Genetic Selection for Context-Dependent Stochastic Phenotypes: Sp1 and TATA Mutations Increase Phenotypic Noise in HIV-1 Gene Expression

PLoS Computational Biology

Volumn 9, Issue 7, 2013, Pages

  Miller Jensen, Kathryn ^a,b   Skupsky, Ron ^b,f   Shah, Priya S ^b   Arkin, Adam P ^b,c,d   Schaffer, David V ^b,c,e  

^a Yale University   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c University of California at Berkeley   (United States)

^d LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f UNIVERSITY OF SOUTHERN MAINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; DISEASES; FEEDBACK; STOCHASTIC SYSTEMS; SWITCHING; TRANSCRIPTION; VIRUSES;

BASAL EXPRESSION; CONTEXT DEPENDENT; GENE EXPRESSION LEVELS; GENES EXPRESSION; GENETIC SELECTION; GENOMICS; HUMAN IMMUNODEFICIENCY VIRUS-1; PROMOTER SEQUENCES; STOCHASTICS; SWITCHING FRACTIONS;

GENOME;

PREGNANCY SPECIFIC BETA1 GLYCOPROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TATA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; GENE AMPLIFICATION; GENE EXPRESSION; GENE MUTATION; GENE SWITCHING; GENETIC SCREENING; GENETIC SELECTION; GENOMICS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IN VITRO STUDY; LONG TERMINAL REPEAT; NONHUMAN; PHENOTYPE; POSITIVE FEEDBACK; PROMOTER REGION; STATISTICS; TRANSACTIVATION; VIRAL GENETICS; VIRUS CELL INTERACTION; VIRUS GENE;

EID: 84880807208     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1003135     Document Type: Article

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