-
1
-
-
33846899456
-
Restoration of p53 function leads to tumour regression in vivo
-
Ventura A, Kirsch DG, McLaughlin ME, et al. Restoration of p53 function leads to tumour regression in vivo. Nature. 2007;445(7128):661-665.
-
(2007)
Nature
, vol.445
, Issue.7128
, pp. 661-665
-
-
Ventura, A.1
Kirsch, D.G.2
McLaughlin, M.E.3
-
2
-
-
33846937033
-
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
-
Xue W, Zender L, Miething C, et al. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature. 2007;445(7128):656-660.
-
(2007)
Nature
, vol.445
, Issue.7128
, pp. 656-660
-
-
Xue, W.1
Zender, L.2
Miething, C.3
-
4
-
-
73849107145
-
Tumor protein 53 mutations and inherited cancer: Beyond Li-Fraumeni syndrome
-
Palmero EI, Achatz MI, Ashton-Prolla P, Olivier M, Hainaut P. Tumor protein 53 mutations and inherited cancer: beyond Li-Fraumeni syndrome. Curr Opin Oncol. 2010;22(1):64-69.
-
(2010)
Curr Opin Oncol.
, vol.22
, Issue.1
, pp. 64-69
-
-
Palmero, E.I.1
Achatz, M.I.2
Ashton-Prolla, P.3
Olivier, M.4
Hainaut, P.5
-
6
-
-
10944236962
-
Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome
-
Olive KP, Tuveson DA, Ruhe ZC, et al. Mutant p53 gain of function in two mouse models of Li-Fraumeni syndrome. Cell. 2004;119(6): 847-860.
-
(2004)
Cell.
, vol.119
, Issue.6
, pp. 847-860
-
-
Olive, K.P.1
Tuveson, D.A.2
Ruhe, Z.C.3
-
7
-
-
13644260907
-
Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome
-
Lang GA, Iwakuma T, Suh YA, et al. Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell. 2004; 119(6):861-872.
-
(2004)
Cell.
, vol.119
, Issue.6
, pp. 861-872
-
-
Lang, G.A.1
Iwakuma, T.2
Suh, Y.A.3
-
8
-
-
7144250518
-
Role of a p53 polymorphism in the development of human papillomavirus-associated cancer
-
Storey A, Thomas M, Kalita A, et al. Role of a p53 polymorphism in the development of human papillomavirus-associated cancer. Nature. 1998; 393(6682):229-234.
-
(1998)
Nature
, vol.393
, Issue.6682
, pp. 229-234
-
-
Storey, A.1
Thomas, M.2
Kalita, A.3
-
9
-
-
77951010885
-
Aggressive lymphomas
-
Lenz G, Staudt LM. Aggressive lymphomas. N Engl J Med. 2010;362(15):1417-1429.
-
(2010)
N Engl J Med.
, vol.362
, Issue.15
, pp. 1417-1429
-
-
Lenz, G.1
Staudt, L.M.2
-
10
-
-
79955835059
-
Pathogenesis of non-Hodgkin's lymphoma
-
Nogai H, Dörken B, Lenz G. Pathogenesis of non-Hodgkin's lymphoma. J Clin Oncol. 2011;29(14): 1803-1811.
-
(2011)
J Clin Oncol.
, vol.29
, Issue.14
, pp. 1803-1811
-
-
Nogai, H.1
Dörken, B.2
Lenz, G.3
-
11
-
-
80052269038
-
Analysis of the coding genome of diffuse large B-cell lymphoma
-
Pasqualucci L, Trifonov V, Fabbri G, et al. Analysis of the coding genome of diffuse large B-cell lymphoma. Nat Genet. 2011;43(9):830-837.
-
(2011)
Nat Genet.
, vol.43
, Issue.9
, pp. 830-837
-
-
Pasqualucci, L.1
Trifonov, V.2
Fabbri, G.3
-
12
-
-
80052029516
-
Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma
-
Morin RD, Mendez-Lago M, Mungall AJ, et al. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma. Nature. 2011;476(7360): 298-303.
-
(2011)
Nature
, vol.476
, Issue.7360
, pp. 298-303
-
-
Morin, R.D.1
Mendez-Lago, M.2
Mungall, A.J.3
-
13
-
-
84857942952
-
Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing
-
Lohr JG, Stojanov P, Lawrence MS, et al. Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing. Proc Natl Acad Sci USA. 2012;109(10):3879-3884.
