Ozone ameliorates methotrexate-induced intestinal injury in rats

Cancer Biology and Therapy

Volumn 8, Issue 17, 2009, Pages 1623-1628

  Kesik, Vural ^a   Uysal, Bulent ^a   Kurt, Bulent ^a   Kismet, Erol ^a   Koseoglu, Vedat ^a  

^a GULHANE SCHOOL OF MEDICINE   (Turkey)

Author keywords

Intestinal injury; Lipid peroxidation; Liver and kidney injury; Methotrexate; Mucositis; Oxidant stress; Ozone therapy

Indexed keywords

GLUTATHIONE PEROXIDASE; MALONALDEHYDE; METHOTREXATE; OZONE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BOWMAN CAPSULE; CELL DEGENERATION; CELL VACUOLE; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFICACY; GLOMERULUS; HISTOPATHOLOGY; ILEUM; INTESTINAL BLEEDING; INTESTINE CRYPT; INTESTINE INJURY; INTESTINE VILLUS; KIDNEY HOMOGENATE; KUPFFER CELL; LAMINA PROPRIA; LIVER CELL; LIVER HOMOGENATE; LIVER SINUSOID; MALE; MONONUCLEAR CELL; MORTALITY; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS; OZONE THERAPY; PREMEDICATION; RAT; SHAM PROCEDURE; SURVIVAL;

ANIMALS; DISEASE MODELS, ANIMAL; GLUTATHIONE PEROXIDASE; ILEUM; INTESTINAL DISEASES; KIDNEY; LIVER; MALONDIALDEHYDE; METHOTREXATE; OXIDATIVE STRESS; OZONE; RATS;

EID: 70350266573     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.8.17.9203     Document Type: Article

References (25)

1. Yuncu M, Eralp A, Koruk M, Sari I, Bagci C, Inaloz S. Effect of vitamin A against methotrexate-induced damage to the small intestine in rats. Med Princ Pract 2004; 13:346-352 (Pubitemid 39370434)
2. Miyazono Y, Gao F, Horie T. Oxidative stress contributes to methotrexate-induced small intestinal toxicity in rats. Scand J Gastroenterol 2004; 39:1119-1127 (Pubitemid 39536402)
3. Phillips DC, Woollard KJ, Griffiths HR. The anti-inflammatory actions of methotrexate are critically dependent upon the production of reactive oxygen species. Br J Pharmacol 2003; 138:501-511
4. Huang CC, Hsu PC, Hung YC, Liao YF, Liu CC, Hour CT, et al. Ornithine decarboxylase prevents methotrexate-induced apoptosis by reducing intracellular reactive oxygen species production. Apoptosis 2005; 10:895-907. (Pubitemid 41187087)
5. Ciralik H, Bulbuloglu E, Cetinkaya A, Kurutas EB, Celik M, Polat A. Effects of N-acetylcysteine on methotrexate-induced small intestinal damage in rats. Mt Sinai J Med 2006; 73:1086-1092 (Pubitemid 46370340)
6. van't Land B, van Beek NM, van den Berg JJ, M'Rabet L. Lactoferrin reduces methotrexate-induced small intestinal damage, possibly through inhibition of GLP-2-mediated epithelial cell proliferation. Dig Dis Sci 2004; 49:425-433
7. Jahovic N, Sener G, Cevik H, Ersoy Y, Arbak S, Yegen BC. Amelioration of methotrexate-induced enteritis by melatonin in rats. Cell Biochem Funct 2004; 22:169-178 (Pubitemid 38659618)
8. Gao F, Nakamaru M, Masubuchi Y, Horie T. Protective effect of a synthetic analog of prostaglandin E(1) on the small intestinal damage induced by the administration of methotrexate to rats. J Pharm Sci 2001; 90:1040-1048
9. Horie T, Matsumoto H, Kasagi M, Sugiyama A, Kikuchi M, Karasawa C, et al. Protective effect of aged garlic extract on the small intestinal damage of rats induced by methotrexate administration. Planta Med 1999; 65:545-548 (Pubitemid 29399958)
10. Knoch HG, Klug W. Ozone-oxygen therapy in proctology. Ter Arkh 1990; 62:93-98
11. Zamora Z, Gonzalez R, Guanche D, Merino N, Menendez S, Hernandez F, et al. Ozonized sunflower oil reduces oxidative damage induced by indomethacin in rat gastric mucosa. Inflamm Res 2008; 57:39-43. (Pubitemid 351164887)
12. Bulynin VI, Glukhov AA. Treatment of peritonitis using ozone and hydropressive technology. Khirurgiia (Mosk) 1999; 7:9-11.
13. Leon OS, Menendez S, Merino N, Castillo R, Sam S, Perez L, et al. Ozone oxidative preconditioning: a protection against cellular damage by free radicals. Mediators Inflamm 1998; 7:289-294 (Pubitemid 28419524)
14. Bocci VA. Scientific and medical aspects of ozone therapy. State of the art. Arch Med Res 2006; 37:425-435
15. Borrego A, Zamora ZB, Gonzalez R, Romay C, Menendez S, Hernandez F, et al. Protection by ozone preconditioning is mediated by the antioxidant system in cisplatin-induced nephrotoxicity in rats. Mediators Inflamm 2004; 13:13-19 (Pubitemid 38621644)
16. Chen H, Xing B, Liu X, Zhan B, Zhou J, Zhu H, et al. Ozone oxidative preconditioning inhibits inflammation and apoptosis in a rat model of renal ischemia/reperfusion injury. Eur J Pharmacol 2008; 581:306-314
17. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951; 193:265-275
18. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979; 95:351-358 (Pubitemid 9194347)
19. Sun Y, Oberley LW, Li Y. A simple method for clinical assay of superoxide dismutase. Clin Chem 1988; 34:497-500. (Pubitemid 18102175)
20. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967; 70:158-169
21. Cetiner M, Sener G, Sehirli AO, Eksioglu-Demiralp E, Ercan F, Sirvanci S, et al. Taurine protects against methotrexate-induced toxicity and inhibits leukocyte death. Toxicol Appl Pharmacol 2005; 209:39-50. (Pubitemid 41547216)
22. Guven A, Gundogdu G, Sadir S, Topal T, Erdogan E, Korkmaz A, et al. The efficacy of ozone therapy in experimental caustic esophageal burn. J Pediatr Surg 2008; 43:1679-1684
23. Martinez-Sanchez G, Al-Dalain SM, Menendez S, Re L, Giuliani A, Candelario-Jalil E, et al. Therapeutic efficacy of ozone in patients with diabetic foot. Eur J Pharmacol 2005; 523:151-161 (Pubitemid 41562387)
24. Clavo B, Gutierrez D, Martin D, Suarez G, Hernandez MA, Robaina F. Intravesical ozone therapy for progressive radiation-induced hematuria. J Altern Complement Med 2005; 11:539-541 (Pubitemid 40994592)
25. Ajamieh HH, Menendez S, Martinez-Sanchez G, Candelario-Jalil E, Re L, Giuliani A, et al. Effects of ozone oxidative preconditioning on nitric oxide generation and cellular redox balance in a rat model of hepatic ischaemia-reperfusion. Liver Int 2004; 24:55-62. (Pubitemid 38351214)