Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction

Acta Neuropathologica

Volumn 123, Issue 6, 2012, Pages 807-823

  Cannon, Ashley ^a   Yang, Baoli ^b   Knight, Joshua ^a,c   Farnham, Ian M ^a   Zhang, Yongjie ^a   Wuertzer, Charles A ^a   D'Alton, Simon ^a,c   Lin, Wen Lang ^a   Castanedes Casey, Monica ^a   Rousseau, Linda ^a   Scott, Brittany ^a   Jurasic, Michael ^a   Howard, John ^a,c   Yu, Xin ^a   Bailey, Rachel ^a,c   Sarkisian, Matthew R ^c   Dickson, Dennis W ^a   Petrucelli, Leonard ^a   Lewis, Jada ^a,c  

^a MAYO GRADUATE SCHOOL   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Amyotrophic lateral sclerosis; Apoptosis; Frontotemporal lobar degeneration; Neurodevelopment; TDP 43; Transgenic mice

Indexed keywords

CASPASE 3; COMPLEMENTARY DNA; TAR DNA BINDING PROTEIN;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ASTROCYTOSIS; BRAIN ATROPHY; BRAIN WEIGHT; CELL LOSS; CERVICAL SPINAL CORD; CONTROLLED STUDY; DOWN REGULATION; FOREBRAIN; FRONTOTEMPORAL DEMENTIA; HISTOPATHOLOGY; IMMUNOREACTIVITY; LONG TERM POTENTIATION; MOUSE; NERVE CELL; NERVE DEGENERATION; NEUROPATHOLOGY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; TDP 43 PROTEINOPATHY; UBIQUITINATION;

ANIMALS; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; MICE; MICE, 129 STRAIN; MICE, TRANSGENIC; MITOCHONDRIA; NEURONS; TDP-43 PROTEINOPATHIES; TIME FACTORS; UBIQUITIN;

EID: 84866423602     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-012-0979-3     Document Type: Article

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