Modulating the Actin Cytoskeleton Affects Mechanically Induced Signal Transduction and Differentiation in Mesenchymal Stem Cells

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Müller, Petra ^a   Langenbach, Anne ^a   Kaminski, Alexander ^a   Rychly, Joachim ^a  

^a ROSTOCK UNIVERSITY MEDICAL CENTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; BETA1 INTEGRIN; CYTOCHALASIN D; JASPAMIDE; LATRUNCULIN A; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; VINCULIN;

ACTIN FILAMENT; ACTIN POLYMERIZATION; ARTICLE; CELL DIFFERENTIATION; CELL SHAPE; CELL STRUCTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MECHANICAL STRESS; MESENCHYMAL STEM CELL; OSTEOBLAST; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ACTIN CYTOSKELETON; ADIPOGENESIS; CELL DIFFERENTIATION; CYTOCHALASIN D; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MECHANOTRANSDUCTION, CELLULAR; MESENCHYMAL STROMAL CELLS; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 84880816823     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0071283     Document Type: Article

References (40)

1. Discher DE, Mooney DJ, Zandstra PW, (2009) Growth factors, matrices, and forces combine and control stem cells. Science 324: 1673-1677.
2. Guilak F, Cohen DM, Estes BT, Gimble JM, Liedtke W, et al. (2009) Control of stem cell fate by physical interactions with the extracellular matrix. Cell Stem Cell 5: 17-26.
3. Sun Y, Chen CS, Fu J, (2012) Forcing stem cells to behave: a biophysical perspective of the cellular microenvironment. Annu Rev Biophys 41: 519-542.
4. Nava MM, Raimondi MT, Pietrabissa R, (2012) Controlling self-renewal and differentiation of stem cells via mechanical cues. J Biomed Biotechnol 2012: 797410.
5. Engler AJ, Sen S, Sweeney HL, Discher DE, (2006) Matrix elasticity directs stem cell lineage specification. Cell 126: 677-689.
6. Huebsch N, Arany PR, Mao AS, Shvartsman D, Ali OA, et al. (2010) Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate. Nat Mater 9: 518-526.
7. Chowdhury F, Li Y, Poh YC, Yokohama-Tamaki T, Wang N, et al. (2010) Soft substrates promote homogeneous self-renewal of embryonic stem cells via downregulating cell-matrix tractions. PLoS One 5: e15655.
8. Schwartz MA, DeSimone DW, (2008) Cell adhesion receptors in mechanotransduction. Curr Opin Cell Biol 20: 551-556.
9. Alenghat FJ, Ingber DE, (2002) Mechanotransduction: all signals point to cytoskeleton, matrix, and integrins. Sci STKE 2002: pe6.
10. Schwartz MA, (2010) Integrins and extracellular matrix in mechanotransduction. Cold Spring Harb Perspect Biol 2: a005066.
11. Pollard TD, Blanchoin L, Mullins RD, (2000) Molecular mechanisms controlling actin filament dynamics in nonmuscle cells. Annu Rev Biophys Biomol Struct 29: 545-576.
12. Maruthamuthu V, Aratyn-Schaus Y, Gardel ML, (2010) Conserved F-actin dynamics and force transmission at cell adhesions. Curr Opin Cell Biol 22: 583-588.
13. Papusheva E, Heisenberg CP, (2010) Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis. EMBO J 29: 2753-2768.
14. Janmey PA, (1998) The cytoskeleton and cell signaling: component localization and mechanical coupling. Physiol Rev 78: 763-781.
15. Titushkin I, Cho M, (2007) Modulation of cellular mechanics during osteogenic differentiation of human mesenchymal stem cells. Biophys J 93: 3693-3702.
16. Erickson GR, Gimble JM, Franklin DM, Rice HE, Awad H, et al. (2002) Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vivo. Biochem Biophys Res Commun 290: 763-769.
17. Johnstone B, Hering TM, Caplan AI, Goldberg VM, Yoo JU, (1998) In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells. Exp Cell Res 238: 265-272.
18. McBeath R, Pirone DM, Nelson CM, Bhadriraju K, Chen CS, (2004) Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell 6: 483-495.
