Calreticulin and cancer

Pathology and Oncology Research

Volumn 19, Issue 2, 2013, Pages 149-154

  Zamanian, Mohammadreza ^a,b   Veerakumarasivam, Abhi ^a,c   Abdullah, Syahril ^a   Rosli, Rozita ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

^b ROYAN INSTITUTE FOR REPRODUCTIVE BIOMEDICINE   (Iran)

^c PERDANA UNIVERSITY   (Malaysia)

Author keywords

Calreticulin; Cancer; Endoplasmic reticulum; Invasion; Malignant progression; Metastasis

Indexed keywords

BINDING PROTEIN; CALCIUM; CALRETICULIN; CORTICAL ACTIN BINDING PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR ALPHA; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; PROTEIN KINASE B; THROMBOSPONDIN 1; TRANSCRIPTION FACTOR SLUG; UNCLASSIFIED DRUG; UVOMORULIN; VASCULOTROPIN;

CALCIUM HOMEOSTASIS; CALRETICULIN GENE; CANCER GROWTH; CANCER RISK; CARCINOGENESIS; CELL ADHESION; CELL DEATH; CELL MOTILITY; DISEASE ASSOCIATION; GENE OVEREXPRESSION; HUMAN; IMMUNOGENICITY; INTRACELLULAR SIGNALING; MALIGNANT NEOPLASTIC DISEASE; METASTASIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; TRANSCRIPTION REGULATION; TUMOR INVASION;

CALRETICULIN; CARCINOGENESIS; ENDOPLASMIC RETICULUM; HUMANS; NEOPLASMS;

EID: 84880703965     PISSN: 12194956     EISSN: 15322807     Source Type: Journal    
DOI: 10.1007/s12253-012-9600-2     Document Type: Review

References (79)

