An Estrogen Receptor Dependent Mechanism of Oroxylin A in the Repression of Inflammatory Response

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Wang, Hong ^a   Guo, Ying ^a   Zhao, Xin ^a   Li, Huiying ^a   Fan, Guanwei ^a   Mao, Haoping ^a   Miao, Lin ^a   Gao, Xiumei ^a  

^a TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; CYTOKINE; ESTROGEN RECEPTOR; FLAVONOID; HERBACEOUS AGENT; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NITRIC OXIDE; OROXYLIN A; PHYTOESTROGEN; TUMOR NECROSIS FACTOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; DOWN REGULATION; GENE EXPRESSION; HERB; HUMAN; INFLAMMATION; MACROPHAGE; MOLECULAR MECHANICS; SCUTELLARIA BAICALENSIS;

ANIMALS; CELL LINE; CELL LINE, TUMOR; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FLAVONOIDS; HELA CELLS; HUMANS; INFLAMMATION; MACROPHAGES; MICE; NITRIC OXIDE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84880816361     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0069555     Document Type: Article

References (33)

1. Hu, (1996) National regulatory authority for Chinese medicinal drugs (Chinese). Shanghai: Shanghai Science and Technology.
2. Hu Y, Yang Y, You QD, Liu W, Gu HY, et al. (2006) Oroxylin A induced apoptosis of human hepatocellular carcinoma cell line HepG2 was involved in its antitumor activity. Biochem Biophys Res Commun 351: 521-527. doi:10.1016/j.bbrc.2006.10.064. PubMed: 17069758.
3. Mu R, Qi Q, Gu H, Wang J, Yang Y, et al. (2009) Involvement of p53 in oroxylin A-induced apoptosis in cancer cells. Mol Carcinog 48: 1159-1169. doi:10.1002/mc.20570. PubMed: 19626645.
4. Suresh Babu K, Hari Babu T, Srinivas PV, Sastry BS, Hara Kishore K, et al. (2005) Synthesis and in vitro study of novel 7-O-acyl derivatives of Oroxylin A as antibacterial agents. Bioorg Med Chem Lett 15: 3953-3956. doi:10.1016/j.bmcl.2005.05.045. PubMed: 16046127.
5. Lee S, Kim DH, Lee DH, Jeon SJ, Lee CH, et al. (2010) Oroxylin A, a flavonoid, stimulates adult neurogenesis in the hippocampal dentate gyrus region of mice. Neurochem Res 35: 1725-1732. doi:10.1007/s11064-010-0235-y. PubMed: 20680459.
6. Wanda GJ, Njamen D, Yankep E, Fotsing MT, Fomum ZT, et al. (2006) Estrogenic properties of isoflavones derived from Millettia griffoniana. Phytomedicine 13: 139-145. doi:10.1016/j.phymed.2005.06.003. PubMed: 16428019.
7. Zhang G, Qin L, Shi Y, (2007) Epimedium-derived phytoestrogen flavonoids exert beneficial effect on preventing bone loss in late postmenopausal women: a 24-month randomized, double-blind and placebo-controlled trial. J Bone Miner Res 22: 1072-1079. doi:10.1359/jbmr.070405. PubMed: 17419678.
8. Wilkinson AP, Wähälä K, Williamson G, (2002) Identification and quantification of polyphenol phytoestrogens in foods and human biological fluids. J Chromatogr B Anal Technol Biomed Life Sci 777: 93-109. doi:10.1016/S1570-0232(02)00095-8. PubMed: 12270203.
9. Xin D, Wang H, Yang J, Su YF, Fan GW, et al. (2010) Phytoestrogens from Psoralea corylifolia reveal estrogen receptor-subtype selectivity. Phytomedicine 17: 126-131. doi:10.1016/j.phymed.2009.05.015. PubMed: 19577453.
10. Wang Hong, Li Ming-Cong, Yang Jing, Yang Dan, Yan-Fang Suet al. (2011) Estrogenic properties of six compounds derived from Eucommia ulmoides Oliv. and their differing biological activity through estrogen receptors a and b. Food Chemistry 129: 408-416.
11. Kuiper GG, Gustafsson JA, (1997) The novel estrogen receptor-beta subtype: potential role in the cell- and promoter-specific actions of estrogens and anti-estrogens. FEBS Lett 410: 87-90. doi:10.1016/S0014-5793(97)00413-4. PubMed: 9247129.
12. Kuiper GG, Carlsson B, Grandien K, Enmark E, Häggblad J, et al. (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology 138: 863-870. doi:10.1210/en.138.3.863. PubMed: 9048584.
13. Cutolo M, Sulli A, Seriolo B, Accardo S, Masi AT, (1995) Estrogens, the immune response and autoimmunity. Clin Exp Rheumatol 13: 217-226. PubMed: 7656468.
14. Vegeto E, Pollio G, Pellicciari C, Maggi A, (1999) Estrogen and progesterone induction of survival of monoblastoid cells undergoing TNF-alpha-induced apoptosis. FASEB J 13: 793-803. PubMed: 10224223.
15. Grip O, Janciauskiene S, Lindgren S, (2003) Macrophages in inflammatory bowel disease. Curr Drug Targets Inflamm Allergy 2: 155-160. doi:10.2174/1568010033484179. PubMed: 14561168.