-
(2012)
Proc Natl Acad Sci USA.
, vol.109
, Issue.10
, pp. 3879-3884
-
-
Lohr, J.G.1
Stojanov, P.2
Lawrence, M.S.3
-
14
-
-
0034676455
-
Surfing the p53 network
-
Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature. 2000;408(6810):307-310.
-
(2000)
Nature
, vol.408
, Issue.6810
, pp. 307-310
-
-
Vogelstein, B.1
Lane, D.2
Levine, A.J.3
-
15
-
-
79952699255
-
P53: The most frequently altered gene in human cancers
-
Vogelstein B, Sur S, Prives C. p53: the most frequently altered gene in human cancers. Nature Education. 2010;3(9):6.
-
(2010)
Nature Education.
, vol.3
, Issue.9
, pp. 6
-
-
Vogelstein, B.1
Sur, S.2
Prives, C.3
-
16
-
-
54049126176
-
Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: An international collaborative study
-
Young KH, Leroy K, Møller MB, et al. Structural profiles of TP53 gene mutations predict clinical outcome in diffuse large B-cell lymphoma: an international collaborative study. Blood. 2008; 112(8):3088-3098.
-
(2008)
Blood
, vol.112
, Issue.8
, pp. 3088-3098
-
-
Young, K.H.1
Leroy, K.2
Møller, M.B.3
-
17
-
-
84868602463
-
Mutational profile and prognostic significance of TP53 in diffuse large B-cell lymphoma patients treated with R-CHOP: Report from an International DLBCL Rituximab-CHOP Consortium Program Study
-
Xu-Monette ZY, Wu L, Visco C, et al. Mutational profile and prognostic significance of TP53 in diffuse large B-cell lymphoma patients treated with R-CHOP: report from an International DLBCL Rituximab-CHOP Consortium Program Study. Blood. 2012;120(19):3986-3996.
-
(2012)
Blood
, vol.120
, Issue.19
, pp. 3986-3996
-
-
Xu-Monette, Z.Y.1
Wu, L.2
Visco, C.3
-
18
-
-
78650858038
-
MiR-301a as an NF-kB activator in pancreatic cancer cells
-
Lu Z, Li Y, Takwi A, et al. miR-301a as an NF-kB activator in pancreatic cancer cells. EMBO J. 2011;30(1):57-67.
-
(2011)
EMBO J.
, vol.30
, Issue.1
, pp. 57-67
-
-
Lu, Z.1
Li, Y.2
Takwi, A.3
-
19
-
-
34248379012
-
Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: Lessons from recent developments in the IARC TP53 database
-
Petitjean A, Mathe E, Kato S, et al. Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database. Hum Mutat. 2007;28(6):622-629.
-
(2007)
Hum Mutat.
, vol.28
, Issue.6
, pp. 622-629
-
-
Petitjean, A.1
Mathe, E.2
Kato, S.3
-
20
-
-
79951812882
-
Negative regulation of the tumor suppressor p53 gene by microRNAs
-
Kumar M, Lu Z, Takwi AAL, et al. Negative regulation of the tumor suppressor p53 gene by microRNAs. Oncogene. 2011;30(7):843-853.
-
(2011)
Oncogene.
, vol.30
, Issue.7
, pp. 843-853
-
-
Kumar, M.1
Lu, Z.2
Takwi, A.A.L.3
-
21
-
-
64349101658
-
MicroRNA-125b is a novel negative regulator of p53
-
Le MTN, Teh C, Shyh-Chang N, et al. MicroRNA-125b is a novel negative regulator of p53. Genes Dev. 2009;23(7):862-876.
-
(2009)
Genes Dev.
, vol.23
, Issue.7
, pp. 862-876
-
-
Le, M.T.N.1
Teh, C.2
Shyh-Chang, N.3
-
22
-
-
77953096272
-
Negative regulation of tumor suppressor p53 by microRNA miR-504
-
Hu W, Chan CS, Wu R, et al. Negative regulation of tumor suppressor p53 by microRNA miR-504. Mol Cell. 2010;38(5):689-699.
-
(2010)
Mol Cell.
, vol.38
, Issue.5
, pp. 689-699
-
-
Hu, W.1
Chan, C.S.2
Wu, R.3
-
23
-
-
77957764089
-
MiR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma
-
Swarbrick A, Woods SL, Shaw A, et al. miR-380-5p represses p53 to control cellular survival and is associated with poor outcome in MYCN-amplified neuroblastoma. Nat Med. 2010;16(10):1134-1140.
