PASylation: A biological alternative to PEGylation for extending the plasma half-life of pharmaceutically active proteins

Protein Engineering, Design and Selection

Volumn 26, Issue 8, 2013, Pages 489-501

  Schlapschy, Martin ^a   Binder, Uli ^b   Börger, Claudia ^a   Theobald, Ina ^a   Wachinger, Klaus ^a   Kisling, Sigrid ^a   Haller, Dirk ^a   Skerra, Arne ^a,b  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b XL Protein GmbH   (Germany)

Author keywords

biologic; dosing; kidney filtration; pharmacokinetics; therapeutic protein

Indexed keywords

BIOLOGIC; BIOLOGICAL POLYMERS; BIOPHARMACEUTICAL PROTEINS; BIOPHYSICAL PROPERTIES; DOSING; HYDRODYNAMIC VOLUMES; POLYPEPTIDE CHAIN; THERAPEUTIC PROTEIN;

BIOPOLYMERS; ESCHERICHIA COLI; ETHYLENE GLYCOL; PHARMACOKINETICS; POLYPEPTIDES;

INTERFERONS;

AMINO ACID DERIVATIVE; HUMAN GROWTH HORMONE; HYBRID PROTEIN; IMMUNOGLOBULIN F(AB) FRAGMENT; MACROGOL; POLYPEPTIDE; PROLYL ALANYL SERINE; SOMATOMEDIN C; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG CONJUGATION; ESCHERICHIA COLI; FEMALE; GENE CASSETTE; GENE SYNTHESIS; GLOMERULUS FILTRATION; HYDRODYNAMICS; HYDROPHILICITY; IMMUNOGENICITY; IN VITRO STUDY; KIDNEY CLEARANCE; MOUSE; NONHUMAN; PASYLATION; PLASMA HALF LIFE; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN MODIFICATION; PROTEIN PURIFICATION; PROTEIN SECONDARY STRUCTURE; PROTEIN SYNTHESIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

BIOLOGIC; DOSING; KIDNEY FILTRATION; PHARMACOKINETICS; THERAPEUTIC PROTEIN;

ALANINE; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; ESCHERICHIA COLI; GROWTH HORMONE; HALF-LIFE; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; POLYETHYLENE GLYCOLS; PROLINE; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT FUSION PROTEINS; SERINE;

EID: 84880724831     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzt023     Document Type: Article

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