3D%3D
    • Vogl T, Kümmel S, Hammerstingl R, Schellenbeck M, Schumacher G, Balzer T, et al. Liver tumors: comparison of MR imaging with Gd-EOB-DTPA and Gd-DTPA. Radiology. 1996;200(1):59-67.
    • (1996) Radiology , vol.200 , Issue.1 , pp. 59-67
    • Vogl, T.1    Kümmel, S.2    Hammerstingl, R.3    Schellenbeck, M.4    Schumacher, G.5    Balzer, T.6
  • 2
    • 25144495562 scopus 로고    scopus 로고
    • Efficacy and safety of MR imaging with liver-specific contrast agent: U.S. multicenter phase III study
    • 16126918 10.1148/radiol.2371031842
    • Bluemke D, Sahani D, Amendola M, Balzer T, Breuer J, Brown J, et al. Efficacy and safety of MR imaging with liver-specific contrast agent: U.S. multicenter phase III study. Radiology. 2005;237(1):89-98.
    • (2005) Radiology , vol.237 , Issue.1 , pp. 89-98
    • Bluemke, D.1    Sahani, D.2    Amendola, M.3    Balzer, T.4    Breuer, J.5    Brown, J.6
  • 3
    • 1842450733 scopus 로고    scopus 로고
    • Hepatobiliary contrast agents for contrast-enhanced MRI of the liver: Properties, clinical development and applications
    • 14986050 10.1007/s00330-004-2236-1
    • Reimer P, Schneider G, Schima W. Hepatobiliary contrast agents for contrast-enhanced MRI of the liver: properties, clinical development and applications. Eur Radiol. 2004;14(4):559-78.
    • (2004) Eur Radiol , vol.14 , Issue.4 , pp. 559-578
    • Reimer, P.1    Schneider, G.2    Schima, W.3
  • 4
    • 0026533551 scopus 로고
    • Preclinical evaluation of Gd-EOB-DTPA as a contrast agent in MR imaging of the hepatobiliary system
    • 1549695 1:CAS:528:DyaK38XitlSqs78%3D
    • Schuhmann-Giampieri G, Schmitt-Willich H, Press W, Negishi C, Weinmann H, Speck U. Preclinical evaluation of Gd-EOB-DTPA as a contrast agent in MR imaging of the hepatobiliary system. Radiology. 1992;183(1):59-64.
    • (1992) Radiology , vol.183 , Issue.1 , pp. 59-64
    • Schuhmann-Giampieri, G.1    Schmitt-Willich, H.2    Press, W.3    Negishi, C.4    Weinmann, H.5    Speck, U.6
  • 5
    • 0029986898 scopus 로고    scopus 로고
    • Phase II clinical evaluation of Gd-EOB-DTPA: Dose, safety aspects, and pulse sequence
    • 8633143 1:STN:280:DyaK283gtFyqug%3D%3D
    • Reimer P, Rummeny E, Shamsi K, Balzer T, Daldrup H, Tombach B, et al. Phase II clinical evaluation of Gd-EOB-DTPA: dose, safety aspects, and pulse sequence. Radiology. 1996;199(1):177-83.
    • (1996) Radiology , vol.199 , Issue.1 , pp. 177-183
    • Reimer, P.1    Rummeny, E.2    Shamsi, K.3    Balzer, T.4    Daldrup, H.5    Tombach, B.6
  • 6
    • 32944464999 scopus 로고    scopus 로고
    • Gd-EOB-DTPA enhanced MRI for hepatocellular carcinoma: Quantitative evaluation of tumor enhancement in hepatobiliary phase
    • 16127248 10.2463/mrms.4.1
    • Saito K, Kotake F, Ito N, Ozuki T, Mikami R, Abe K, et al. Gd-EOB-DTPA enhanced MRI for hepatocellular carcinoma: quantitative evaluation of tumor enhancement in hepatobiliary phase. Magn Reson Med Sci. 2005;4(1):1-9.
    • (2005) Magn Reson Med Sci. , vol.4 , Issue.1 , pp. 1-9
    • Saito, K.1    Kotake, F.2    Ito, N.3    Ozuki, T.4    Mikami, R.5    Abe, K.6
  • 7
    • 12344296444 scopus 로고    scopus 로고
    • Enhancement of focal liver lesions at gadoxetic acid-enhanced MR imaging: Correlation with histopathologic findings and spiral CT - Initial observations
    • 15591431 10.1148/radiol.2342040278
    • Huppertz A, Haraida S, Kraus A, Zech C, Scheidler J, Breuer J, et al. Enhancement of focal liver lesions at gadoxetic acid-enhanced MR imaging: correlation with histopathologic findings and spiral CT - initial observations. Radiology. 2005;234(2):468-78.