19. Vogel V, Sheetz MP, (2009) Cell fate regulation by coupling mechanical cycles to biochemical signaling pathways. Curr Opin Cell Biol 21: 38-46.
20. Wang N, Tytell JD, Ingber DE, (2009) Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus. Nat Rev Mol Cell Biol 10: 75-82.
21. Chen HC, Guan JL, (1994) Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase. Proc Natl Acad Sci U S A 91: 10148-10152.
22. Yan YX, Gong YW, Guo Y, Lv Q, Guo C, et al. (2012) Mechanical strain regulates osteoblast proliferation through integrin-mediated ERK activation. PLoS One 7: e35709.
23. Pommerenke H, Schreiber E, Durr F, Nebe B, Hahnel C, et al. (1996) Stimulation of integrin receptors using a magnetic drag force device induces an intracellular free calcium response. Eur J Cell Biol 70: 157-164.
24. Pommerenke H, Schmidt C, Durr F, Nebe B, Luthen F, et al. (2002) The mode of mechanical integrin stressing controls intracellular signaling in osteoblasts. J Bone Miner Res 17: 603-611.
25. Schmidt C, Pommerenke H, Durr F, Nebe B, Rychly J, (1998) Mechanical stressing of integrin receptors induces enhanced tyrosine phosphorylation of cytoskeletally anchored proteins. J Biol Chem 273: 5081-5085.
26. Higashida C, Kiuchi T, Akiba Y, Mizuno H, Maruoka M, et al. (2013) F- and G-actin homeostasis regulates mechanosensitive actin nucleation by formins. Nat Cell Biol 15: 395-405.
27. Horiuchi R, Akimoto T, Hong Z, Ushida T, (2012) Cyclic mechanical strain maintains Nanog expression through PI3K/Akt signaling in mouse embryonic stem cells. Exp Cell Res 318: 1726-1732.
28. Kawamura S, Miyamoto S, Brown JH, (2003) Initiation and transduction of stretch-induced RhoA and Rac1 activation through caveolae: cytoskeletal regulation of ERK translocation. J Biol Chem 278: 31111-31117.
29. Pearson G, Robinson F, Beers Gibson T, Xu BE, Karandikar M, et al. (2001) Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions. Endocr Rev 22: 153-183.
30. Kustermans G, Piette J, Legrand-Poels S, (2008) Actin-targeting natural compounds as tools to study the role of actin cytoskeleton in signal transduction. Biochem Pharmacol 76: 1310-1322.
31. Spector I, Braet F, Shochet NR, Bubb MR, (1999) New anti-actin drugs in the study of the organization and function of the actin cytoskeleton. Microsc Res Tech 47: 18-37.
32. Yarmola EG, Somasundaram T, Boring TA, Spector I, Bubb MR, (2000) Actin-latrunculin A structure and function. Differential modulation of actin-binding protein function by latrunculin A. J Biol Chem 275: 28120-28127.
33. Higashida C, Miyoshi T, Fujita A, Oceguera-Yanez F, Monypenny J, et al. (2004) Actin polymerization-driven molecular movement of mDia1 in living cells. Science 303: 2007-2010.
34. Yarmola EG, Klimenko ES, Fujita G, Bubb MR, (2007) Thymosin beta4: actin regulation and more. Ann N Y Acad Sci 1112: 76-85.
35. Bubb MR, Senderowicz AM, Sausville EA, Duncan KL, Korn ED, (1994) Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin. J Biol Chem 269: 14869-14871.
36. Tseng PC, Young TH, Wang TM, Peng HW, Hou SM, et al. (2012) Spontaneous osteogenesis of MSCs cultured on 3D microcarriers through alteration of cytoskeletal tension. Biomaterials 33: 556-564.
37. Zhang X, Cui X, Cheng L, Guan X, Li H, et al. (2012) Actin stabilization by jasplakinolide affects the function of bone marrow-derived late endothelial progenitor cells. PLoS One 7: e50899.
38. Engel E, Martinez E, Mills CA, Funes M, Planell JA, et al. (2009) Mesenchymal stem cell differentiation on microstructured poly (methyl methacrylate) substrates. Ann Anat 191: 136-144.
39. Feng T, Szabo E, Dziak E, Opas M, (2010) Cytoskeletal disassembly and cell rounding promotes adipogenesis from ES cells. Stem Cell Rev 6: 74-85.
40. Bost F, Aouadi M, Caron L, Binetruy B, (2005) The role of MAPKs in adipocyte differentiation and obesity. Biochimie 87: 51-56.