Intravenous infusion of phage-displayed antibody library in human cancer patients: Enrichment and cancer-specificity of tumor-homing phage-antibodies

Cancer Immunology, Immunotherapy

Volumn 62, Issue 8, 2013, Pages 1397-1410

  Shukla, Girja S ^a   Krag, David N ^a   Peletskaya, Elena N ^a,c   Pero, Stephanie C ^a   Sun, Yu Jing ^a   Carman, Chelsea L ^a   McCahill, Laurence E ^a,d   Roland, Thomas A ^a,b  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b FLETCHER ALLEN HEALTH CARE   (United States)

^c Biolinx LLC   (United States)

^d Saint Mary's Health Care   (United States)

Author keywords

Antibodies; Cancer specific ligands; Human phage infusion safety; Phage displayed library; Target identification; Targeted therapy

Indexed keywords

AMINO ACID; CANCER ANTIBODY; CYTOKINE ANTIBODY; INTERLEUKIN 17A ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG;

ADULT; AGED; ANTIBODY LIBRARY; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ANTIGEN ANTIBODY REACTION; ANTIGEN BINDING; ARTICLE; BREAST; CANCER PATIENT; CANCER STAGING; CANCER SURGERY; CHONDROSARCOMA; CLINICAL ARTICLE; COLON; COLORECTAL CANCER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DNA SEQUENCE; HUMAN; HUMAN CELL; HUMAN TISSUE; KIDNEY PARENCHYMA; LIVER; LYMPHOMA; MALIGNANT NEOPLASTIC DISEASE; MELANOMA; MOLECULAR CLONING; PHAGE DISPLAY; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; PROTEIN MOTIF; SKIN; SPLEEN; UTERINE CERVIX; UTERUS;

ADULT; AMINO ACID SEQUENCE; ANTIBODIES, NEOPLASM; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; FOLLOW-UP STUDIES; HUMANS; IMMUNOGLOBULIN G; INFUSIONS, INTRAVENOUS; INTERLEUKIN-17; MOLECULAR SEQUENCE DATA; NEOPLASM STAGING; NEOPLASMS; PEPTIDE LIBRARY; PROTEIN BINDING; SEQUENCE HOMOLOGY, AMINO ACID; SINGLE-CHAIN ANTIBODIES;

EID: 84880918459     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-013-1443-5     Document Type: Article

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