Antidiarrhoea and toxicological evaluation of the leaf extract of Dissotis rotundifolia triana (Melastomataceae)

BMC Complementary and Alternative Medicine

Volumn 10, Issue , 2010, Pages

  Abere, Tavs A ^a   Okoto, Pius E ^a   Agoreyo, Freddy O ^a  

^a UNIVERSITY OF BENIN   (Nigeria)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; CARDIAC GLYCOSIDE; CASTOR OIL; CHARCOAL; DISSOTIS ROTUNDIFOLIA EXTRACT; GENTAMICIN; PLANT EXTRACT; SAPONIN; SODIUM CHLORIDE; UNCLASSIFIED DRUG; ANTIDIARRHEAL AGENT; ANTIINFECTIVE AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; DIARRHEA; DISSOTIS ROTUNDIFOLIA; DOSE RESPONSE; EOSINOPHILIA; ESCHERICHIA COLI; FEMALE; GASTROINTESTINAL MOTILITY; HEART; KIDNEY PARENCHYMA; KIDNEY TUBULE NECROSIS; LD 50; LIVER PARENCHYMA; MALE; MELASTOMATACEAE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PHYTOCHEMISTRY; PLANT LEAF; PSEUDOMONAS AERUGINOSA; RAT; SALMONELLA TYPHI; STAPHYLOCOCCUS AUREUS; TESTIS; TOXICOLOGY; TREATMENT DURATION; WISTAR RAT; AFRICAN MEDICINE; ANIMAL; BACTERIUM; CELL NUCLEUS; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CYTOPLASM; DRUG EFFECT; EOSINOPHIL; KIDNEY; LIVER; METABOLISM; NECROSIS;

ALKALOIDS; ANIMALS; ANTI-BACTERIAL AGENTS; ANTIDIARRHEALS; BACTERIA; CARDIAC GLYCOSIDES; CASTOR OIL; CELL NUCLEUS; CYTOPLASM; DIARRHEA; DOSE-RESPONSE RELATIONSHIP, DRUG; EOSINOPHILIA; EOSINOPHILS; FEMALE; GASTROINTESTINAL MOTILITY; KIDNEY; LETHAL DOSE 50; LIVER; MALE; MEDICINE, AFRICAN TRADITIONAL; MELASTOMATACEAE; MICE; NECROSIS; PARASYMPATHOLYTICS; PLANT EXTRACTS; PLANT LEAVES; SAPONINS; TESTIS;

EID: 78249270748     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-10-71     Document Type: Article

References (27)

1. Srivastera J, Lambert J, Vietweyar N. Medicinal plants: An expanding role in development. World Bank Technical Paper 1996, 320(1).
2. Baurmman RH. Traditional Medicine in Modern Healthcare. World Health Forum 1982, 3(1).
3. Holistic Online. , http://www.holisticonline.com/
4. Eisenberg DM, Kester RC, Foster C, Norlock FE, Calkins DR, Delbanco TL. Unconventional medicine in the United States: prevalence, costs and patterns of use. N Engl J Med 1993, 328:246-52. 10.1056/NEJM199301283280406, 8418405.
5. Eisenberg DM, Davis RB, Ettner SC, Appel S, Wilkey S, VanRompay M, Kessler R. Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up survey. JAMA 1998, 280:1569-75. 10.1001/jama.280.18.1569, 9820257.
6. Sofowora A. The state of medicinal plants research in Nigeria. 1986, 101. Ibadan University press, Nigeria, 1.
7. Loigier HA. Spermatophyta. Descriptive flora of Puerto Rico and Adjacent Islands 1994, 1:3.
8. Wagner WL, Herbst DR, Sohmer SH. Manual of the flowering plants of Hawaii. 1990, 210. University of Hawaii press, Bishop Museum, Honolulu.
9. Gill LS. Ethnomedical uses of plants in Nigeria. 1992, 103. University of Benin press.
10. Botanical description of Dissotis rotundifolia. , http://hear.Org/pier/species/Dissotis-rotundifolia.asp
11. Kokwaso JC. Medicinal plants of East Africa. 1976, 198. General printers, Nairobi, Kenya.
12. Noumi E, Yomi A. Medicinal plants used in intestinal diseases in Mbalmayo Region. Fitoterapia 2001, 246-254. 10.1016/S0367-326X(00)00288-4, 11295300.
13. Watt JM, Breyer-Brandwijk MG. The medicinal and poisonous plants of Southern and Eastern Africa. 1962, 137:744. E & S Livingstone Ltd, Edinburgh & London, 2.
14. Brain KR, Turner TD. Practical evaluation of Phytopharmaceuticals. 1975, 144. Wright-Scientechnica, Bristol, 1.
15. Ciulei I. Methodology for analysis of vegetable drugs. UNIDO Romania 1981, 17-25.
16. Harborne JB. Phytochemical methods. A guide to modern technique of plant analysis. 1992, 279. Chapman and Hill, London.
17. Evans WC. Trease and Evans Pharmacognosy. 1996, 119-159. WB Saunders Ltd. London, 14.
18. Onwukaeme ND, Anuforo DC. Phytochemical and Pharmacological studies on Pycanthus angolensis (Welb) Warb (Myristicaceae). Discovery and Innovation 1993, 5:317-322.
19. Izzo AA, Nicoleti M, Giannatassio B, Capasso F. Antidiarrhoeal activity of Terminalia sevicea Burch. Ex. Dc. Extracts. Natural Drugs and the Digestive tract EMSI, Rome 1992, 223-230. Capasso F, Mascolo N.
20. Washington JA. In manual of clinical microbiology. 1985, 967-970. American Society of Microbiology, Washinggton DC, Lennette E, Balowa A, Hausler WJ, Shadomy HJ.
21. Dietrich L. A new approach to practical acute toxicity testing. Archives of Toxicology 1983, 54:275-287. 10.1007/BF01234480, 6667118.
22. Adefemi OA, Elujoba AA, Odesanmi WO. Evaluation of the toxicity potential of Cassia podocarpa with reference to official Senna. West Afr Journal of Pharmacol and Drug Res 1988, 8:41-48.
23. Obasi NB, Igboechi AC, Anuforo DC. Studies of the antidiarrhoeal potentials of some compositae plants. Medicinal plants in a developing economy. Proceedings of a workshop organized by the Nigerian Society of Nigeria 1990, 108-116.
24. Abere TA, Agoreyo FO. Antimicrobial and toxicological evaluation of the leaves of Baissea axillaries Hua used in the management of HIV/AIDS patients. BMC Complement Altern Med 2006, 6:22. 10.1186/1472-6882-6-22, 1513602, 16790064.
25. Klein R. Toxicology and herbs. Aust Journal of Med Herbalism 1996, 8:100-110.
26. Akubue PI. Textbook of Pharmacology. 2006, 30-31. African First Publishers Limited, 1.
27. Malmfors T, Teiling A. LD 50: Its value for the pharmaceutical industry in safety evaluation of drugs. Acta Pharmacol Toxicol 1983, 52(Suppl 2):229.