Attenuation of isoproterenol-induced cardiac fibrosis in transgenic rats harboring an angiotensin-(1-7)-producing fusion protein in the heart

Therapeutic Advances in Cardiovascular Disease

Volumn 4, Issue 2, 2010, Pages 83-96

  Ferreira, Anderson J ^a   Kitten, Gregory T ^a   Gava, Elisandra ^a   Castro, Carlos H ^a   Guatimosim, Silvia ^a   Almeida, Pedro W m ^a   Gomes, Enéas R m ^a   Dias Peixoto, Marco Fabrício ^a   Alves, Márcia N m ^a   Fagundes Moura, Cristiane R ^a   Almeida, Alvair P ^a   Guimarães, Alexandre M ^a   Santos, Robson A s ^a   Reudelhuber, Timothy ^c   Bader, Michael ^b  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

Author keywords

Angiotensin; Fibrosis; Heart; MHC; Renin angiotensin system; Transgenic rats

Indexed keywords

ANGIOTENSIN[1-7]; CALCIUM ION; COLLAGEN TYPE 3; FIBRONECTIN; ISOPRENALINE; MYOSIN HEAVY CHAIN ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE MEASUREMENT; CALCIUM SIGNALING; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SCREENING; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; HEART FUNCTION; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART RATE; HETEROZYGOTE; HOMOZYGOTE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; REPERFUSION; RIBONUCLEASE PROTECTION ASSAY; TELEMETRY; TRANSGENIC RAT;

ANGIOTENSIN I; ANIMALS; ARRHYTHMIAS, CARDIAC; BLOOD PRESSURE; CALCIUM; DISEASE MODELS, ANIMAL; FIBROSIS; GENE EXPRESSION REGULATION; HEART RATE; HEART VENTRICLES; ISOPROTERENOL; MALE; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; MYOSIN HEAVY CHAINS; PEPTIDE FRAGMENTS; PROMOTER REGIONS, GENETIC; RATS; RATS, SPRAGUE-DAWLEY; RATS, TRANSGENIC; TELEMETRY;

EID: 77950497363     PISSN: 17539447     EISSN: None     Source Type: Journal    
DOI: 10.1177/1753944709353426     Document Type: Article

References (33)