    • (2005) Radiology , vol.234 , Issue.2 , pp. 468-478
    • Huppertz, A.1    Haraida, S.2    Kraus, A.3    Zech, C.4    Scheidler, J.5    Breuer, J.6
  • 8
    • 77956112733 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Signal intensity at gadoxetic acid-enhanced MR Imaging - Correlation with molecular transporters and histopathologic features
    • 20663969 10.1148/radiol.10092214
    • Kitao A, Zen Y, Matsui O, Gabata T, Kobayashi S, Koda W, Kozaka K, Yoneda N, et al. Hepatocellular carcinoma: signal intensity at gadoxetic acid-enhanced MR Imaging - correlation with molecular transporters and histopathologic features. Radiology. 2010;256(3):817-26.
    • (2010) Radiology , vol.256 , Issue.3 , pp. 817-826
    • Kitao, A.1    Zen, Y.2    Matsui, O.3    Gabata, T.4    Kobayashi, S.5    Koda, W.6    Kozaka, K.7    Yoneda, N.8
  • 10
    • 1642491778 scopus 로고    scopus 로고
    • The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma
    • 14739090 10.1016/j.jhep.2003.10.008 1:CAS:528:DC%2BD2cXltVCisw%3D%3D
    • Vavricka SR, Jung D, Fried M, Grutzner U, Meier PJ, Kullak-Ublick GA. The human organic anion transporting polypeptide 8 (SLCO1B3) gene is transcriptionally repressed by hepatocyte nuclear factor 3beta in hepatocellular carcinoma. J Hepatol. 2004;40(2):212-8.
    • (2004) J Hepatol , vol.40 , Issue.2 , pp. 212-218
    • Vavricka, S.R.1    Jung, D.2    Fried, M.3    Grutzner, U.4    Meier, P.J.5    Kullak-Ublick, G.A.6
  • 11
    • 0035813209 scopus 로고    scopus 로고
    • Characterization of the human OATP-C (SLC21A6) gene promoter and regulation of liver-specific OATP genes by hepatocyte nuclear factor 1 alpha
    • 11483603 10.1074/jbc.M103988200 1:CAS:528:DC%2BD3MXns1elur0%3D
    • Jung D, Hagenbuch B, Gresh L, Pontoglio M, Meier PJ, Kullak-Ublick GA. Characterization of the human OATP-C (SLC21A6) gene promoter and regulation of liver-specific OATP genes by hepatocyte nuclear factor 1 alpha. J Biol Chem. 2001;276(40):37206-14.
    • (2001) J Biol Chem , vol.276 , Issue.40 , pp. 37206-37214
    • Jung, D.1    Hagenbuch, B.2    Gresh, L.3    Pontoglio, M.4    Meier, P.J.5    Kullak-Ublick, G.A.6
  • 12
    • 77952722303 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: Hepatocyte-selective enhancement at gadoxetic acid-enhanced MR imaging - Correlation with expression of sinusoidal and canalicular transporters and bile accumulation
    • 20501720 10.1148/radiol.10091557
    • Tsuboyama T, Onishi H, Kim T, Akita H, Hori M, Tatsumi M, et al. Hepatocellular carcinoma: hepatocyte-selective enhancement at gadoxetic acid-enhanced MR imaging - correlation with expression of sinusoidal and canalicular transporters and bile accumulation. Radiology. 2010;255(3):824-33.
    • (2010) Radiology , vol.255 , Issue.3 , pp. 824-833
    • Tsuboyama, T.1    Onishi, H.2    Kim, T.3    Akita, H.4    Hori, M.5    Tatsumi, M.6
  • 13
    • 84870005723 scopus 로고    scopus 로고
    • Hypervascular hepatocellular carcinoma: Correlation between biologic features and signal intensity on gadoxetic acid-enhanced MR images
    • 23175543 10.1148/radiol.12120226
    • Kitao A, Matsui O, Yoneda N, Kozaka K, Kobayashi S, Koda W, et al. Hypervascular hepatocellular carcinoma: correlation between biologic features and signal intensity on gadoxetic acid-enhanced MR images. Radiology. 2012;265(3):780-9.
