Insights on vitamin D's role in cardiovascular disease: Investigating the association of 25-hydroxyvitamin D with the dimethylated arginines

Journal of Nutritional Science and Vitaminology

Volumn 59, Issue 3, 2013, Pages 172-177

  Abu El Maaty, Mohamed A ^a   Hassanein, Sally I ^a   Hanafi, Rasha S ^b   Gad, Mohamed Z ^a  

^a German University in Cairo   (Egypt)

^b GERMAN UNIVERSITY IN CAIRO   (Egypt)

Author keywords

Cardiovascular disease; Dimethylated arginine; Endothelial dysfunction; Vitamin D

Indexed keywords

25 HYDROXYVITAMIN D; 6 N, N' DIMETHYLARGININE; ARGININE; C REACTIVE PROTEIN; N (G), N (G) DIMETHYLARGININE; NITRIC OXIDE; UNCLASSIFIED DRUG; VITAMIN D;

ADULT; ARTICLE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INFLAMMATION; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; SOLID PHASE EXTRACTION; SPECTROPHOTOMETRY; VITAMIN D DEFICIENCY;

EID: 84880827123     PISSN: 03014800     EISSN: 18817742     Source Type: Journal    
DOI: 10.3177/jnsv.59.172     Document Type: Article

References (26)

