Characterization of chemically defined poly-N-isopropylacrylamide based copolymeric adjuvants

Vaccine

Volumn 31, Issue 35, 2013, Pages 3519-3527

  Shakya, Akhilesh Kumar ^a,b   Holmdahl, Rikard ^b   Nandakumar, Kutty Selva ^b   Kumar, Ashok ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY KANPUR   (India)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Collagen induced arthritis; PAAm; PNiPAAm; PNiPAAm co VPBA; PNiPAAm co VPBA co DMAEMA; Poly N isopropylallylamine; Polybut 3 en 2 one

Indexed keywords

ACRYLIC ACID DERIVATIVE; AMIDE; AMINE; BORONIC ACID DERIVATIVE; COLLAGEN ANTIBODY; COLLAGEN TYPE 2; COPOLYMER; FREE RADICAL; FRUCTOSE; IMMUNOGLOBULIN G; KETONE; LIGAND; POLY(N ISOPROPYLACRYLAMIDE); POLYMER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; BINDING AFFINITY; BIOCOMPATIBILITY; CELL INFILTRATION; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CONTROLLED STUDY; FEMALE; HYDROPHILICITY; HYDROPHOBICITY; IMMUNOCOMPETENT CELL; IN VITRO STUDY; IN VIVO STUDY; INJECTION SITE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADICAL REACTION; RAT; RODENT; SYNTHESIS; T LYMPHOCYTE ACTIVATION;

COLLAGEN INDUCED ARTHRITIS; PAAM; PNIPAAM; PNIPAAM-CO-VPBA; PNIPAAM-CO-VPBA-CO-DMAEMA; POLY-N-ISOPROPYLALLYLAMINE; POLYBUT-3-EN-2-ONE;

ACRYLIC RESINS; ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES; ANTIBODY FORMATION; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, RHEUMATOID; BIOCOMPATIBLE MATERIALS; BORONIC ACIDS; COLLAGEN; FEMALE; FRUCTOSE; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; IMMUNOGLOBULIN G; LYMPHOCYTE ACTIVATION; MALE; MICE; MICE, TRANSGENIC; RATS; T-LYMPHOCYTES;

EID: 84880728446     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2013.05.084     Document Type: Article

References (34)