1. Michalak M et al (1999) Calreticulin: one protein, one gene, many functions. Biochem J 344(2):281-292
2. Goicoechea S et al (2002) The anti-adhesive activity of thrombospondin is mediated by the N-terminal domain of cell surface calreticulin. J Biol Chem 277(40):37219-37228
3. Michalak M et al (1992) Calreticulin. Biochem J 285(3):681-692
4. Michalak M, Robert Parker JM, Opas M (2002) Ca2+ signaling and calcium binding chaperones of the endoplasmic reticulum. Cell Calcium 32(5-6):269-278
5. Rojiani MV et al (1991) In vitro interaction of a polypeptide homologous to human Ro/SS-A antigen (calreticulin) with a highly conserved amino acid sequence in the cytoplasmic domain of integrin alpha subunits. Biochemistry 30:9859-9866
6. Burns K et al (1994) Modulation of gene expression by calreticulin binding to the glucocorticoid receptor. Nature 367(6462):476-480
7. Gelebart P, Opas M, Michalak M (2005) Calreticulin, a Ca2+-binding chaperone of the endoplasmic reticulum. Int J Biochem Cell Biol 37(2):260-266
8. Qiu Y, Michalak M (2009) Transcriptional control of the calreticulin gene in health and disease. Int J Biochem Cell Biol 41(3):531-538
9. Gold LI et al (2010) Calreticulin: non-endoplasmic reticulum functions in physiology and disease. FASEB J 24(3):665-683
10. Nanney LB et al (2008) Calreticulin enhances porcine wound repair by diverse biological effects. Am J Pathol 173(3):610-630
11. Gu VY et al (2008) Calreticulin in human pregnancy and pre-eclampsia. Mol Hum Reprod 14(5):309-315
12. Pagh R et al (2008) The chaperone and potential mannan-binding lectin (MBL) co-receptor calreticulin interacts with MBL through the binding site for MBL-associated serine proteases. FEBS J 275(3):515-526
13. Yokoyama M, Hirata K-I (2005) New function of calreticulin: calreticulin-dependent mRNA destabilization. Circ Res 97(10):961-963
14. McCauliffe DP et al (1992) The 5'-flanking region of the human calreticulin gene shares homology with the human GRP78, GRP94, and protein disulfide isomerase promoters. J Biol Chem 267(4):2557-2562
15. Waser M et al (1997) Regulation of calreticulin gene expression by calcium. J Cell Biol 138(3):547-557
16. Nguyen TQ, Donald Capra J, Sontheimer RD (1996) Calreticulin is transcriptionally upregulated by heat shock, calcium and heavy metals. Mol Immunol 33(4-5):379-386
17. Michalak M et al (2009) Calreticulin, a multi-process calcium-buffering chaperone of the endoplasmic reticulum. Biochem J 417(3):651-666
18. Qiu Y et al (2008) Regulation of the calreticulin gene by GATA6 and Evi-1 transcription factorsâ€. Biochemistry 47(12):3697-3704
19. Guo L et al (2001) COUP-TF1 antagonizes Nkx2.5-mediated activation of the calreticulin gene during cardiac development. J Biol Chem 276:2797-2801
20. Lynch J et al (2005) Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca2+-dependent signaling cascade. J Cell Biol 170:37-47
21. Vig S et al (2012) C/EBPα mediates the transcriptional suppression of human calreticulin gene expression by TNFα. Int J Cell Biol 44(1):113-122
22. Opas M et al (1991) Regulation of expression and intracellular distribution of calreticulin, a major calcium binding protein of nonmuscle cells. J Cell Physiol 149(1):160-171
23. Yoon G-S et al (2000) Nuclear matrix of calreticulin in hepatocellular carcinoma. Cancer Res 60(4):1117-1120
24. Gold LI, et al. (2006) Overview of the role for calreticulin in the enhancement of wound healing through multiple biological effects. The journal of investigative dermatology. Symposium proceedings/the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research 11(1):57-65
25. Huang J-B et al (2004) Identification of channels promoting calcium spikes and waves in HT1080 tumor cells. Cancer Res 64(7):2482-2489
26. Pallero MA et al (2008) Thrombospondin 1 binding to calreticulin-LRP1 signals resistance to anoikis. FASEB J 22(11):3968-3979
27. Kageyama K et al (2002) Overexpression of calreticulin modulates protein kinase B/Akt signaling to promote apoptosis during cardiac differentiation of cardiomyoblast H9c2 cells. J Biol Chem 277(22):19255-19264
28. Okunaga T et al (2006) Calreticulin, a molecular chaperone in the endoplasmic reticulum, modulates radiosensitivity of human glioblastoma U251MG cells. Cancer Res 66(17):8662-8671
29. Lim S, et al. (2008) Enhanced calreticulin expression promotes calcium-dependent apoptosis in postnatal cardiomyocytes. 25:390-396
30. Bini L et al (1997) Protein expression profiles in human breast ductal carcinoma and histologically normal tissue. Electrophoresis 18(15):2832-2841
31. Chahed K et al (2005) Expression of fibrinogen E-fragment and fibrin E-fragment is inhibited in the human infiltrating ductal carcinoma of the breast: the two-dimensional electrophoresis and MALDI-TOF-mass spectrometry analyses. Int J Oncol 27(5):1425-1431
32. Kageyama S et al (2004) Identification by proteomic analysis of calreticulin as a marker for bladder cancer and evaluation of the diagnostic accuracy of its detection in urine. Clin Chem 50(5):857-866
33. Ayodele A et al (2000) Polypeptide expression in prostate hyperplasia and prostate adenocarcinoma. Anal Cell Pathol 21(1):1-9
34. Kim Y et al (2004) Glucoronic acid is a novel inducer of heat shock response. Mol Cell Biochem 259(1):23-33
35. Hong S-H et al (2004) An autoantibody-mediated immune response to calreticulin isoforms in pancreatic cancer. Cancer Res 64(15):5504-5510
36. Du X-L et al (2007) Proteomic profiling of proteins dysregulted in Chinese esophageal squamous cell carcinoma. J Mol Med 85(8):863-875
37. Nishimori T et al (2006) Proteomic analysis of primary esophageal squamous cell carcinoma reveals downregulation of a cell adhesion protein, periplakin. Proteomics 6(3):1011-1018
38. Chen CN et al (2009) Association between color doppler vascularity index, angiogenesis-related molecules, and clinical outcomes in gastric cancer. J Surg Oncol 99(7):402-408
39. Vougas K et al (2008) Two-dimensional electrophoresis and immunohistochemical study of calreticulin in colorectal adenocarcinoma and mirror biopsies. J Blacan Union Oncol 13(1):101-107