1. Holick MF. 2007. Vitamin D deficiency. N Engl J Med 357: 266-281.
2. Garcia VC, Martini LA. 2010. Vitamin D and cardiovascular disease. Nutrients 2: 426-437.
3. Molinari C, Uberti F, Grossini E, Vacca G, Carda S, Invernizzi M, Cisari C. 2011. 1alpha,25-dihydroxycholecalciferol induces nitric oxide production in cultured endothelial cells. Cell Physiol Biochem 27: 661-668.
4. Stojanovic OI, Lazovic M, Vuceljic M. 2011. Association between atherosclerosis and osteoporosis, the role of vitamin D. Arch Med Sci 7: 179-188.
5. Endemann DH, Schiffrin EL. 2004. Endothelial dysfunction. J Am Soc Nephrol 15: 1983-1992.
6. Boger RH. 2004. Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, explains the "L-arginine paradox" and acts as a novel cardiovascular risk factor. J Nutr 134: 2842S-2847S; discussion 53S.
7. Bode-Boger SM, Scalera F, Kielstein JT, Martens-Lobenhoffer J, Breithardt G, Fobker M, Reinecke H. 2006. Symmetrical dimethylarginine: a new combined parameter for renal function and extent of coronary artery disease. J Am Soc Nephrol 17: 1128-1134.
8. Clearfield MB. 2005. C-reactive protein: a new risk assessment tool for cardiovascular disease. J Am Osteopath Assoc 105: 409-416.
9. Witham MD, Dove FJ, Khan F, Lang CC, Belch JJ, Struthers AD. 2012. Effects of vitamin D supplementation on markers of vascular function after myocardial infarction-A randomised controlled trial. Int J Cardiol [Epub ahead of print].
10. Al-Daghri NM, Al-Attas OS, Alokail MS, Alkharfy KM, Al-Othman A, Draz HM, Yakout SM, Al-Saleh Y, Al- Yousef M, Sabico S, Clerici M, Chrousos GP. 2013. Hypovitaminosis D associations with adverse metabolic parameters are accentuated in patients with diabetes mellitus type 2: A BMI-independent role of adiponectin? J Endocrinol Invest 36: 1-6.
11. Makariou S, Liberopoulos E, Florentin M, Lagos K, Gazi I, Challa A, Elisaf M. 2012. The relationship of vitamin D with non-traditional risk factors for cardiovascular disease in subjects with metabolic syndrome. Arch Med Sci 8: 437-443.
12. Ertek S, Akgul E, Cicero AF, Kutuk U, Demirtas S, Cehreli S, Erdogan G. 2012. 25-Hydroxy vitamin D levels and endothelial vasodilator function in normotensive women. Arch Med Sci 8: 47-52.
13. Tarcin O, Yavuz DG, Ozben B, Telli A, Ogunc AV, Yuksel M, Toprak A, Yazici D, Sancak S, Deyneli O, Akalin S. 2009. Effect of vitamin D deficiency and replacement on endothelial function in asymptomatic subjects. J Clin Endocrinol Metab 94: 4023-4030.
14. Yiu YF, Chan YH, Yiu KH, Siu CW, Li SW, Wong LY, Lee SW, Tam S, Wong EW, Cheung BM, Tse HF. 2011. Vitamin D deficiency is associated with depletion of circulating endothelial progenitor cells and endothelial dysfunction in patients with type 2 diabetes. J Clin Endocrinol Metab 96: E830-835.
15. Ngo DT, Sverdlov AL, McNeil JJ, Horowitz JD. 2010. Does vitamin D modulate asymmetric dimethylarginine and C-reactive protein concentrations? Am J Med 123: 335-341.
16. Stevenson JC. 2011. A woman's journey through the reproductive, transitional and postmenopausal periods of life: impact on cardiovascular and musculo-skeletal risk and the role of estrogen replacement. Maturitas 70: 197-205.
17. Hollis BW, Frank NE. 1985. Solid phase extraction system for vitamin D and its major metabolites in human plasma. J Chromatogr 343: 43-49.
18. Bryan NS, Grisham MB. 2007. Methods to detect nitric oxide and its metabolites in biological samples. Free Radic Biol Med 43: 645-657.
19. Schwedhelm E, Tan-Andresen J, Maas R, Riederer U, Schulze F, Boger RH. 2005. Liquid chromatographytandem mass spectrometry method for the analysis of asymmetric dimethylarginine in human plasma. Clin Chem 51: 1268-1271.
20. Schwedhelm E, Maas R, Tan-Andresen J, Schulze F, Riederer U, Boger RH. 2007. High-throughput liquid chromatographic-tandem mass spectrometric determination of arginine and dimethylated arginine derivatives in human and mouse plasma. J Chromatogr B Analyt Technol Biomed Life Sci 851: 211-219.
21. Williams DM, Fraser A, Sayers A, Fraser WD, Hingorani A, Deanfield J, Davey Smith G, Sattar N, Lawlor DA. 2012. Associations of 25-hydroxyvitamin D2 and D3 with cardiovascular risk factors in childhood: crosssectional findings from the Avon Longitudinal Study of Parents and Children. J Clin Endocrinol Metab 97: 1563-1571.
22. Sugden JA, Davies JI, Witham MD, Morris AD, Struthers AD. 2008. Vitamin D improves endothelial function in patients with Type 2 diabetes mellitus and low vitamin D levels. Diabet Med 25: 320-325.
23. Stricker H, Tosi Bianda F, Guidicelli-Nicolosi S, Limoni C, Colucci G. 2012. Effect of a single, oral, high-dose vitamin D supplementation on endothelial function in patients with peripheral arterial disease: A randomised controlled pilot study. Eur J Vasc Endovasc Surg 44: 307-312.
24. Libby P, Ridker PM, Hansson GK. 2009. Inflammation in atherosclerosis: from pathophysiology to practice. J Am Coll Cardiol 54: 2129-2138.
25. Jablonski KL, Chonchol M, Pierce GL, Walker AE, Seals DR. 2011. 25-Hydroxyvitamin D deficiency is associated with inflammation-linked vascular endothelial dysfunction in middle-aged and older adults. Hypertension 57: 63-69.
26. Grossmann RE, Zughaier SM, Liu S, Lyles RH, Tangpricha V. 2012. Impact of vitamin D supplementation on markers of inflammation in adults with cystic fibrosis hospitalized for a pulmonary exacerbation. Eur J Clin Nutr 66: 1072-1074.