    • (2012) Radiology , vol.265 , Issue.3 , pp. 780-789
    • Kitao, A.1    Matsui, O.2    Yoneda, N.3    Kozaka, K.4    Kobayashi, S.5    Koda, W.6
  • 14
    • 7044226268 scopus 로고    scopus 로고
    • Issues in screening and surveillance for hepatocellular carcinoma
    • 15508072 10.1053/j.gastro.2004.09.022
    • Di Bisceglie AM. Issues in screening and surveillance for hepatocellular carcinoma. Gastroenterology. 2004;127(5 Suppl 1):S104-7.
    • (2004) Gastroenterology , vol.127 , Issue.5 SUPPL. 1
    • Di Bisceglie, A.M.1
  • 15
    • 0027939329 scopus 로고
    • Clinical significance of abnormal prothrombin (DCP) in relation to postoperative survival and prognosis in patients with hepatocellular carcinoma
    • 7526679 1:STN:280:DyaK2M%2Fmslynsw%3D%3D
    • Inoue S, Nakao A, Harada A, Nonami T, Takagi H. Clinical significance of abnormal prothrombin (DCP) in relation to postoperative survival and prognosis in patients with hepatocellular carcinoma. Am J Gastroenterol. 1994;89(12):2222-6.
    • (1994) Am J Gastroenterol , vol.89 , Issue.12 , pp. 2222-2226
    • Inoue, S.1    Nakao, A.2    Harada, A.3    Nonami, T.4    Takagi, H.5
  • 16
    • 0036068640 scopus 로고    scopus 로고
    • Clinicopathologic features of patients with hepatocellular carcinoma seropositive for alpha-fetoprotein-L3 and seronegative for des-gamma-carboxy prothrombin in comparison with those seropositive for des-gamma-carboxy prothrombin alone
    • 12121507 10.1046/j.1440-1746.2002.02806.x 1:CAS:528:DC%2BD38XntlSqtrc%3D
    • Okuda H, Nakanishi T, Takatsu K, Saito A, Hayashi N, Yamamoto M, et al. Clinicopathologic features of patients with hepatocellular carcinoma seropositive for alpha-fetoprotein-L3 and seronegative for des-gamma-carboxy prothrombin in comparison with those seropositive for des-gamma-carboxy prothrombin alone. J Gastroenterol Hepatol. 2002;17(7):772-8.
    • (2002) J Gastroenterol Hepatol , vol.17 , Issue.7 , pp. 772-778
    • Okuda, H.1    Nakanishi, T.2    Takatsu, K.3    Saito, A.4    Hayashi, N.5    Yamamoto, M.6
  • 17
    • 37549061023 scopus 로고    scopus 로고
    • Lens culinaris agglutinin-reactive alpha-fetoprotein and protein induced by vitamin K absence II are potential indicators of a poor prognosis: A histopathological study of surgically resected hepatocellular carcinoma
    • 18085353 10.1007/s00535-007-2117-x 1:CAS:528:DC%2BD2sXhsVelsbzN
    • Miyaaki H, Nakashima O, Kurogi M, Eguchi K, Kojiro M. Lens culinaris agglutinin-reactive alpha-fetoprotein and protein induced by vitamin K absence II are potential indicators of a poor prognosis: a histopathological study of surgically resected hepatocellular carcinoma. J Gastroenterol. 2007;42(12):962-8.
    • (2007) J Gastroenterol , vol.42 , Issue.12 , pp. 962-968
    • Miyaaki, H.1    Nakashima, O.2    Kurogi, M.3    Eguchi, K.4    Kojiro, M.5
  • 18
    • 33645742425 scopus 로고    scopus 로고
    • A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells
    • 16532004 10.1038/nm1377 1:CAS:528:DC%2BD28XjtFKjtLg%3D
    • Lee JS, Heo J, Libbrecht L, Chu IS, Kaposi-Novak P, Calvisi DF, et al. A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells. Nat Med. 2006;12(4):410-6.
