Acetylcholinesterase inhibition in the basolateral amygdala plays a key role in the induction of status epilepticus after soman exposure

NeuroToxicology

Volumn 38, Issue , 2013, Pages 84-90

  Prager, Eric M ^a   Aroniadou Anderjaska, Vassiliki ^a   Almeida Suhett, Camila P ^a   Figueiredo, Taiza H ^a   Apland, James P ^b   Braga, Maria F M ^a  

^a Uniformed Services University of the Health Sciences   (United States)

^b US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

Author keywords

Acetylcholinesterase; Basolateral amygdala; Hippocampus; Piriform cortex; Soman; Status epilepticus

Indexed keywords

ACETYLCHOLINESTERASE; SODIUM CHLORIDE; SOMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASOLATERAL AMYGDALA; BRAIN REGION; ENZYME ACTIVITY; EPILEPTIC STATE; EXPOSURE; HIPPOCAMPUS; MALE; NERVE CELL DEGENERATION; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PYRIFORM CORTEX; RAT;

ACETYLCHOLINESTERASE; BASOLATERAL AMYGDALA; HIPPOCAMPUS; PIRIFORM CORTEX; SOMAN; STATUS EPILEPTICUS;

AMYGDALA; ANIMALS; BRAIN; CHOLINESTERASE INHIBITORS; HIPPOCAMPUS; MALE; NERVE DEGENERATION; OLFACTORY PATHWAYS; RATS; SOMAN; STATUS EPILEPTICUS;

EID: 84880682822     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2013.06.006     Document Type: Article

References (37)

