A Comparison of Aggregatibacter actinomycetemcomitans (Aa) Virulence Traits in a Rat Model for Periodontal Disease

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Schreiner, Helen ^a   Li, Yu ^a   Cline, Joshua ^b   Tsiagbe, Vincent K ^a,b,c   Fine, Daniel H ^a,b  

^a RUTGERS SCHOOL OF DENTAL MEDICINE   (United States)

^b The State University of New Jersey   (United States)

^c RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLETHAL DISTENDING TOXIN; LEUKOTOXIN;

AGGREGATIBACTER ACTINOMYCETEMCOMITANS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL COUNT; BACTERIAL STRAIN; BACTERIAL VIRULENCE; CD4+ T LYMPHOCYTE; CELL VIABILITY; COLONY FORMING UNIT M; CONTROLLED STUDY; IMMUNOMODULATION; IMMUNOREGULATION; LYMPHOCYTE PROLIFERATION; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOLYSIS; PERIODONTAL DISEASE; RAT;

AGGREGATIBACTER ACTINOMYCETEMCOMITANS; ANIMALS; BACTERIAL TOXINS; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; COLONY COUNT, MICROBIAL; DISEASE MODELS, ANIMAL; EXOTOXINS; MALE; MUTATION; PASTEURELLACEAE INFECTIONS; PERIODONTAL DISEASES; RATS; RATS, SPRAGUE-DAWLEY; VIRULENCE;

EID: 84880732318     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0069382     Document Type: Article

References (38)