    • (2006) Nat Med , vol.12 , Issue.4 , pp. 410-416
    • Lee, J.S.1    Heo, J.2    Libbrecht, L.3    Chu, I.S.4    Kaposi-Novak, P.5    Calvisi, D.F.6
  • 19
    • 33749182067 scopus 로고    scopus 로고
    • The phenotypes of pluripotent human hepatic progenitors
    • 16627685 10.1634/stemcells.2006-0036 1:CAS:528:DC%2BD28XhtFKiurbJ
    • Schmelzer E, Wauthier E, Reid LM. The phenotypes of pluripotent human hepatic progenitors. Stem Cells. 2006;24(8):1852-8.
    • (2006) Stem Cells. , vol.24 , Issue.8 , pp. 1852-1858
    • Schmelzer, E.1    Wauthier, E.2    Reid, L.M.3
  • 20
    • 34547803161 scopus 로고    scopus 로고
    • Human hepatic stem cells from fetal and postnatal donors
    • 17664288 10.1084/jem.20061603 1:CAS:528:DC%2BD2sXptVyjsbs%3D
    • Schmelzer E, Zhang L, Bruce A, Wauthier E, Ludlow J, Yao HL, et al. Human hepatic stem cells from fetal and postnatal donors. J Exp Med. 2007;204(8):1973-87.
    • (2007) J Exp Med , vol.204 , Issue.8 , pp. 1973-1987
    • Schmelzer, E.1    Zhang, L.2    Bruce, A.3    Wauthier, E.4    Ludlow, J.5    Yao, H.L.6
  • 21
    • 33745601104 scopus 로고    scopus 로고
    • Isolation of multipotent progenitor cells from human fetal liver capable of differentiating into liver and mesenchymal lineages
    • 16782807 10.1073/pnas.0603824103 1:CAS:528:DC%2BD28XmvVajtLY%3D
    • Dan YY, Riehle KJ, Lazaro C, Teoh N, Haque J, Campbell JS, et al. Isolation of multipotent progenitor cells from human fetal liver capable of differentiating into liver and mesenchymal lineages. Proc Natl Acad Sci U S A. 2006;103(26):9912-7.
    • (2006) Proc Natl Acad Sci U S A. , vol.103 , Issue.26 , pp. 9912-9917
    • Dan, Y.Y.1    Riehle, K.J.2    Lazaro, C.3    Teoh, N.4    Haque, J.5    Campbell, J.S.6
  • 22
    • 33947409989 scopus 로고    scopus 로고
    • Identification of hepatocytic and bile ductular cell lineages and candidate stem cells in bipolar ductular reactions in cirrhotic human liver
    • 17326146 10.1002/hep.21557
    • Zhou H, Rogler LE, Teperman L, Morgan G, Rogler CE. Identification of hepatocytic and bile ductular cell lineages and candidate stem cells in bipolar ductular reactions in cirrhotic human liver. Hepatology. 2007;45(3):716-24.
    • (2007) Hepatology , vol.45 , Issue.3 , pp. 716-724
    • Zhou, H.1    Rogler, L.E.2    Teperman, L.3    Morgan, G.4    Rogler, C.E.5
  • 23
    • 0141763760 scopus 로고    scopus 로고
    • The contribution of in vivo manipulation of gene expression to the understanding of the function of glypicans
    • 5142016 [pii]
    • Filmus J. The contribution of in vivo manipulation of gene expression to the understanding of the function of glypicans. Glycoconj J. 2002;19(4-5): 319-323 5142016 [pii].
    • (2002) Glycoconj J. , vol.19 , Issue.4-5 , pp. 319-323
    • Filmus, J.1
  • 24
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • 15829953 10.1038/nature03319 1:CAS:528:DC%2BD2MXjtFOmsrw%3D
    • Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature. 2005;434(7035):843-50.
    • (2005) Nature , vol.434 , Issue.7035 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 25
    • 0021242388 scopus 로고
    • Tumor heterogeneity
    • 6372991 1:STN:280:DyaL2c3gsFemtw%3D%3D
    • Heppner G. Tumor heterogeneity. Cancer Res. 1984;44(6):2259-65.
    • (1984) Cancer Res , vol.44 , Issue.6 , pp. 2259-2265
    • Heppner, G.1
  • 26
    • 0036699940 scopus 로고    scopus 로고
    • Molecular pathogenesis of human hepatocellular carcinoma
    • 12149612 10.1038/ng0802-339 1:CAS:528:DC%2BD38Xls1Oku7c%3D
    • Thorgeirsson SS, Grisham JW. Molecular pathogenesis of human hepatocellular carcinoma. Nat Genet. 2002;31(4):339-46.