1. Apland J.P., Aroniadou-Anderjaska V., Braga M.F. Soman induces ictogenesis in the amygdala and interictal activity in the hippocampus that are blocked by a GluR5 kainate receptor antagonist in vitro. Neuroscience 2009, 159:380-389.
2. Apland J.P., Aroniadou-Anderjaska V., Figueiredo T.H., Green C.E., Swezey R.R., Yang C., et al. Efficacy of the GluK1/AMPA receptor antagonist LY293558 against seizures and neuropathology in a soman-exposure model without pretreatment and its pharmacokinetics after intramuscular administration. J Pharmacol Exp Ther 2012, 344:133-140.
3. Apland J.P., Figueiredo T.H., Qashu F., Aroniadou-Anderjaska V., Souza A.P., Braga M.F. Higher susceptibility of the ventral versus the dorsal hippocampus and the posteroventral versus anterodorsal amygdala to soman-induced neuropathology. Neurotoxicology 2010, 31:485-492.
4. Aroniadou-Anderjaska V., Figueiredo T.H., Apland J.P., Qashu F., Braga M.F. Primary brain targets of nerve agents: the role of the amygdala in comparison to the hippocampus. Neurotoxicology 2009, 30:772-776.
5. Aroniadou-Anderjaska V., Fritsch B., Qashu F., Braga M.F. Pathology and pathophysiology of the amygdala in epileptogenesis and epilepsy. Epilepsy Res 2008, 78:102-116.
6. Ben-Ari Y., Zigmond R.E., Shute C.C., Lewis P.R. Regional distribution of choline acetyltransferase and acetylcholinesterase within the amygdaloid complex and stria terminalis system. Brain Res 1977, 120:435-444.
7. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254.
8. Ellman G.L., Courtney K.D., Andres V., Feather-Stone R.M. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 1961, 7:88-95.
9. Figueiredo T.H., Aroniadou-Anderjaska V., Qashu F., Apland J.P., Pidoplichko V., Stevens D., et al. Neuroprotective efficacy of caramiphen against soman and mechanisms of its action. Br J Pharmacol 2011, 164:1495-1505.
10. Figueiredo T.H., Qashu F., Apland J.P., Aroniadou-Anderjaska V., Souza A.P., Braga M.F. The GluK1 (GluR5) Kainate/{alpha}-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist LY293558 reduces soman-induced seizures and neuropathology. J Pharmacol Exp Ther 2011, 336:303-312.
11. Gundersen H.J., Jensen E.B., Kieu K., Nielsen J. The efficiency of systematic sampling in stereology-reconsidered. J Microsc 1999, 193:199-211.
12. Hayward I.J., Wall H.G., Jaax N.K., Wade J.V., Marlow D.D., Nold J.B. Decreased brain pathology in organophosphate-exposed rhesus monkeys following benzodiazepine therapy. J Neurol Sci 1990, 98:99-106.
13. Kadar T., Cohen G., Sahar R., Alkalai D., Shapira S. Long-term study of brain lesions following soman, in comparison to DFP and metrazol poisoning. Hum Exp Toxicol 1992, 11:517-523.
14. Kristiansen S.L., Nyengaard J.R. Digital stereology in neuropathology. APMIS 2012, 120:327-340.
15. Lallement G., Carpentier P., Collet A., Pernot-Marino I., Baubichon D., Sentenac-Roumanou H., et al. Involvement of glutamatergic system of amygdala in generalized seizures induced by soman: comparison with the hippocampus. C R Acad Sci III 1991, 313:421-426.
16. Langston J.L., Wright L.K., Connis N., Lumley L.A. Characterizing the behavioral effects of nerve agent-induced seizure activity in rats: increased startle reactivity and perseverative behavior. Pharmacol Biochem Behav 2012, 100:382-391.
17. McDonald A.J., Mascagni F. Neuronal localization of m1 muscarinic receptor immunoreactivity in the rat basolateral amygdala. Brain Struct Funct 2010, 215:37-48.
18. McDonough J.H., McLeod C.G., Nipwoda M.T. Direct microinjection of soman or VX into the amygdala produces repetitive limbic convulsions and neuropathology. Brain Res 1987, 435:123-137.
19. McDonough J.H., Shih T.M. Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology. Neurosci Biobehav Rev 1997, 21:559-579.
20. McDonough J.H., Zoeffel L.D., McMonagle J., Copeland T.L., Smith C.D., Shih T.M. Anticonvulsant treatment of nerve agent seizures: anticholinergics versus diazepam in soman-intoxicated guinea pigs. Epilepsy Res 2000, 38:1-14.
21. Mesulam M.M., Hersh L.B., Mash D.C., Geula C. Differential cholinergic innervation within functional subdivisions of the human cerebral cortex: a choline acetyltransferase study. J Comp Neurol 1992, 318:316-328.
22. Mohapel P., Dufresne C., Kelly M.E., McIntyre D.C. Differential sensitivity of various temporal lobe structures in the rat to kindling and status epilepticus induction. Epilepsy Res 1996, 23:179-187.
23. Myhrer T. Neuronal structures involved in the induction and propagation of seizures caused by nerve agents: implications for medical treatment. Toxicology 2007, 239:1-14.
24. Padilla S., Lassiter T.L., Hunter D. Biochemical measurement of cholinesterase activity. Methods Mol Med 1999, 22:237-245.
25. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates 2005, Elsevier, New York, NY. 4th ed.
26. Petras J.M. Soman neurotoxicity. Fundam Appl Toxicol 1981, 1:242.
27. Prager E.M., Bergstrom H.C., Grunberg N.E., Johnson L.R. The importance of reporting housing and husbandry in rat research. Front Behav Neurosci 2011, 5:38.
28. Qashu F., Figueiredo T.H., Aroniadou-Anderjaska V., Apland J.P., Braga M.F. Diazepam administration after prolonged status epilepticus reduces neurodegeneration in the amygdala but not in the hippocampus during epileptogenesis. Amino Acids 2010, 38:189-197.
29. Racine R., Rose P.A., Burnham W.M. After discharge thresholds and kindling rates in dorsal and ventral hippocampus and dentate gyrus. Can J Neurol Sci 1977, 4:273-278.
30. Racine R.J. Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 1972, 32:281-294.
31. Rossetti F., de Araujo Furtado M., Pak T., Bailey K., Shields M., Chanda S., et al. Combined diazepam and HDAC inhibitor treatment protects against seizures and neuronal damage caused by soman exposure. Neurotoxicology 2012, 33:500-511.
32. Schmitz C., Hof P.R. Recommendations for straightforward and rigorous methods of counting neurons based on a computer simulation approach. J Chem Neuroanat 2000, 20:93-114.
33. Schmued L.C., Albertson C., Slikker W. Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration. Brain Res 1997, 751:37-46.
34. Shih T.M., Duniho S.M., McDonough J.H. Control of nerve agent-induced seizures is critical for neuroprotection and survival. Toxicol Appl Pharmacol 2003, 188:69-80.
35. Skovira J.W., McDonough J.H., Shih T.M. Protection against sarin-induced seizures in rats by direct brain microinjection of scopolamine, midazolam or MK-801. J Mol Neurosci 2010, 40:56-62.
36. White L.E., Price J.L. The functional anatomy of limbic status epilepticus in the rat. I. Patterns of 14C-2-deoxyglucose uptake and Fos immunocytochemistry. J Neurosci 1993, 13:4787-4809.
37. White L.E., Price J.L. The functional anatomy of limbic status epilepticus in the rat. II. The effects of focal deactivation. J Neurosci 1993, 13:4810-4830.