Effects of pre-existing anti-carrier immunity and antigenic element multiplicity on efficacy of a modular virus-like particle vaccine

Biotechnology and Bioengineering

Volumn 110, Issue 9, 2013, Pages 2343-2351

  Chuan, Yap P ^a   Rivera Hernandez, Tania ^a   Wibowo, Nani ^a   Connors, Natalie K ^a   Wu, Yang ^a   Hughes, Fiona K ^a   Lua, Linda H L ^a   Middelberg, Anton P J ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Biomolecular engineering; Modular; Pre existing immunity; Vaccine; Virus like particle

Indexed keywords

ANTIGENIC PEPTIDES; BACTERICIDAL ACTIVITY; BIOMOLECULAR ENGINEERING; MODULAR; MODULARIZATIONS; PRE-EXISTING IMMUNITY; VACCINE DELIVERY; VIRUS-LIKE PARTICLES;

ANTIBODIES; ANTIGENS; MODULAR CONSTRUCTION; PEPTIDES; VACCINES; VIRUSES;

IMMUNE SYSTEM;

ANTIGEN; DRUG CARRIER; GROUP A STREPTOCOCCUS PEPTIDE ANTIGEN J8I; IMMUNOGLOBULIN G; UNCLASSIFIED DRUG; VIRUS LIKE PARTICLE VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ANTIBODY TITER; ARTICLE; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; DNA SEQUENCE; DRUG ANTIGENICITY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETIC ENGINEERING AND GENE TECHNOLOGY; IMMUNE RESPONSE; IMMUNITY; IMMUNOGENICITY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PURIFICATION; STREPTOCOCCUS GROUP A; VIRUS LIKE AGENT;

BIOMOLECULAR ENGINEERING; MODULAR; PRE-EXISTING IMMUNITY; VACCINE; VIRUS-LIKE PARTICLE;

ANIMALS; ANTIGENS; DRUG CARRIERS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; IMMUNOGLOBULIN G; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; PEPTIDES; POLYOMAVIRUS; VACCINES, VIRUS-LIKE PARTICLE;

MURINE POLYOMAVIRUS; STREPTOCOCCUS SP. 'GROUP A';

EID: 84880792243     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.24907     Document Type: Article

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