    • (2002) Nat Genet , vol.31 , Issue.4 , pp. 339-346
    • Thorgeirsson, S.S.1    Grisham, J.W.2
  • 27
    • 36348991571 scopus 로고    scopus 로고
    • Activation of hepatic stem cell marker EpCAM by Wnt-beta-catenin signaling in hepatocellular carcinoma
    • 18006828 10.1158/0008-5472.CAN-07-0908 1:CAS:528:DC%2BD2sXhtlSlsL7N
    • Yamashita T, Budhu A, Forgues M, Wang XW. Activation of hepatic stem cell marker EpCAM by Wnt-beta-catenin signaling in hepatocellular carcinoma. Cancer Res. 2007;67(22):10831-9.
    • (2007) Cancer Res , vol.67 , Issue.22 , pp. 10831-10839
    • Yamashita, T.1    Budhu, A.2    Forgues, M.3    Wang, X.W.4
  • 28
    • 40449099255 scopus 로고    scopus 로고
    • EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma
    • 18316609 10.1158/0008-5472.CAN-07-6013 1:CAS:528:DC%2BD1cXislagu78%3D
    • Yamashita T, Forgues M, Wang W, Kim JW, Ye Q, Jia H, et al. EpCAM and alpha-fetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma. Cancer Res. 2008;68(5):1451-61.
    • (2008) Cancer Res , vol.68 , Issue.5 , pp. 1451-1461
    • Yamashita, T.1    Forgues, M.2    Wang, W.3    Kim, J.W.4    Ye, Q.5    Jia, H.6
  • 29
    • 60449087921 scopus 로고    scopus 로고
    • EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features
    • 19150350 10.1053/j.gastro.2008.12.004 1:CAS:528:DC%2BD1MXjslSju78%3D
    • Yamashita T, Ji J, Budhu A, Forgues M, Yang W, Wang HY, et al. EpCAM-positive hepatocellular carcinoma cells are tumor-initiating cells with stem/progenitor cell features. Gastroenterology. 2009;136(3):1012-24.
    • (2009) Gastroenterology , vol.136 , Issue.3 , pp. 1012-1024
    • Yamashita, T.1    Ji, J.2    Budhu, A.3    Forgues, M.4    Yang, W.5    Wang, H.Y.6
  • 30
    • 0028954815 scopus 로고
    • Embryonic axis induction by the armadillo repeat domain of beta-catenin: Evidence for intracellular signaling
    • 7876319 10.1083/jcb.128.5.959 1:CAS:528:DyaK2MXktVGqtbk%3D
    • Funayama N, Fagotto F, McCrea P, Gumbiner BM. Embryonic axis induction by the armadillo repeat domain of beta-catenin: evidence for intracellular signaling. J Cell Biol. 1995;128(5):959-68.
    • (1995) J Cell Biol , vol.128 , Issue.5 , pp. 959-968
    • Funayama, N.1    Fagotto, F.2    McCrea, P.3    Gumbiner, B.M.4
  • 31
    • 0036379830 scopus 로고    scopus 로고
    • Beta-catenin expression in hepatocellular carcinoma: A possible participation of beta-catenin in the dedifferentiation process
    • 12167121 10.1046/j.1440-1746.2002.02774.x 1:CAS:528:DC%2BD38XotFKhtrw%3D
    • Suzuki T, Yano H, Nakashima Y, Nakashima O, Kojiro M. Beta-catenin expression in hepatocellular carcinoma: a possible participation of beta-catenin in the dedifferentiation process. J Gastroenterol Hepatol. 2002;17(9):994-1000.
    • (2002) J Gastroenterol Hepatol , vol.17 , Issue.9 , pp. 994-1000
    • Suzuki, T.1    Yano, H.2    Nakashima, Y.3    Nakashima, O.4    Kojiro, M.5
  • 32
    • 0032885751 scopus 로고    scopus 로고
    • Nuclear accumulation of mutated beta-catenin in hepatocellular carcinoma is associated with increased cell proliferation
    • 10487827 10.1016/S0002-9440(10)65168-1 1:STN:280:DyaK1MvhvFaltA%3D%3D
    • Nhieu JT, Renard CA, Wei Y, Cherqui D, Zafrani ES, Buendia MA. Nuclear accumulation of mutated beta-catenin in hepatocellular carcinoma is associated with increased cell proliferation. Am J Pathol. 1999;155(3):703-10.
