Genome sequencing and genetic mapping to dissect the genetic basis of complex traits;Nouvelle avancée dans notre connaissance des facteurs génétiques contribuant aux phénotypes complexes

Medecine/Sciences

Volumn 29, Issue 6-7, 2013, Pages 671-674

  Baud, Amelie ^a   Calderari, Sophie ^b   Mott, Richard ^a   Flint, Jonathan ^a   Gauguier, Dominique ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b CENTRE DE RECHERCHE DES CORDELIERS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; ARTICLE; CHROMOSOME MAP; GENOME; HUMAN; PHENOTYPE; RAT; SEQUENCE ANALYSIS;

ANIMALS; CHROMOSOME MAPPING; GENOME; HUMANS; PHENOTYPE; RATS; SEQUENCE ANALYSIS;

EID: 84880832819     PISSN: 07670974     EISSN: 19585381     Source Type: Journal    
DOI: 10.1051/medsci/2013296024     Document Type: Article

References (7)

1. Flint J, Mackay TF. Genetic architecture of quantitative traits in mice, flies, and humans. Genome research 2009; 19 : 723-33
2. Baud A, Hermsen R, Guryev V, et al. Combined sequence-based and genetic mapping analysis of complex traits in outbred rats. Nat Genet 2013; 26 mai, doi: 10.1038/ng.2644.
3. Hansen C, Spuhler K. Development of the National Institutes of Health genetically heterogeneous rat stock. Alcohol Clin Exp Res 1984; 8 : 477-9.
4. Johannesson M, Lopez-Aumatell R, Stridh P, et al. A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock. Genome Res 2009 ; 19 : 1 50-8.
5. Valdar W, Solberg LC, Gauguier D, et al. Genome-wide genetic association of complex traits in heterogeneous stock mice. Nat Genet 2006; 38 : 879-87.
6. Keane TM, Goodstadt L, Danecek P, et al. Mouse genomic variation and its effect on phenotypes and gene regulation. Nature 2011; 477 : 289-94.
7. Yalcin B, Flint J, Mott R. Using progenitor strain inf ormation to identify quantitative trait nucleotides in outbred mice. Genetics 2005; 171 : 673-81.