-
(2010)
Nat Med.
, vol.16
, Issue.10
, pp. 1134-1140
-
-
Swarbrick, A.1
Woods, S.L.2
Shaw, A.3
-
24
-
-
78649644924
-
MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states
-
Neveu P, Kye MJ, Qi S, et al. MicroRNA profiling reveals two distinct p53-related human pluripotent stem cell states. Cell Stem Cell. 2010;7(6): 671-681.
-
(2010)
Cell Stem Cell.
, vol.7
, Issue.6
, pp. 671-681
-
-
Neveu, P.1
Kye, M.J.2
Qi, S.3
-
25
-
-
84869067808
-
A systematic screen reveals MicroRNA clusters that significantly regulate four major signaling pathways
-
Becker LE, Lu Z, Chen W, Xiong W, Kong M, Li Y. A systematic screen reveals MicroRNA clusters that significantly regulate four major signaling pathways. PLoS ONE. 2012;7(11):e48474.
-
(2012)
PLoS ONE.
, vol.7
, Issue.11
, pp. e48474
-
-
Becker, L.E.1
Lu, Z.2
Chen, W.3
Xiong, W.4
Kong, M.5
Li, Y.6
-
26
-
-
77952875310
-
MicroRNA-1285 inhibits the expression of p53 by directly targeting its 39 untranslated region
-
Tian S, Huang S, Wu S, Guo W, Li J, He X. MicroRNA-1285 inhibits the expression of p53 by directly targeting its 39 untranslated region. Biochem Biophys Res Commun. 2010;396(2): 435-439.
-
(2010)
Biochem Biophys Res Commun.
, vol.396
, Issue.2
, pp. 435-439
-
-
Tian, S.1
Huang, S.2
Wu, S.3
Guo, W.4
Li, J.5
He, X.6
-
27
-
-
78650861867
-
Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia
-
Fabbri M, Bottoni A, Shimizu M, et al. Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia. JAMA. 2011;305(1):59-67.
-
(2011)
JAMA
, vol.305
, Issue.1
, pp. 59-67
-
-
Fabbri, M.1
Bottoni, A.2
Shimizu, M.3
-
28
-
-
60149095444
-
Most mammalian mRNAs are conserved targets of microRNAs
-
Friedman RC, Farh KK-H, Burge CB, Bartel DP. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 2009;19(1):92-105.
-
(2009)
Genome Res.
, vol.19
, Issue.1
, pp. 92-105
-
-
Friedman, R.C.1
Kk-H, F.2
Burge, C.B.3
Bartel, D.P.4
-
29
-
-
58249088751
-
MicroRNAs: Target recognition and regulatory functions
-
Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009;136(2):215-233.
-
(2009)
Cell.
, vol.136
, Issue.2
, pp. 215-233
-
-
Bartel, D.P.1
-
30
-
-
80055009292
-
A germline variant in the TP53 polyadenylation signal confers cancer susceptibility
-
Stacey SN, Sulem P, Jonasdottir A, et al. A germline variant in the TP53 polyadenylation signal confers cancer susceptibility. Nat Genet. 2011;43(11):1098-1103.
-
(2011)
Nat Genet.
, vol.43
, Issue.11
, pp. 1098-1103
-
-
Stacey, S.N.1
Sulem, P.2
Jonasdottir, A.3
-
31
-
-
68749113985
-
Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells
-
Mayr C, Bartel DP. Widespread shortening of 3'UTRs by alternative cleavage and polyadenylation activates oncogenes in cancer cells. Cell. 2009;138(4):673-684.
-
(2009)
Cell.
, vol.138
, Issue.4
, pp. 673-684
-
-
Mayr, C.1
Bartel, D.P.2
-
32
-
-
61749103876
-
Stability of eukaryotic translation initiation factor 4E mRNA is regulated by HuR, and this activity is dysregulated in cancer
-
Topisirovic I, Siddiqui N, Orolicki S, et al. Stability of eukaryotic translation initiation factor 4E mRNA is regulated by HuR, and this activity is dysregulated in cancer. Mol Cell Biol. 2009;29(5): 1152-1162.
-
(2009)
Mol Cell Biol.