    • (1999) Am J Pathol , vol.155 , Issue.3 , pp. 703-710
    • Nhieu, J.T.1    Renard, C.A.2    Wei, Y.3    Cherqui, D.4    Zafrani, E.S.5    Buendia, M.A.6
  • 33
    • 0034495080 scopus 로고    scopus 로고
    • Beta-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis
    • 10980116 10.1016/S0002-9440(10)64590-7 1:CAS:528:DC%2BD3cXmvFWqt78%3D
    • Hsu HC, Jeng YM, Mao TL, Chu JS, Lai PL, Peng SY. Beta-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis. Am J Pathol. 2000;157(3):763-70.
    • (2000) Am J Pathol , vol.157 , Issue.3 , pp. 763-770
    • Hsu, H.C.1    Jeng, Y.M.2    Mao, T.L.3    Chu, J.S.4    Lai, P.L.5    Peng, S.Y.6
  • 34
    • 0034746832 scopus 로고    scopus 로고
    • Expression of mutant nuclear beta-catenin correlates with non-invasive hepatocellular carcinoma, absence of portal vein spread, and good prognosis
    • 11169521 10.1002/1096-9896(2000)9999:9999<: AID-PATH720>3.0.CO;2-3 1:CAS:528:DC%2BD3MXntVemsA%3D%3D
    • Mao TL, Chu JS, Jeng YM, Lai PL, Hsu HC. Expression of mutant nuclear beta-catenin correlates with non-invasive hepatocellular carcinoma, absence of portal vein spread, and good prognosis. J Pathol. 2001;193(1):95-101.
    • (2001) J Pathol. , vol.193 , Issue.1 , pp. 95-101
    • Mao, T.L.1    Chu, J.S.2    Jeng, Y.M.3    Lai, P.L.4    Hsu, H.C.5
  • 35
    • 0034995765 scopus 로고    scopus 로고
    • Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis
    • 11375957 10.1053/gast.2001.24798 1:CAS:528:DC%2BD3MXkslGku7Y%3D
    • Laurent-Puig P, Legoix P, Bluteau O, Belghiti J, Franco D, Binot F, et al. Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis. Gastroenterology. 2001;120(7):1763-73.
    • (2001) Gastroenterology , vol.120 , Issue.7 , pp. 1763-1773
    • Laurent-Puig, P.1    Legoix, P.2    Bluteau, O.3    Belghiti, J.4    Franco, D.5    Binot, F.6
  • 36
    • 33645227117 scopus 로고    scopus 로고
    • Zonal gene expression in murine liver: Lessons from tumors
    • 16496347 10.1002/hep.21082 1:CAS:528:DC%2BD28XjtVKqsL8%3D
    • Hailfinger S, Jaworski M, Braeuning A, Buchmann A, Schwarz M. Zonal gene expression in murine liver: lessons from tumors. Hepatology. 2006;43(3):407-14.
    • (2006) Hepatology , vol.43 , Issue.3 , pp. 407-414
    • Hailfinger, S.1    Jaworski, M.2    Braeuning, A.3    Buchmann, A.4    Schwarz, M.5
  • 37
    • 29744470059 scopus 로고    scopus 로고
    • Diagnostic and pathogenetic implications of the expression of hepatic transporters in focal lesions occurring in normal liver
    • 16161006 10.1002/path.1852 1:CAS:528:DC%2BD2MXhtlCks7bN
    • Vander Borght S, Libbrecht L, Blokzijl H, Faber KN, Moshage H, Aerts R, et al. Diagnostic and pathogenetic implications of the expression of hepatic transporters in focal lesions occurring in normal liver. J Pathol. 2005;207(4):471-82.
    • (2005) J Pathol. , vol.207 , Issue.4 , pp. 471-482
    • Vander Borght, S.1    Libbrecht, L.2    Blokzijl, H.3    Faber, K.N.4    Moshage, H.5    Aerts, R.6
  • 38
    • 44649146372 scopus 로고    scopus 로고
    • The beta-catenin pathway is activated in focal nodular hyperplasia but not in cirrhotic FNH-like nodules
    • 18466996 10.1016/j.jhep.2008.03.013 1:CAS:528:DC%2BD1cXmvFels7Y%3D
    • Rebouissou S, Couchy G, Libbrecht L, Balabaud C, Imbeaud S, Auffray C, et al. The beta-catenin pathway is activated in focal nodular hyperplasia but not in cirrhotic FNH-like nodules. J Hepatol. 2008;49(1):61-71.
