The Pathological Phenotypes of Human TDP-43 Transgenic Mouse Models Are Independent of Downregulation of Mouse Tdp-43

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Xu, Ya Fei ^a   Prudencio, Mercedes ^a   Hubbard, Jaime M ^a   Tong, Jimei ^a   Whitelaw, Ena C ^a   Jansen West, Karen ^a   Stetler, Caroline ^a   Cao, Xiangkun ^a   Song, John ^a   Zhang, Yong Jie ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROPEPTIDE; PROTEIN ANTIBODY; SORTILIN; TAR DNA BINDING PROTEIN; THREONYLALANYLGLUTAMYLGLUTAMYLLEUCYLGLUTAMINYLGLUTAMINYLPHENYLALANYLPHENYLALANYLCYSTYLGLUTAMINYLTYROSYLGLYCYLGLUTAMYLVALYLVALYLASPARTYLVALYLPHENYLALANINE; TRANSLIN; UNCLASSIFIED DRUG; VIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN LEVEL; BRAIN NERVE CELL; CELL COUNT; CELL FUNCTION; CELL STRUCTURE; CELL SURVIVAL; CONTROLLED STUDY; DENDRITIC SPINE; GENE DISRUPTION; GENE TARGETING; HOMOZYGOTE; HUMAN; IN VIVO STUDY; LOSS OF FUNCTION MUTATION; NEUROMUSCULAR SYNAPSE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PROTEIN BLOOD LEVEL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METABOLISM; REGULATORY MECHANISM; RNA ANALYSIS; RNA METABOLISM; RNA SPLICING; SPLICING DEFECT; TRANSGENIC MOUSE; UPREGULATION;

ALTERNATIVE SPLICING; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ANIMALS, NEWBORN; DENDRITIC SPINES; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; DOWN-REGULATION; FRONTOTEMPORAL LOBAR DEGENERATION; HEMIZYGOTE; HOMOZYGOTE; HUMANS; INJECTIONS, INTRAVENTRICULAR; MICE; MICE, TRANSGENIC; PHENOTYPE; RNA, MESSENGER; SYNAPSES;

EID: 84880783961     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0069864     Document Type: Article

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