Mepivacaine-induced contraction involves phosphorylation of extracellular signal-regulated kinase through activation of the lipoxygenase pathway in isolated rat aortic smooth muscle

Canadian Journal of Physiology and Pharmacology

Volumn 91, Issue 4, 2013, Pages 285-294

  Lee, Hyo Min ^a   Ok, Seong Ho ^b   Sung, Hui Jin ^b   Eun, So Young ^b   Kim, Hye Jung ^b   Lee, Soo Hee ^b   Kang, Sebin ^b   Shin, Il Woo ^b   Lee, Heon Keun ^b   Chung, Young Kyun ^b   Choi, Mun Jeoung ^c   Bae, Sung Il ^d   Sohn, Ju Tae ^b  

^a Hallym University College of Medicine   (South Korea)

^b Gyeongsang National University School of Medicine   (South Korea)

^c Gyeongsang National University   (South Korea)

^d Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

Aa 861; Aorta; Cyclooxygenase; Extracellular signal regulated kinase; Lipoxygenase; Mepivacaine; Vasoconstriction

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; ARACHIDONATE 5 LIPOXYGENASE; ARACHIDONIC ACID; CYCLOOXYGENASE 2; DOCEBENONE; FLUCONAZOLE; INDOMETACIN; MEPACRINE; MEPIVACAINE; MITOGEN ACTIVATED PROTEIN KINASE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NORDIHYDROGUAIARETIC ACID; PHENIDONE; VERAPAMIL;

ANIMAL CELL; ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; ARTERY CONSTRICTION; ARTERY ENDOTHELIUM; ARTERY MUSCLE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; MALE; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SMOOTH MUSCLE FIBER; SMOOTH MUSCLE TONE; THORACIC AORTA; UPREGULATION; WESTERN BLOTTING;

ANIMALS; AORTA, THORACIC; ARACHIDONATE 5-LIPOXYGENASE; ARACHIDONIC ACID; CELLS, CULTURED; CYCLOOXYGENASE 2; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; MALE; MEPIVACAINE; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; UP-REGULATION;

EID: 84880792185     PISSN: 00084212     EISSN: 12057541     Source Type: Journal    
DOI: 10.1139/cjpp-2012-0197     Document Type: Article

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