40. White TK, Zhu Q, Tanzer ML (1995) Cell surface calreticulin is a putative mannoside lectin which triggers mouse melanoma cell spreading. J Biol Chem 270(27):15926-15929
41. Dissemond J et al (2004) Differential downregulation of endoplasmic reticulum-residing chaperones calnexin and calreticulin in human metastatic melanoma. Cancer Lett 203(2):225-231
42. Helbling D et al (2005) CBFB-SMMHC is correlated with increased calreticulin expression and suppresses the granulocytic differentiation factor CEBPA in AML with inv(16). Blood 106(4):1369-1375
43. Chen CN et al (2009) Identification of calreticulin as a prognosis marker and angiogenic regulator in human gastric cancer. Ann Surg Oncol 16(2):524-533
44. Lwin Z-M, et al. (2010) Clinicopathological significance of calreticulin in breast invasive ductal carcinoma. Mod Pathol
45. Eric A et al (2009) Effects of humoral immunity and calreticulin overexpression on postoperative course in breast cancer. Pathol Oncol Res 15(1):89-90
46. Pabst T et al (2001) AML1-ETO downregulates the granulocytic differentiation factor C/EBP[alpha] in t(8;21) myeloid leukemia. Nat Med 7(4):444-451
47. Lu Y-C et al (2011) Changes in tumor growth and metastatic capacities of j82 human bladder cancer cells suppressed by down-regulation of calreticulin expression. Am J Pathol 179:1425-1433
48. Hayashi E et al (2005) Proteomic profiling for cancer progression: differential display analysis for the expression of intracellular proteins between regressive and progressive cancer cell lines. Proteomics 5(4):1024-1032
49. Zhu J (1996) Ultraviolet B irradiation and cytomegalovirus infection synergize to induce the cell surface expression of 52-kD/Ro antigen. Clin Exp Immunol 1(103):47-53
50. Alur M et al (2009) Suppressive roles of calreticulin in prostate cancer growth and metastasis. Am J Pathol 175(2):882-890
51. Porcellini S et al (2006) Regulation of peripheral T cell activation by calreticulin. J Exp Med 203(2):461-471
52. Dupuis M et al (1993) The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes. J Exp Med 177(1):1-7
53. Andrin C et al (1998) Interaction between a Ca2+-binding protein calreticulin and perforin, a component of the cytotoxic T-cell granules†. Biochemistry 37(29):10386-10394
54. Sipione S et al (2005) Impaired cytolytic activity in calreticulin-deficient CTLs. J Immunol 174(6):3212-3219
55. Obeid M et al (2007) Ecto-calreticulin in immunogenic chemotherapy. Immunol Rev 220:22-34
56. Obeid M et al (2007) Leveraging the immune system during chemotherapy: moving calreticulin to the cell surface converts apoptotic death from "silent" to immunogenic. Cancer Res 67(17):7941-7944
57. Clarke C, Smyth MJ (2007) Calreticulin exposure increases cancer immunogenicity. Nat Biotechnol 25(2):192-193
58. Zhou P et al (2008) Calreticulin expression in the clonal plasma cells of patients with systemic light-chain (AL-) amyloidosis is associated with response to high-dose melphalan. Blood 111(2):549-557
59. Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100(1):57-70
60. Hayashida Y et al (2006) Calreticulin represses E-cadherin gene expression in Madin-Darby Canine kidney cells via slug. J Biol Chem 281(43):32469-32484
61. Fresno Vara JA et al (2004) PI3K/Akt signalling pathway and cancer. Cancer Treat Rev 30(2):193-204
62. Xu Q et al (2005) Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways. Oncogene 24(36):5552-5560
63. Yu H, Pardoll D, Jove R (2009) STATs in cancer inflammation and immunity: a leading role for STAT3. Nat Rev Cancer 9(11):798-809
64. Luo M-L et al (2006) Amplification and overexpression of CTTN (EMS1) contribute to the metastasis of esophageal squamous cell carcinoma by promoting cell migration and anoikis resistance. Cancer Res 66(24):11690-11699
65. Weaver AM (2008) Cortactin in tumor invasiveness. Cancer Lett 265(2):157-166
66. Du XL et al (2009) Calreticulin promotes cell motility and enhances resistance to anoikis through STAT3-CTTN-Akt pathway in esophageal squamous cell carcinoma. Oncogene 28(42):3714-3722
67. Dedhar S et al (1994) Inhibition of nuclear hormone receptor activity by calreticulin. Nature 367(6462):480-483
68. Green S et al (1988) The N-terminal DNA-binding 'zinc finger' of the oestrogen and glucocorticoid receptors determines target gene specificity. EMBO J 7(10):3037-3044
69. Platet N et al (2000) Unliganded and liganded estrogen receptors protect against cancer invasion via different mechanisms. Mol Endocrinol 14(7):999-1009
70. Lusche DF, Wessels D, Soll DR (2009) The effects of extracellular calcium on motility, pseudopod and uropod formation, chemotaxis, and the cortical localization of myosin II in Dictyostelium discoideum. Cell Motil Cytoskeleton 66(8):567-587
71. Fache S et al (2005) Calcium mobilization stimulates Dictyostelium discoideum shear-flow-induced cell motility. J Cell Sci 118(15):3445-3458
72. Chantome A et al (2009) KCa2.3 channel-dependent hyperpolarization increases melanoma cell motility. Exp Cell Res 315(20):3620-3630
73. Titushkin I, Cho M (2009) Regulation of cell cytoskeleton and membrane mechanics by electric field: role of linker proteins. Biophys J 96(2):717-728
74. Nakamura K et al (2001) Functional specialization of calreticulin domains. J Cell Biol 154(5):961-972
75. Mesaeli N et al (1999) Calreticulin is essential for cardiac development. J Cell Biol 144(5):857-868
76. Camacho P, Lechleiter JD (1995) Calreticulin inhibits repetitive intracellular Ca2+ waves. Cell 82(5):765-771
77. Arnaudeau S et al (2002) Calreticulin differentially modulates calcium uptake and release in the endoplasmic reticulum and mitochondria. J Biol Chem 277(48):46696-46705
78. Orr AW et al (2003) Thrombospondin signaling through the calreticulin/LDL receptor-related protein co-complex stimulates random and directed cell migration. J Cell Sci 116(14):2917-2927
79. Li SS, Forslöw A, Sundqvist K-G (2005) Autocrine regulation of T cell motility by calreticulin-thrombospondin-1 interaction. J Immunol 174(2):654-661