    • (2008) J Hepatol , vol.49 , Issue.1 , pp. 61-71
    • Rebouissou, S.1    Couchy, G.2    Libbrecht, L.3    Balabaud, C.4    Imbeaud, S.5    Auffray, C.6
  • 39
    • 80051806849 scopus 로고    scopus 로고
    • Expression of SLCO1B3 is associated with intratumoral cholestasis and CTNNB1 mutations in hepatocellular carcinoma
    • 21615622 10.1111/j.1349-7006.2011.01990.x 1:CAS:528:DC%2BC3MXht1ant7fP
    • Sekine S, Ogawa R, Ojima H, Kanai Y. Expression of SLCO1B3 is associated with intratumoral cholestasis and CTNNB1 mutations in hepatocellular carcinoma. Cancer Sci. 2011;102(9):1742-7.
    • (2011) Cancer Sci , vol.102 , Issue.9 , pp. 1742-1747
    • Sekine, S.1    Ogawa, R.2    Ojima, H.3    Kanai, Y.4
  • 40
    • 0242609884 scopus 로고    scopus 로고
    • Cytokeratin 19 expression in hepatocellular carcinoma predicts early postoperative recurrence
    • 14556657 10.1111/j.1349-7006.2003.tb01366.x 1:CAS:528: DC%2BD3sXpsFGhtL4%3D
    • Uenishi T, Kubo S, Yamamoto T, Shuto T, Ogawa M, Tanaka H, et al. Cytokeratin 19 expression in hepatocellular carcinoma predicts early postoperative recurrence. Cancer Sci. 2003;94(10):851-7.
    • (2003) Cancer Sci , vol.94 , Issue.10 , pp. 851-857
    • Uenishi, T.1    Kubo, S.2    Yamamoto, T.3    Shuto, T.4    Ogawa, M.5    Tanaka, H.6
  • 41
    • 0029794269 scopus 로고    scopus 로고
    • Classification of hepatocellular carcinoma according to hepatocellular and biliary differentiation markers. Clinical and biological implications
    • 8863666 1:STN:280:DyaK2s%2FhslSmsQ%3D%3D
    • Wu P, Fang J, Lau V, Lai C, Lo C, Lau J. Classification of hepatocellular carcinoma according to hepatocellular and biliary differentiation markers. Clinical and biological implications. Am J Pathol. 1996;149(4):1167-75.
    • (1996) Am J Pathol , vol.149 , Issue.4 , pp. 1167-1175
    • Wu, P.1    Fang, J.2    Lau, V.3    Lai, C.4    Lo, C.5    Lau, J.6
  • 42
    • 52449093970 scopus 로고    scopus 로고
    • Cytokeratin 10 and cytokeratin 19: Predictive markers for poor prognosis in hepatocellular carcinoma patients after curative resection
    • 18559605 10.1158/1078-0432.CCR-07-4338 1:CAS:528:DC%2BD1cXntlWrtrc%3D
    • Yang X, Xu Y, Shi G, Fan J, Zhou J, Ji Y, et al. Cytokeratin 10 and cytokeratin 19: predictive markers for poor prognosis in hepatocellular carcinoma patients after curative resection. Clin Cancer Res. 2008;14(12):3850-9.
    • (2008) Clin Cancer Res , vol.14 , Issue.12 , pp. 3850-3859
    • Yang, X.1    Xu, Y.2    Shi, G.3    Fan, J.4    Zhou, J.5    Ji, Y.6
  • 43
    • 67650648501 scopus 로고    scopus 로고
    • Glypican-3 expression is correlated with poor prognosis in hepatocellular carcinoma
    • 19496787 10.1111/j.1349-7006.2009.01206.x 1:CAS:528:DC%2BD1MXhtVWnsLrJ
    • Shirakawa H, Suzuki H, Shimomura M, Kojima M, Gotohda N, Takahashi S, et al. Glypican-3 expression is correlated with poor prognosis in hepatocellular carcinoma. Cancer Sci. 2009;100(8):1403-7.
    • (2009) Cancer Sci , vol.100 , Issue.8 , pp. 1403-1407
    • Shirakawa, H.1    Suzuki, H.2    Shimomura, M.3    Kojima, M.4    Gotohda, N.5    Takahashi, S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.