1. Zambon JJ, (1985) Actinobacillus actinomycetemcomitans in human periodontal disease. J Clin Periodontol 12: 1-20.
2. Yaun A, Yang P-C, Lee L-N, Chang D-V, Kuo S-H, et al. (1992) Actinobacillus actinomycetemcomitans pneumonia with chest wall involvement and rib destruction. Chest 101: 1450-1452.
3. Anolik R, Berkowitz RJ, Campos JM, Friedman AD, (1981) Actinobacillus endocarditis associated with periodontal disease. Clin Pediatr (Phila) 20: 653-655.
4. Townsend T, Gillenwater J, (1969) Urinary tract infection due to Actinobacillus actinomycetemcomitans. JAMA 210: 558.
5. Martin BF, Derby BM, Budzilovich GN, Ransohoff J, (1967) Brain Abcess due to Actinobacillus actinomycetemcomitans. Neurology 17: 833-837.
6. Fine DH, Kaplan JB, Kachlany SC, Schreiner HC, (2006) How we got attached to Actinobacillus actinomycetemcomitans: a model for infectious diseases. Periodontol 2000 42: 114-157.
7. Fives-Taylor PM, Meyer D, Minz K, (1995) Characteristics of Actinobacillus actinomycetemcomitans invasion and adhesion to cultured epithelial cells. Adv Dental Res 9: 55-62.
8. Damek-Poprawa M, Haris M, Volgina A, Korostoff J, DiRienzo JM, (2011) Cytolethal distending toxin damages the oral epithelium of gingival explants. J Dent Res 90: 874-879.
9. Ohara M, Miyauchi M, Tsuruda K, Takata T, Sugai M, (2011) Topical application of Aggregatibacter actinomycetemcomitans cytolethal distending toxin induces cell cycle arrest in the rat gingival epithelium in vivo. J Periodontal Res 46: 389-395.
10. Rabin SD, Flitton JG, Demuth DR, (2009) Aggregatibacter actinomycetemcomitans cytolethal distending toxin induces apoptosis in nonproliferating macrophages by a phosphatase-independent mechanism. Infect Immun 77: 3161-3169.
11. Belibasakis GN, Johansson A, Wang Y, Chen C, Kalfas S, et al. (2005) The cytolethal distending toxin induces receptor activator of NF-kappaB ligand expression in human gingival fibroblasts and periodontal ligament cells. Infect Immun 73: 342-351.
12. Belibasakis GN, Brage M, Lagergard T, Johansson A, (2008) Cytolethal distending toxin upregulates RANKL expression in Jurkat T-cells. APMIS 116: 499-506.
13. Hsu H, Lacey DL, Dunstan CR, Solovyev I, Colombero A, et al. (1999) Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. P Natl Acad Sci U S A 96: 3540-3545.
14. Lally ET, Golub EE, Kieba IR, Taichman NS, Rosenbloom J, et al. (1989) Analysis of the Actinobacillus actinomycetemcomitans Leukotoxin gene. J Biol Chem 264: 15451-15456.
15. Welch R, Bauer M, Kent A, Leeds J, Moayeri M, et al. (1995) Battling against host phagocytes: the wherefore of the RTX family of toxins? Infect Agents Dis 4: 254-272.
16. Welch RA, (1991) Pore-forming cytolysins of gram-negative bacteria. Mol Microbiol 5: 521-528.
17. Felmlee T, Pellett S, Welch RA, (1985) Nucleotide sequence of an Escherichia coli chromosomal hemolysin. J Bacteriol 163: 94-105.
18. Kraig E, Dailey T, Kolodrubetz D, (1990) Nucleotide sequence of the Leukotoxin Gene from Actinobacillus actinomycetemcomitans: homology to the alpha-hemolysin/leukotoxin gene family. Infect Immun 58: 920-929.
19. Dileepan T, Kachlany SC, Balashova NV, Patel J, Maheswaran SK, (2007) Human CD18 is the functional receptor for Aggregatibacter actinomycetemcomitans leukotoxin. Infect Immun 75: 4851-4856.
20. Taichman NS, Dean RT, Sanderson CJ, (1980) Biochemical and morphological characterization of the killing of human monocytes by a leukotoxin derived from Actinobacillus actinomycetemcomitans. Infect Immun 28: 258-268.
21. Taichman NS, Simpson DL, Sakurada S, Cranfield M, DiRienzo J, et al. (1987) Comparative studies on the biology of Actinobacillus actinomycetemcomitans leukotoxin in primates. Oral Microbiol Immunol 2: 97-104.
22. Li Y, Messina C, Bendaoud M, Fine D, Schreiner H, et al. (2010) Adaptive immune response in osteoclastic bone resportion induced by orally administered Aggregatibacter actinomycetemcomitans in a rat model of periodontal disease. Oral Microbiol Immun 25: 275-292.
23. Shenker BJ, Besack D, McKay T, Pankoski L, Zekavat A, et al. (2005) Induction of cell cycle arrest in lymphocytes by Actinobacillus actinomycetemcomitans cytolethal distending toxin requires three subunits for maximum activity. J Immunol 174: 2228-2234.
24. Sugai M, Kawamoto T, Peres SY, Ueno Y, Komatsuzawa H, et al. (1998) The Cell Cycle-Specific Growth-Inhibitory Factor Produced by Actinobacillus actinomycetemcomitans Is a Cytolethal Distending Toxin. Infect Immun 66: 5008-5019.
25. Kachlany SC, Fine DH, Figurski DH, (2000) Secretion of RTX leukotoxin by Actinobacillus actinomycetemcomitans. Infection & Immunity 68: 6094-6100.
26. Fine DH, Schreiner H, Nasri-Heir C, Greenberg B, Jiang S, et al. (2009) An improved cost-effective, reproducible method for evaluation of bone loss in a rodent model. J Clin Periodontol 36: 106-113.
27. Schreiner H, Sinatra K, Kaplan J, Furgang D, Kachlany S, et al. (2003) Tight-adherence genes of Actinobacillus actinomycetemcomitans are required for virulence in a rat model. P Natl Acad Sci USA 100: 7295-7300.
28. Thomson VJ, Bhattacharjee MK, Fine DH, Derbyshire KM, Figurski DH, (1999) Direct selection of IS903 transposon insertions by use of a broad-host-range vector: isolation of catalase-deficient mutants of Actinobacillus actinomycetemcomitans. J Bacteriol 181: 7298-7307.
29. Bhattacharjee MK, Fine DH, Figurski DH, (2007) tfoX (sxy)-dependent transformation of Aggregatibacter (Actinobacillus) actinomycetemcomitans. Gene 399: 53-64.
30. Balashova NV, Crosby JA, Al Ghofaily L, Kachlany SC, (2006) Leukotoxin confers beta-hemolytic activity to Actinobacillus actinomycetemcomitans. Infect Immun 74: 2015-2021.
31. DiFranco K, Kaswala R, Patel C, Kasinathan C, Kachlany S (2013) Leukotoxin (Leukothera ®;LtxA) kills rodent white blood cells by targeting leukocyte function associated antigen-1(LFA-1). Comparative Med 63: In press.
32. Graves DT, Fine D, Teng YT, Van Dyke TE, Hajishengallis G, (2008) The use of rodent models to investigate host-bacteria interactions related to periodontal diseases. Journal of Clinical Periodontology 35: 89-105.
33. Jinadasa RN, Bloom SE, Weiss RS, Duhamel GE (2011) Cytolethal distending toxin: a conserved bacterial genotoxin that blocks cell cycle progression, leading to apoptosis of a broad range of mammalian cell lineages. Microbiology July: 1851-1875.
34. Shenker BJ, McKay T, Datar S, Miller M, Chowhan R, et al. (1999) Actinobacillus actinomycetemcomitans immunosuppressive protein is a member of the family of cytolethal distending toxins capable of causing a G2 arrest in human T cells. J Immunol 162: 4773-4780.
35. Yoshie H, Taubman MA, Olson CL, Ebersole JL, Smith DJ, (1987) Periodontal bone loss and immune characteristics after adoptive transfer of Actinobacillus-sensitized T cells to rats. Journal of Periodontal Research 22: 499-505.
36. Taubman MA, Valverde P, Han,X Kawai, (2005) T (2005) Immune Response: The Key to bone Resorption in Periodontal Disease. J Periodontol 76: 2033-2041.
37. Moore WE, Holdeman LV, Cato EP, Smibert RM, Burmeister JA, et al. (1985) Comparative bacteriology of juvenile periodontitis. Infect Immun 48: 507-519.
38. Kaplan J, Schreiner H, Furgang D, Fine DH, (2002) Population and genetic diversity of Actinobacilus actinomycetemcomitans strains isolated from localized juvenile periodontitis patients. J Clin Microbiol 40: 1181-1187.