Folinic acid protects against suppression of growth by methotrexate in mice

Biopharmaceutics and Drug Disposition

Volumn 22, Issue 4, 2001, Pages 169-178

  Perwaiz Iqbal, M ^a   Sultana, Fakhara ^a   Mehboobali, Naseema ^a   Pervez, Shahid ^a  

^a AGA KHAN UNIVERSITY   (Pakistan)

Author keywords

Citrovorum factor; Folate antagonists; Folinic acid; Growth of mice; Methotrexate; Suppression of growth

Indexed keywords

DIHYDROFOLATE REDUCTASE; FOLINIC ACID; METHOTREXATE; SODIUM CHLORIDE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; BODY WEIGHT; CONTROLLED STUDY; DIET SUPPLEMENTATION; DNA SYNTHESIS; DRUG ACTIVITY; ENZYME ACTIVITY; FLUID INTAKE; FOOD INTAKE; GROWTH CURVE; GROWTH INHIBITION; INTESTINE VILLUS; JUVENILE RHEUMATOID ARTHRITIS; KIDNEY; LIVER; MALABSORPTION; MALE; MORPHOLOGY; MOUSE; MOUSE STRAIN; NONHUMAN; ORGAN WEIGHT; PROTECTION; RISK; SMALL INTESTINE; SPLEEN; STATISTICAL ANALYSIS;

ANIMALS; ANTIDOTES; BODY WEIGHT; EATING; FOLIC ACID ANTAGONISTS; GROWTH DISORDERS; INTESTINE, SMALL; KIDNEY; LEUCOVORIN; LIVER; MALE; METHOTREXATE; MICE; MICE, INBRED BALB C; TETRAHYDROFOLATE DEHYDROGENASE;

EID: 0035207169     PISSN: 01422782     EISSN: None     Source Type: Journal    
DOI: 10.1002/bdd.271     Document Type: Article

References (26)

1. The pharmacology and clinical use of methotrexate
2. Methotrexate in resistant juvenile rheumatoid arthritis-results of the USA-USSR double-blind, placebo-controlled trial
3. Methotrexate safety in juvenile rheumatoid arthritis (JRA)
4. Safety and efficacy of methotrexate therapy for juvenile rheumatoid arthritis
5. Methotrexate for juvenile rheumatoid arthritis
6. Low dose methotrexate in recalcitrant JRA-results of the USA-USSR randomized controlled trial
7. High-dose methotrexate causes short term suppression of growth in rabbits
8. Effects of methotrexate on rat liver regeneration after partial hepatectomy
9. Additive effect of indomethacin and methotrexate on suppression of growth in rats
10. Effect of folate compounds on the accumulation of methotrexate and the activity of dihydorfolate reductase in liver, kidney and small intestine of the mouse
11. Ligand-binding radioassay for the antifolate compounds. Application in patients receiving methotrexate
12. Protein measurement with the folin phenol reagent
13. Specific binding of 4-amino folic acid analogues by folic acid reductase
14. Mechanism of growth inhibition by methotrexate
15. Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey and man
16. Response, toxicity and pharmacokinetics of high-dose methotrexate (NSC-740) with citrovorum factor (NSC-3590) rescue for children with osteosarcoma and other malignant tumors
17. Pharmacokinetic basis for differences in methotrexate sensitivity of normal proliferative tissues in the mouse
18. Effect of folinic acid on tissue residence of methotrexate in rats
19. The use of leucovorin orally in normal and leukemic L1210 mice to prevent the toxicity and gastrointestinal lesions caused by high doses of methotrexate
20. Metabolic consequences of methotrexate therapy in tumour-bearing rats
21. Gut bacterial translocation/dissemination explains the increased mortality produced by parenteral nutrition following methotrexate
22. The effect of methotrexate on mouse bone cells in culture
23. Growth failure and growth hormone deficiency after treatment for acute lymphoblastic leukaemia
24. Growth in children treated for acute lymphoblastic leukaemia