1. Bader, M. ( 2002) Role of the local renin-angiotensin system in cardiac damage: a minireview focussing on transgenic animal models. J Mol Cell Cardiol 34: 1455-1462.
2. Benter, I.F., Yousif, M.H., Anim, J.T., Cojocel, C. and Diz, D.I. ( 2006) Angiotensin-(1-7) prevents development of severe hypertension and end-organ damage in spontaneously hypertensive rats treated with L-name. Am J Physiol Heart Circ Physiol 290: H684-H691
3. Botelho, L.M., Block, C.H., Khosla, M.C. and Santos, R.A. ( 1994) Plasma angiotensin(1-7) immunoreactivity is increased by salt load, water deprivation, and hemorrhage. Peptides 15: 723-729.
4. Bradford, M.M. ( 1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254.
5. Castro, C.H., Santos, R.A., Ferreira, A.J., Bader, M., Alenina, N. and Almeida, A.P. ( 2005) Evidence for a functional interaction of the angiotensin-(1-7) receptor Mas with At 1 and At 2 receptors in the mouse heart. Hypertension 46: 937-942.
6. de Mello, W.C. ( 2004) Angiotensin (1-7) Reestablishes impulse conduction in cardiac muscle during ischaemia-reperfusion. The role of the sodium pump. J Renin Angiotensin Aldosterone Syst 5: 203-208.
7. de Mello, W.C., Ferrario, C.M. and Jessup, J.A. ( 2007) Beneficial versus harmful effects of angiotensin (1-7) on impulse propagation and cardiac arrhythmias in the failing heart. J Renin Angiotensin Aldosterone Syst 8: 74-80.
8. Dias-Peixoto, M.F., Santos, R.A., Gomes, E.R., Alves, M.N., Almeida, P.W., Greco, L. et al. (2008) Molecular mechanisms involved in the angiotensin-(1-7)/Mas signaling pathway in cardiomyocytes. Hypertension 52: 542-548.
9. Diez-Freire, C., Vazquez, J., Correa de Adjounian, M.F., Ferrari, M.F., Yuan, L., Silver, X. et al. (2006) ACE 2 gene transfer attenuates hypertension-linked pathophysiological changes in the SHR. Physiol Genomics 27: 12-19.
10. Ferrario, C.M. and Chappell, M.C. ( 2004) Novel angiotensin peptides. Cell Mol Life Sci 61: 2720-2727.
11. Ferreira, A.J., Oliveira, T.L., Castro, M.C., Almeida, A.P., Castro, C.H., Caliari, M.V. et al. (2007) Isoproterenol-induced impairment of heart function and remodeling are attenuated by the nonpeptide angiotensin-(1-7) analogue AVE 0991. Life Sci 81: 916-923.
12. Ferreira, A.J., Santos, R.A. and Almeida, A.P. ( 2001) Angiotensin-(1-7): cardioprotective effect in myocardial ischemia/reperfusion. Hypertension 38: 665-668.
13. Ferreira, A.J., Santos, R.A. and Almeida, A.P. ( 2002) Angiotensin-(1-7) improves the post-ischemic function in isolated perfused rat hearts. Braz J Med Biol Res 35: 1083-1090.
14. Grobe, J.L., Mecca, A.P., Lingis, M., Shenoy, V., Bolton, T.A., Machado, J.M. et al. (2007) Prevention of angiotensin II-induced cardiac remodeling by angiotensin-(1-7). Am J Physiol Heart Circ Physiol 292: H736-H742
15. Grobe, J.L., Mecca, A.P., Mao, H. and Katovich, M.J. ( 2006) Chronic angiotensin-(1-7) prevents cardiac fibrosis in Doca-Salt model of hypertension. Am J Physiol Heart Circ Physiol 290: H2417-H2423
16. Guatimosim, S., Sobie, E.A., Dos Santos Cruz, J., Martin, L.A. and Lederer, W.J. ( 2001) Molecular identification of a TTX-sensitive Ca(2+) current. Am J Physiol Cell Physiol 280: C1327-C1339
17. Hein, L., Stevens, M.E., Barsh, G.S., Pratt, R.E., Kobilka, B.K. and Dzau, V.J. ( 1997) Overexpression of angiotensin AT 1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block. Proc Natl Acad Sci U S A 94: 6391-6396.
18. Lauton-Santos, S., Guatimosim, S., Castro, C.H., Oliveira, F.A., Almeida, A.P., Dias-Peixoto, M.F. et al. (2007) Kinin B 1 receptor participates in the control of cardiac function in mice. Life Sci 81: 814-822.
19. Lochard, N., Silversides, D.W., van Kats, J.P., Mercure, C. and Reudelhuber, T.L. ( 2003) Brain-specific restoration of angiotensin II corrects renal defects seen in angiotensinogen-deficient mice. J Biol Chem 278: 2184-2189.
20. Loot, A.E., Roks, A.J., Henning, R.H., Tio, R.A., Suurmeijer, A.J., Boomsma, F. et al. (2002) Angiotensin-(1-7) attenuates the development of heart failure after myocardial infarction in rats. Circulation 105: 1548-1550.
21. Mahmood, A., Jackman, H.L., Teplitz, L. and Igic, R. ( 2002) Metabolism of angiotensin I in the coronary circulation of normal and diabetic rats. Peptides 23: 1171-1175.
22. Mercure, C., Yogi, A., Callera, G.E., Aranha, A.B., Bader, M., Ferreira, A.J. et al. (2008) Angiotensin(1-7) blunts hypertensive cardiac remodeling by a direct effect on the heart. Circ Res 103: 1319-1326.
23. Methot, D., Lapointe, M.C., Touyz, R.M., Yang, X.P., Carretero, O.A., Deschepper, C.F. et al. (1997) Tissue targeting of angiotensin peptides. J Biol Chem 272: 12994-12999.
24. Methot, D., Vankats, J.P., Lochard, N., Tremblay, F., Silversides, D.W. and Reudelhuber, T.L. ( 2001) Development and application of a biological peptide pump for the study of the in vivo actions of angiotensin peptides. Am J Hypertens 14: 38S-43S.
25. Neves, L.A., Almeida, A.P., Khosla, M.C. and Santos, R.A. ( 1995) Metabolism of angiotensin I in isolated rat hearts. effect of angiotensin converting enzyme inhibitors. Biochem Pharmacol 50: 1451-1459.
26. Pan, C.H., Wen, C.H. and Lin, C.S. ( 2008) Interplay of angiotensin II and angiotensin(1-7) in the regulation of matrix metalloproteinases of human cardiocytes. Exp Physiol 93: 599-612.
27. Paradis, P., Dali-Youcef, N., Paradis, F.W., Thibault, G. and Nemer, M. ( 2000) Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling. Proc Natl Acad Sci U S A 97: 931-936.
28. Popova, E., Krivokharchenko, A., Ganten, D. and Bader, M. ( 2002) Comparison between PMSG- and FSH-induced superovulation for the generation of transgenic rats. Mol Reprod Dev 63: 177-182.
29. Santos, R.A., Brum, J.M., Brosnihan, K.B. and Ferrario, C.M. ( 1990) The renin-angiotensin system during acute myocardial ischemia in dogs. Hypertension 15: 1121-127.
30. Santos, R.A., Castro, C.H., Gava, E., Pinheiro, S.V., Almeida, A.P., Paula, R.D. et al. (2006) Impairment of in vitro and in vivo heart function in angiotensin-(1-7) receptor Mas knockout mice. Hypertension 47: 996-1002.
31. Santos, R.A., Ferreira, A.J., Nadu, A.P., Braga, A.N., de Almeida, A.P., Campagnole-Santos, M.J. et al. (2004) Expression of an angiotensin-(1-7)-producing fusion protein produces cardioprotective effects in rats. Physiol Genomics 17: 292-299.
32. Santos, R.A., Ferreira, A.J., Pinheiro, S.V., Sampaio, W.O., Touyz, R. and Campagnole-Santos, M.J. ( 2005) Angiotensin-(1-7) and its receptor as a potential targets for new cardiovascular drugs. Expert Opin Investig Drugs 14: 1019-1031.
33. van Kats, J.P., Methot, D., Paradis, P., Silversides, D.W. and Reudelhuber, T.L. ( 2001) Use of a biological peptide pump to study chronic peptide hormone action in transgenic mice. Direct and indirect effects of angiotensin II on the heart. J Biol Chem 276: 44012-44017.