Riluzole does not affect hippocampal synaptic plasticity and spatial memory, which are impaired by diazepam in rats

Journal of Pharmacological Sciences

Volumn 122, Issue 3, 2013, Pages 232-236

  Sasaki Hamada, Sachie ^a   Sacai, Hiroaki ^a   Sugiyama, Azusa ^a,b   Iijima, Takahiro ^a   Saitoh, Akiyoshi ^b   Inagaki, Masatoshi ^b   Yamada, Mitsuhiko ^b   Oka, Jun Ichiro ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

Author keywords

Amnesia; Mood and anxiety disorder; Riluzole

Indexed keywords

DIAZEPAM; RILUZOLE;

AMNESIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DOSE COMPARISON; HIPPOCAMPUS; LONG TERM DEPRESSION; LONG TERM POTENTIATION; MALE; MAZE TEST; MEMORY DISORDER; NERVE CELL PLASTICITY; NEUROTOXICITY; NONHUMAN; RAT; SPATIAL MEMORY; TRANQUILIZING ACTIVITY;

AMNESIA; ANIMALS; ANTI-ANXIETY AGENTS; DIAZEPAM; HIPPOCAMPUS; MALE; MEMORY; MEMORY DISORDERS; NEURONAL PLASTICITY; NEUROPROTECTIVE AGENTS; RATS; RATS, WISTAR; RILUZOLE; SYNAPSES;

EID: 84880816332     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.13052SC     Document Type: Article

References (15)

1. Doble A. The pharmacology and mechanism of action of riluzole. Neurology. 1996;47:233-241.
2. Benoit E, Escande D. Riluzole specifically blocks inactivated Na channels in myelinated nerve fibre. Pflugers Arch. 1991; 419:603-609.
3. Mantz J, Laudenbach V, Lecharny JB, Henzel D, Desmonts JM. Riluzole, a novel antiglutamate, blocks GABA uptake by striatal synaptosomes. Eur J Pharmacol. 1994;257:7-8.
4. Huang CS, Song JH, Nagata K, Yeh JZ, Narahashi T. Effects of the neuroprotective agent riluzole on the high voltage-activated calcium channels of rat dorsal root ganglion neurons. J Pharmacol Exp Ther. 1997;282:1280-1290.
5. Pittenger C, Coric V, Banasr M, Bloch M, Krystal JH, Sanacora G. Riluzole in the treatment of mood and anxiety disorders. CNS Drugs. 2008;22:761-786.
6. Sugiyama A, Saitoh A, Iwai T, Takahashi K, Yamada M, Sasaki-Hamada S, et al. Riluzole produces distinct anxiolytic-like effects in rats without the adverse effects associated with benzodiaze-pines. Neuropharmacology. 2012;62:2489-2498.
7. Takahashi K, Murasawa H, Yamaguchi K, Yamada M, Nakatani A, Yoshida M, et al. Riluzole rapidly attenuates hyperemotional responses in olfactory bulbectomized rats, an animal model of depression. Behav Brain Res. 2011;216:46-52.
8. Haefely WE. Pharmacology of the benzodiazepine receptor. Eur Arch Psychiatry Neurol Sci. 1989;238:294-301.
9. Del Cerro S, Jung M, Lynch G. Benzodiazepines block long-term potentiation in slices of hippocampus and piriform cortex. Neuroscience. 1992;49:1-6.
10. Higashima M, Kinoshita H, Koshino Y. Differences in the effects of zolpidem and diazepam on recurrent inhibition and long-term potentiation in rat hippocampal slices. Neurosci Lett. 1998;245: 77-80.
11. Le Liboux A, Lefebvre P, Le Roux Y, Truffinet P, Aubeneau M, Kirkesseli S, et al. Single- and multiple-dose pharmacokinetics of riluzole in white subjects. J Clin Pharmacol. 1997;37:820-827.
12. Martin D, Thompson MA, Nadler JV. The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1. Eur J Pharmacol. 1993;250:473-476.
13. Rammes G, Zieglgänsberger W, Parsons CG. The fraction of activated N-methyl-D-aspartate receptors during synaptic transmission remains constant in the presence of the glutamate release inhibitor riluzole. J Neural Transm. 2008;115:1119-1126.
14. Morris RG, Davis S, Butcher SP. Hippocampal synaptic plasticity and NMDA receptors: a role in information storage? Philos Trans R Soc Lond B Biol Sci. 1990;329:187-204.
15. A a5 subunit-containing receptors. Psychopharmaco-logy. 2009;202:207-223.