, vol.29
, Issue.5
, pp. 1152-1162
-
-
Topisirovic, I.1
Siddiqui, N.2
Orolicki, S.3
-
33
-
-
70349320158
-
Causes and consequences of microRNA dysregulation in cancer
-
Croce CM. Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet. 2009;10(10):704-714.
-
(2009)
Nat Rev Genet.
, vol.10
, Issue.10
, pp. 704-714
-
-
Croce, C.M.1
-
34
-
-
37549015263
-
Germinal centres: Role in B-cell physiology and malignancy
-
Klein U, Dalla-Favera R. Germinal centres: role in B-cell physiology and malignancy. Nat Rev Immunol. 2008;8(1):22-33.
-
(2008)
Nat Rev Immunol.
, vol.8
, Issue.1
, pp. 22-33
-
-
Klein, U.1
Dalla-Favera, R.2
-
35
-
-
33644876453
-
SNP500Cancer: A public resource for sequence validation, assay development, and frequency analysis for genetic variation in candidate genes
-
Packer BR, Yeager M, Burdett L, et al. SNP500Cancer: a public resource for sequence validation, assay development, and frequency analysis for genetic variation in candidate genes. Nucleic Acids Res. 2006;34(Database issue suppl 1):D617-D621.
-
(2006)
Nucleic Acids Res.
, vol.34
, Issue.DATABASE ISSUE
, pp. D617-D621
-
-
Packer, B.R.1
Yeager, M.2
Burdett, L.3
-
36
-
-
80055009292
-
A germline variant in the TP53 polyadenylation signal confers cancer susceptibility
-
Stacey SN, Sulem P, Jonasdottir A, et al. Swedish Low-risk Colorectal Cancer Study Group. A germline variant in the TP53 polyadenylation signal confers cancer susceptibility. Nat Genet. 2011;43(11):1098-1103.
-
(2011)
Nat Genet.
, vol.43
, Issue.11
, pp. 1098-1103
-
-
Stacey, S.N.1
Sulem, P.2
Jonasdottir, A.3
-
37
-
-
84866028455
-
Integrative analysis reveals an outcome-associated and targetable pattern of p53 and cell cycle deregulation in diffuse large B cell lymphoma
-
Monti S, Chapuy B, Takeyama K, et al. Integrative analysis reveals an outcome-associated and targetable pattern of p53 and cell cycle deregulation in diffuse large B cell lymphoma. Cancer Cell. 2012;22(3):359-372.
-
(2012)
Cancer Cell.
, vol.22
, Issue.3
, pp. 359-372
-
-
Monti, S.1
Chapuy, B.2
Takeyama, K.3
-
38
-
-
34250877841
-
A mammalian microRNA expression atlas based on small RNA library sequencing
-
Landgraf P, Rusu M, Sheridan R, et al. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell. 2007;129(7): 1401-1414.
-
(2007)
Cell.
, vol.129
, Issue.7
, pp. 1401-1414
-
-
Landgraf, P.1
Rusu, M.2
Sheridan, R.3
-
39
-
-
77957252821
-
Comprehensive microRNA expression profiling of the hematopoietic hierarchy
-
Petriv OI, Kuchenbauer F, Delaney AD, et al. Comprehensive microRNA expression profiling of the hematopoietic hierarchy. Proc Natl Acad Sci USA. 2010;107(35):15443-15448.
-
(2010)
Proc Natl Acad Sci USA.
, vol.107
, Issue.35
, pp. 15443-15448
-
-
Petriv, O.I.1
Kuchenbauer, F.2
Delaney, A.D.3
-
40
-
-
79956089851
-
Ordered progression of stage-specific miRNA profiles in the mouse B2 B-cell lineage
-
Spierings DC, McGoldrick D, Hamilton-Easton AM, et al. Ordered progression of stage-specific miRNA profiles in the mouse B2 B-cell lineage. Blood. 2011; 117(20):5340-5349.
-
(2011)
Blood
, vol.117
, Issue.20
, pp. 5340-5349
-
-
Spierings, D.C.1
McGoldrick, D.2
Hamilton-Easton, A.M.3
-
41
-
-
66549101276
-
Patterns of microRNA expression characterize stages of human B-cell differentiation
-
Zhang J, Jima DD, Jacobs C, et al. Patterns of microRNA expression characterize stages of human B-cell differentiation. Blood. 2009;113(19): 4586-4594.
