An improved cost-effective, reproducible method for evaluation of bone loss in a rodent model

Journal of Clinical Periodontology

Volumn 36, Issue 2, 2009, Pages 106-113

  Fine, Daniel H ^a   Schreiner, Helen ^a   Nasri Heir, Cibele ^a   Greenberg, Barbara ^a   Jiang, Shuying ^a   Markowitz, Kenneth ^a   Furgang, David ^a  

^a UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

Author keywords

A. actinomycetemcomitans; Animal model; Bone loss analysis; Periodontal disease; Rodent

Indexed keywords

BACTERIUM ANTIBODY; EXOTOXIN; LEUKOTOXIN; VIRULENCE FACTOR;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; ANIMAL; ARTICLE; BLOOD; DISEASE MODEL; ECONOMICS; EVALUATION; GENETICS; MALE; MEDICAL PHOTOGRAPHY; METHODOLOGY; MICROBIOLOGY; MOUTH DISEASE; MUTAGENESIS; OSTEOLYSIS; PERIODONTITIS; RADIOGRAPHY; RAT; REPRODUCIBILITY; SPRAGUE DAWLEY RAT;

ACTINOBACILLUS ACTINOMYCETEMCOMITANS; AGGRESSIVE PERIODONTITIS; ALVEOLAR BONE LOSS; ANIMALS; ANTIBODIES, BACTERIAL; DIAGNOSIS, ORAL; DISEASE MODELS, ANIMAL; EXOTOXINS; MALE; MUTAGENESIS; PHOTOGRAPHY, DENTAL; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; VIRULENCE FACTORS;

EID: 58849164947     PISSN: 03036979     EISSN: 1600051X     Source Type: Journal    
DOI: 10.1111/j.1600-051X.2008.01353.x     Document Type: Article

References (16)

1. Balashova, N. V., Crosby, J. A., Al Ghofaily, L. Kachlany, S. C. (2006) Leukotoxin confers bets-hemolytic activity to Actinobacillus actinomycetemcomitans. Infection and Immunity 74, 2015 2021.
2. Bhattacharjee, M. K., Fine, D. H. Figurski, D. H. (2007) tfoX (sxy)-dependent transformation of Aggregatibacter (Actinobacillus) actinomycetemcomitans. Gene 399, 53 64.
3. Chang, K. M., Ramamurthy, N., McNamara, T., Evans, R., Klausen, B., Murray, P. Golub, L. (1994) Tetracyclines inhibit Porphyromonas gingivalis-induced alveolar bone loss in rats by a non-antimicrbial mechanism. Journal of Periodontal Research 29, 242 249.
4. Crawford, J. M., Taubman, M. A. Smith, D. J. (1978) The natuaral history of periodontal bone loss in germfree and gnotobiotic rats infected with periodontopathic microrgansims. Journal of Periodontal Research 13, 316 325.
5. Fiehn, N., Klausen, B. Evans, R. (1992) Periodontal bone loss in Porphyromonas gingivalis-infected specific pathogen-free rats after preinoculation with endogenous Streptococcus sanguis. Journal of Periodontal Research 27, 609 614.
6. Fine, D. H., Furgang, D., Schreiner, H. C., Goncharoff, P., Charlesworth, J., Ghazwan, G., Fitzgerald-Bocarsly, P. Figurski, D. H. (1999) Phenotypic variation in Actinobacillus actinomycetemcomitans during laboratory growth: implcations for virulence. Microbiology 145, 1335 1347.
7. Garant, P. Cho, M. I. (1979) Histopathogenesis of spontaneous perodontol disease in conventional rats. Journal of Periodontal Research 14, 297 309.
8. Goodson, J. M. (1986) Clinical measurements of periodontitis. Journal of Clinical Periodontology 13, 446 460.
9. Goodson, J. M., Haffajee, A. D. Socransky, S. S. (1984) The relationship between attachment level loss and alveolar bone loss. Journal of Clinical Periodontology 11, 348 359.
10. Graves, D. T., Fine, D., Teng, Y-T., Van Dyke, T. E. Hajishengallis, G. (2007) The use of rodent to investigate host-bacteria interactions re;ated to periodontal diseases. Journal of Clinical Periodontology 35, 89 105.
11. Klausen, B. (1991) Microbiological and immunological aspects of experimental periodontal disease in rats: a review article. Journal of Periodontology 62, 59 73.
12. Klausen, B., Evans, R. T., Ramamurethy, N., Gollub, L. M., Sfintescu, C., Lee, J.- Y., Bedi, G., Zambon, J. Genco, R. (1991) Periodontal bone level and a gingival proteinase activity in gnotobiotic rats immunized with Bacteroides gingivalis. Oral Microbiology and Immunology 6, 193 201.
13. Klausen, B., Evans, R. T. Sfintescu, C. (1989) Two complementary methods of assessing periodontal bone level in rats. Scandinavian Journal of Dental Research 97, 494 499.
14. Schreiner, H. C., Sinatra, K., Kaplan, J. B., Furgang, D., Kachlany, S. C., Planet, P. J., Perez, B. A., Figurski, D. H. Fine, D. H. (2003) Tight-adherence genes of Actinobacillus actinomycetecomitans are required for virulence in a rat model. Proceedings of the National Academy of Science USA 100, 7295 7300.
15. Taubman, M., Genco, R. Hillman, J. (1989) The specific pathogen-free human: a new frontier in oral infectious disease research. Advances in Dental Research 3, 58 68.
16. Wilensky, A., Gabet, Y., Yumoto, H., Houri-Haddad, Y. Shapira, L. (2005) Three-dimensional quantification of alveolar bone loss in Porphyromonas gingivalis-infected mice using micro-computed tomography. Journal of Periodontology 76, 1282 1286.