1. Firestein G.S. Evolving concepts of rheumatoid arthritis. Nature 2003, 423:356-361.
2. Monach P.A., Benoist C., Mathis D. The role of antibodies in mouse models of rheumatoid arthritis, and relevance to human disease. Adv Immunol 2004, 82:217-248.
3. Kannan K., Ortmann R.A., Kimpel D. Animal models of rheumatoid arthritis and their relevance to human disease. Pathophysiology 2004, 12:167-181.
4. Edelman R. The development and use of vaccine adjuvants. Mol Biotechnol 2002, 21:129-148.
5. Reed S.G., Bertholet S., Coler R.N., Friede M. Newhorizons in adjuvants for vaccine development. Trends Immunol 2009, 30:23-32.
6. Wilson-Welder J.H., Torres M.P., Kipper M.J., Mallapragada S.K., Wannemuehler M.J., Narasimhan B. Vaccine adjuvants: current challenges and future approaches. J Pharm Sci 2009, 98:1278-1316.
7. Holmdahl R., Andersson M.E., Goldschmidt T.J., Jansson L., Karlsson M., Malmström V., et al. Collagen induced arthritis as an experimental model for rheumatoid arthritis. APMIS 1989, 97:575-584.
8. Nandakumar K.S., Bajtner E., Hill L., Böhm B., Rowley M.J., Burkhardt H., et al. Arthritogenic antibodies specific for a major type II collagen triple-helical epitope bind and destabilize cartilage independent of inflammation. Arthritis Rheum 2008, 58:184-196.
9. Galaev I.Y., Mattiasson B. 'Smart' polymers and what they could do in biotechnology and medicine. Trends Biotechnol 1999, 17:335-340.
10. Jeong B., Gutowska A. Lessons from nature: stimuli-responsive polymers and their biomedical applications. Trends Biotechnol 2002, 20:305-311.
11. Cooperstein M.A., Canavan H.E. Biological cell detachment from poly(N-isopropyl acrylamide) and its applications. Langmuir 2010, 26:7695-7707.
12. Kumar A., Srivastava A., Galaev I.Y., Mattiasson B. Smart polymers: physical forms and bioengineering applications. Prog Polym Sci 2007, 32:1205-1237.
13. Shakya A.K., Kumar A., Nandakumar K.S. Adjuvant properties of a biocompatible thermo-responsive polymer of N-isopropylacrylamide in autoimmunity and arthritis. J R Soc Interface 2011, 8:1748-1759.
14. Shakya A.K., Kumar A., Klaczkowska D., Hultqvist M., Hagenow K., Holmdahl R., et al. Collagen type II and a thermo-responsive polymer of N-isopropylacrylamide induce arthritis independent of Toll-like receptors: a strong influence by major histocompatibility complex class II and Ncf1 genes. Am J Pathol 2011, 179:2490-2500.
15. Elmas B., Senel S., Tuncel A. A new thermosensitive fluorescent probe for diol sensing: poly(N-isopropylacrylamide-co-vinylphenylboronic acid)-alizarin red S complex. React Funct polym 2007, 67:87-96.
16. Kumar A., Reddy R.M. Monosaccharide based phase transformable gels at normal pH 2010, IN-800868.
17. Dzhambazov B., Holmdahl M., Yamada H., Lu S., Vestberg M., Holm B., et al. The major T cell epitope on type II collagen is glycosylated in normal cartilage but modified by arthritis in both rats and humans. Eur J Immunol 2005, 35:357-366.
18. Michaëlsson E., Malmström V., Reis S., Engström A., Burkhardt H., Holmdahl R. T cell recognition of carbohydrates on type II collagen. J Exp Med 1994, 180:745-749.
19. Bäcklund J., Treschow A., Bockermann R., Holm B., Holm L., Issazadeh-Navikas S., et al. Glycosylation of type II collagen is of major importance for T cell tolerance and pathology in collagen-induced arthritis. Eur J Immunol 2002, 32:3776-3784.
20. Hultqvist M., Olofsson P., Holmberg J., Backström B.T., Tordsson J., Holmdahl R. Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene. Proc Natl Acad Sci USA 2004, 101:12646-12651.
21. Grab B., Miles A.J., Furcht L.T., Fields G.B. Promotion of fibroblast adhesion by triple-helical peptide models of type I collagen-derived sequences. J Biol Chem 1996, 271:12234-12240.
22. Mo J.A., Bona C.A., Holmdahl R. Variable region gene selection of immunoglobulin G-expressing B cells with specificity for a defined epitope on type II collagen. Eur J Immunol 1993, 23:2503-2510.
23. Uysal H., Bockermann R., Nandakumar K.S., Sehnert B., Bajtner E., Engström A., et al. Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis. J Exp Med 2009, 206:449-462.
24. Kumar A., Kamihira M., Galaev I.Y., Mattiasson B., Iijima S. Type-specific separation of animal cells in aqueous two-phase systems using antibody conjugates with temperature-sensitive polymers. Biotechnol Bioeng 2001, 75:570-580.
25. Shakya A.K., Sharma P., Kumar A. Synthesis and characterization of thermo-responsive poly(N-isopropylacrylamide)-bovine liver catalase bioconjugate. Enzyme Microb Technol 2010, 47:277-282.
26. Smith P.K., Krohn R.I., Hermanson G.T., Mallia A.K., Gartner F.H., Provenzano M.D., et al. Measurement of protein using bicinchoninic acid. Anal Biochem 1985, 150:76-85.
27. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983, 65:55-63.
28. Srivastava A., Shakya A.K., Kumar A. Boronate affinity chromatography of cells and biomacromolecules using cryogel matrices. Enzyme Microb Technol 2012, 51:373-381.
29. Holmdahl R., Rubin K., Klareskog L., Larsson E., Wigzell H. Characterization of the antibody response in mice with type II collagen-induced arthritis, using monoclonal anti-type II collagen antibodies. Arthritis Rheum 1986, 29:400-410.
30. Holmdahl R., Carlsen S., Mikulowska A., Vestberg M., Brunsberg U., Hansson A.S., et al. Genetic analysis of murine models for rheumatoid arthritis. Human genome methods 1998, 215-238. CRC Press, New York. K.W. Adolpho (Ed.).
31. Svensson L., Jirholt J., Holmdahl R., Jansson L. B cell-deficient mice do not develop type II collagen induced arthritis (CIA). Clin Exp Immunol 1998, 111:521-526.
32. Bajtner E., Nandakumar K.S., Engström A., Holmdahl R. Chronic development of collagen-induced arthritis is associated with arthritogenic antibodies against specific epitopes on type II collagen. Arthritis Res Ther 2005, 7:R1148-R1157.
33. Ivanov A.E., Galaev I.Y., Mattiasson B. Interaction of sugars, polysaccharides and cells with boronate-containing copolymers: from solution to polymer brushes. J Mol Recognit 2006, 19:322-331.
34. Ferreira S.A., Gama F.M., Vilanova M. Polymeric nanogels as vaccine delivery systems. Nanomed: Nanotechnol Biol Med 2012, 9:159-173.