-
(2009)
Blood
, vol.113
, Issue.19
, pp. 4586-4594
-
-
Zhang, J.1
Jima, D.D.2
Jacobs, C.3
-
42
-
-
65549112644
-
Differentiation stage-specific expression of microRNAs in B lymphocytes and diffuse large B-cell lymphomas
-
Malumbres R, Sarosiek KA, Cubedo E, et al. Differentiation stage-specific expression of microRNAs in B lymphocytes and diffuse large B-cell lymphomas. Blood. 2009;113(16): 3754-3764.
-
(2009)
Blood
, vol.113
, Issue.16
, pp. 3754-3764
-
-
Malumbres, R.1
Sarosiek, K.A.2
Cubedo, E.3
-
43
-
-
26244459242
-
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin
-
Takagi M, Absalon MJ, McLure KG, Kastan MB. Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell. 2005;123(1):49-63.
-
(2005)
Cell.
, vol.123
, Issue.1
, pp. 49-63
-
-
Takagi, M.1
Absalon, M.J.2
McLure, K.G.3
Kastan, M.B.4
-
44
-
-
0038153919
-
RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation
-
Mazan-Mamczarz K, Galbán S, López de Silanes I, et al. RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation. Proc Natl Acad Sci USA. 2003; 100(14):8354-8359.
-
(2003)
Proc Natl Acad Sci USA.
, vol.100
, Issue.14
, pp. 8354-8359
-
-
Mazan-Mamczarz, K.1
Galbán, S.2
López De Silanes, I.3
-
45
-
-
84885708564
-
Genetic abnormalities in multiple myeloma
-
Kumar S, Abraham J, eds. New York, NY: Demos Medical Publishing
-
Chng WJ. Genetic abnormalities in multiple myeloma. In: Kumar S, Abraham J, eds. Multiple Myeloma. New York, NY: Demos Medical Publishing; 2010:215-236.
-
(2010)
Multiple Myeloma
, pp. 215-236
-
-
Chng, W.J.1
-
46
-
-
23944469845
-
Recent developments in genomewide association scans: A workshop summary and review
-
Thomas DC, Haile RW, Duggan D. Recent developments in genomewide association scans: a workshop summary and review. Am J Hum Genet. 2005;77(3):337-345.
-
(2005)
Am J Hum Genet.
, vol.77
, Issue.3
, pp. 337-345
-
-
Thomas, D.C.1
Haile, R.W.2
Duggan, D.3
-
47
-
-
84864538649
-
A functional germline variant in the P53 polyadenylation signal and risk of esophageal squamous cell carcinoma
-
Zhou L, Yuan Q, Yang M. A functional germline variant in the P53 polyadenylation signal and risk of esophageal squamous cell carcinoma. Gene. 2012;506(2):295-297.
-
(2012)
Gene.
, vol.506
, Issue.2
, pp. 295-297
-
-
Zhou, L.1
Yuan, Q.2
Yang, M.3
-
48
-
-
84864315118
-
Rare TP53 genetic variant associated with glioma risk and outcome
-
Egan KM, Nabors LB, Olson JJ, et al. Rare TP53 genetic variant associated with glioma risk and outcome. J Med Genet. 2012;49(7):420-421.
-
(2012)
J Med Genet.
, vol.49
, Issue.7
, pp. 420-421
-
-
Egan, K.M.1
Nabors, L.B.2
Olson, J.J.3
-
49
-
-
0021673231
-
Role of the conserved AAUAAA sequence: Four AAUAAA point mutants prevent messenger RNA 39 end formation
-
Wickens M, Stephenson P. Role of the conserved AAUAAA sequence: four AAUAAA point mutants prevent messenger RNA 39 end formation. Science. 1984;226(4678):1045-1051.
-
(1984)
Science.
, vol.226
, Issue.4678
, pp. 1045-1051
-
-
Wickens, M.1
Stephenson, P.2
-
50
-
-
0022751114
-
The AAUAAA sequence is required both for cleavage and for polyadenylation of simian virus 40 pre-mRNA in vitro
-
Zarkower D, Stephenson P, Sheets M, Wickens M. The AAUAAA sequence is required both for cleavage and for polyadenylation of simian virus 40 pre-mRNA in vitro. Mol Cell Biol. 1986;6(7): 2317-2323.
-
(1986)
Mol Cell Biol.
, vol.6
, Issue.7
, pp. 2317-2323
-
-
Zarkower, D.1
Stephenson, P.2
Sheets, M.3
Wickens, M.4
|