Synthesis and broad spectrum antiviral evaluation of bis(POM) prodrugs of novel acyclic nucleosides

European Journal of Medicinal Chemistry

Volumn 67, Issue , 2013, Pages 398-408

  Hamada, Manabu ^a   Roy, Vincent ^a   McBrayer, Tamara R ^b   Whitaker, Tony ^b   Urbina Blanco, Cesar ^c   Nolan, Steven P ^c   Balzarini, Jan ^d   Snoeck, Robert ^d   Andrei, Graciela ^d   Schinazi, Raymond F ^e   Agrofoglio, Luigi A ^a  

^a UNIVERSITÉ D'ORLÉANS   (France)

^b RFS Pharma LLC   (United States)

^c UNIVERSITY OF ST ANDREWS   (United Kingdom)

^d REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^e EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antiviral properties; Modified heterocycles; Nucleosides; Olefin cross metathesis; Synthesis

Indexed keywords

1 [4' BIS(PIVALOYLOXYMETHYL)PHOSPHINYLBUT 2' ENYL] 4 (CARBOXYLIC ACID) 1,2,3 TRIAZOLE; 1 [4' BIS(PIVALOYLOXYMETHYL)PHOSPHINYLBUT 2' ENYL] 4 (HYDROXYMETHYL) 1,2,3 TRIAZOLE; ACYCLIC NUCLEOSIDE; ANTIVIRUS AGENT; CIDOFOVIR; GANCICLOVIR; N 1 [4' BIS(PIVALOYLOXYMETHYL)PHOSPHINYL 2' BUTENYL] CYTOSINE; N 1 [4' BIS(PIVALOYLOXYMETHYL)PHOSPHINYLBUT 2' ENYL] 3 OXO PYRAZINE 2 CARBOXAMIDE; N 1 [4' BIS(PIVALOYLOXYMETHYL)PHOSPHINYLBUT 2' ENYL] 3 OXO PYRAZINE 2 METHYLESTER; PRODRUG; UNCLASSIFIED DRUG;

ALKYLATION; ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION (PARAMETERS); COXSACKIE VIRUS B4; CYCLOADDITION; CYTOSTASIS; DECARBOXYLATION; DRUG CYTOTOXICITY; DRUG SYNTHESIS; HEPATITIS C VIRUS; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; IN VITRO STUDY; MICROWAVE IRRADIATION; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; VARICELLA ZOSTER VIRUS; VERO CELL;

ANTIVIRAL PROPERTIES; CC(50); COMPOUND CONCENTRATION AFFORDING 50% INHIBITION OF CELL GROWTH; COMPOUND CONCENTRATION AFFORDING 50% INHIBITION OF THE VIRAL CYTOPATHICITY; DEOXYRIBONUCLEIC ACID; DNA; EC(50); HERPES SIMPLEX VIRUS; HSV; MADIN-DARBY CANINE KIDNEY; MCC; MDCK; MINIMUM CYTOTOXIC CONCENTRATION REQUIRED TO AFFORD A MICROSCOPICALLY DETECTABLE ALTERATION OF CELL MORPHOLOGY; MODIFIED HETEROCYCLES; NUCLEOSIDES; OLEFIN CROSS METATHESIS; RIBONUCLEIC ACID; RNA; SYNTHESIS; VACCINIA VIRUS; VARICELLA ZOSTER VIRUS; VESICULAR STOMATITIS VIRUS; VSV; VV; VZV;

ANTIVIRAL AGENTS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; NUCLEOSIDES; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUSES;

EID: 84880902014     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.06.053     Document Type: Article

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