16. Kim SS, Oh OJ, Min HY, Park EJ, Kim Y, et al. (2003) Eugenol suppresses cyclooxygenase-2 expression in lipopolysaccharide-stimulated mouse macrophage RAW264.7 cells. Life Sci 73: 337-348. doi:10.1016/S0024-3205(03)00288-1. PubMed: 12757841.
17. Barrios-Rodiles M, Tiraloche G, Chadee K, (1999) Lipopolysaccharide modulates cyclooxygenase-2 transcriptionally and posttranscriptionally in human macrophages independently from endogenous IL-1 beta and TNF-alpha. J Immunol 163: 963-969. PubMed: 10395693.
18. Han HS, Qiao Y, Karabiyikoglu M, Giffard RG, Yenari MA, (2002) Influence of mild hypothermia on inducible nitric oxide synthase expression and reactive nitrogen production in experimental stroke and inflammation. J Neurosci 22: 3921-3928. PubMed: 12019311.
19. Duval DL, Miller DR, Collier J, Billings RE, (1996) Characterization of hepatic nitric oxide synthase: identification as the cytokine-inducible form primarily regulated by oxidants. Mol Pharmacol 50: 277-284. PubMed: 8700134.
20. Willoughby DA, Moore AR, Colville-Nash PR, (2000) COX-1, COX-2, and COX-3 and the future treatment of chronic inflammatory disease. Lancet 355: 646-648. doi:10.1016/S0140-6736(99)12031-2. PubMed: 10696997.
21. Krakauer T, (2004) Molecular therapeutic targets in inflammation: cyclooxygenase and NF-kappaB. Curr Drug Targets Inflamm Allergy 3: 317-324. doi:10.2174/1568010043343714. PubMed: 15379601.
22. Hayashi T, Yamada K, Esaki T, Muto E, Chaudhuri G, et al. (1998) Physiological concentrations of 17beta-estradiol inhibit the synthesis of nitric oxide synthase in macrophages via a receptor-mediated system. J Cardiovasc Pharmacol 31: 292-298. doi:10.1097/00005344-199802000-00016. PubMed: 9475272.
23. Zancan V, Santagati S, Bolego C, Vegeto E, Maggi A, et al. (1999) 17beta-estradiol decreases nitric oxide synthase II synthesis in vascular smooth muscle cells. Endocrinology 140: 2004-2009. doi:10.1210/en.140.5.2004. PubMed: 10218948.
24. Cuzzocrea S, Santagati S, Sautebin L, Mazzon E, Calabrò G, et al. (2000) 17beta-estradiol antiinflammatory activity in carrageenan-induced pleurisy. Endocrinology 141: 1455-1463. doi:10.1210/en.141.4.1455. PubMed: 10746650.
25. Saito S, Aras RS, Lou H, Ramwell PW, Foegh ML, (1999) Effects of estrogen on nitric oxide synthase expression in rat aorta allograft and smooth muscle cells. J Heart Lung Transplant 18: 937-945. doi:10.1016/S1053-2498(99)00060-1. PubMed: 10561103.
26. Cuzzocrea S, Mazzon E, Sautebin L, Serraino I, Dugo L, et al. (2001) The protective role of endogenous estrogens in carrageenan-induced lung injury in the rat. Mol Med 7: 478-487. PubMed: 11683373.
27. Mendelsohn ME, Karas RH, (1999) The protective effects of estrogen on the cardiovascular system. N Engl J Med 340: 1801-1811. doi:10.1056/NEJM199906103402306. PubMed: 10362825.
28. Wang J, Mazza G, (2002) Inhibitory effects of anthocyanins and other phenolic compounds on nitric oxide production in LPS/IFN-gamma-activated RAW. p. 264.7 macrophages. J Agric Food Chem 50: 850-857.
29. Kim HK, Cheon BS, Kim YH, Kim SY, Kim HP, (1999) Effects of naturally occurring flavonoids on nitric oxide production in the macrophage cell line RAW 264.7 and their structure-activity relationships. Biochem Pharmacol 58: 759-765. doi:10.1016/S0006-2952(99)00160-4. PubMed: 10449184.
30. Kim AR, Cho JY, Zou Y, Choi JS, Chung HY, (2005) Flavonoids differentially modulate nitric oxide production pathways in lipopolysaccharide-activated RAW264.7 cells. Arch Pharm Res 28: 297-304. doi:10.1007/BF02977796. PubMed: 15832817.
31. Raso GM, Meli R, Di Carlo G, Pacilio M, Di Carlo R, (2001) Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids in macrophage J774A.1. Life Sci 68: 921-931. doi:10.1016/S0024-3205(00)00999-1. PubMed: 11213362.
32. Xie QW, Kashiwabara Y, Nathan C, (1994) Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J Biol Chem 269: 4705-4708. PubMed: 7508926.
33. Faulds MH, Pettersson K, Gustafsson JA, Haldosén LA, (2001) Cross-talk between ERs and signal transducer and activator of transcription 5 is E2 dependent and involves two functionally separate mechanisms. Mol Endocrinol 15: 1929-1940. doi:10.1210/me.15.11.1929. PubMed: 11682624.