CD4+ effector and memory cell populations protect against Cryptosporidium parvum infection

Microbes and Infection

Volumn 15, Issue 8-9, 2013, Pages 599-606

  McNair, Nina N ^a,b   Mead, Jan R ^a,b  

^a ATLANTA VA MEDICAL CENTER   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CD4+ T cells; CD62L expression; Cryptosporidium parvum; Memory

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; L SELECTIN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL POPULATION; CONTROLLED STUDY; CRYPTOSPORIDIOSIS; DENDRITIC CELL; EFFECTOR CELL; FEMALE; FLOW CYTOMETRY; IMMUNE RESPONSE; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REINFECTION;

CD4(+) T CELLS; CD62L EXPRESSION; CRYPTOSPORIDIUM PARVUM; MEMORY;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD; CD4-POSITIVE T-LYMPHOCYTES; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; DISEASE MODELS, ANIMAL; FEMALE; FLOW CYTOMETRY; IMMUNOLOGIC MEMORY; IMMUNOPHENOTYPING; MICE; MICE, INBRED C57BL;

CRYPTOSPORIDIUM PARVUM; PROTOZOA;

EID: 84880642450     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2013.04.009     Document Type: Article

References (26)

1. Leitch G.J. He Q cryptosporidiosis - an overview. J. Biomed. Res. 2012, 25:1-16.
2. Borad A., Ward H. Human immune responses in cryptosporidiosis. Future Microbiol. 2010, 3:507-519.
3. Frost F.J., Muller T.B., Calderon R.L., Craun G.F. Analysis of serological responses to Cryptosporidium antigen among NHANES III participants. Ann. Epidemiol. 2004, 14:473-478.
4. Priest J.W., Bern C., Xiao L., Roberts J.M., Kwon J.P., Lescano A.G., Checkley W., Cabrera L., Moss D.M., Arrowood M.J., Sterling C.R., Gilman R.H., Lammie P.J. Longitudinal analysis of Cryptosporidium species-specific immunoglobulin G antibody responses in Peruvian children. Clin. Vaccine Immunol. 2006, 13:123-131.
5. Okhuysen P.C., Chappell C.L., Sterling C.R., Jakubowski W., DuPont H.L. Susceptibility and serologic response of healthy adults to reinfection with Cryptosporidium parvum. Infect. Immun. 1998, 66:441-443.
6. Ahmed R., Bevan M.J., Reiner S.L., Fearon D.T. The precursors of memory: models and controversies. Nat. Rev. Immunol. 2009, 9:662-668.
7. Baaten B.J., Li C.R., Deiro M.F., Lin M.M., Linton P.J., Bradley L.M. CD44 regulates survival and memory development in Th1 cells. Immunity 2010, 32:104-115.
8. Campbell L.D., Stewart J.N., Mead J.R. Susceptibility to Cryptosporidium parvum infections in cytokine and chemokine-receptor knockout mice. J. Parasitol. 2002, 88:1014-1016.
9. Ehigiator H.N., McNair N., Mead J.R. IL-12 knockout C57BL/6 mice are protected from re-infection with Cryptosporidium parvum after challenge. J. Eukaryot. Microbiol. 2003, 50:539-541.
10. Arrowood M.J., Donaldson K. Improved purification methods for calf-derived Cryptosporidium parvum oocysts using discontinuous sucrose and cesium chloride gradients. J. Eukaryot. Microbiol. 1996, 43:89-90.
11. Ehigiator H.N., Romagnoli P., Borgelt K., Fernandez M., McNair N., Secor W.E., Mead J.R. Mucosal cytokine and antigen-specific responses to Cryptosporidium parvum in IL-12p40 KO mice. Parasite Immunol. 2005, 27:17-28.
12. Segal D.M. Measurement of intercellular conjugates by flow cytometry. Current Protocols in Immunology 2012, John Wiley and Sons, Inc., Hoboken, NJ, Wiley on line, Unit 5.6.
13. Bedi B., Mead J.R. Cryptosporidium parvum antigens induce mouse and human dendritic cells to generate Th1-enhancing cytokine. Parasite Immunol. 2012, 34:473-485.
14. Benitez A.J., McNair N., Mead J.R. Oral immunization with attenuated Salmonella enterica serovar Typhimurium encoding Cryptosporidium parvum Cp23 and Cp40 antigens induces a specific immune response in mice. Clin. Vaccine Immunol. 2009, 16:1272-1278.
15. Arrowood M.J., Hurd M.R., Mead J.R. A new method for evaluating experimental cryptosporidial parasite loads using immunofluorescent flow cytometry. J. Parasitol. 1995, 81:404-409.
16. McDonald V. Cryptosporidiosis: host immune responses and the prospects for effective immunotherapies. Expert Rev. Anti-Infect Ther. 2011, 9:1077-1086.
17. Masopust D., Choo D., Vezys V., Wherry E.J., Duraiswamy J., Akondy R., Wang J., Casey K.A., Barber D.L., Kawamura K.S., Fraser K.A., Webby R.J., Brinkmann V., Butcher E.C., Newell K.A., Ahmed R. Dynamic T cell migration program provides resident memory within intestinal epithelium. J. Exp. Med. 2010, 3:553-564.
18. Masopust D., Vezys V., Usherwood E.J., Cauley L.S., Olson S., Marzo A.L., Ward R.L., Woodland D.L., Lefrançois L. Activated primary and memory CD8 T cells migrate to nonlymphoid tissues regardless of site of activation or tissue of origin. J. Immunol. 2004, 172:4875-4882.
19. Tessema T.S., Dauber E., Petry F. Adoptive transfer of protective immunity from Cryptosporidium parvum-infected interferon-gamma and interleukin-12 deficient mice to naïve recipients. Vaccine 2009, 47:6575-6581.
20. + T cell population generated during Leishmania major infection requires IL-12 to produce IFN-gamma. J. Immunol. 2008, 180:8299-8305.
21. Stobie L., Gurunathan S., Prussin C., Sacks D.L., Glaichenhaus N., Wu C.Y., Seder R.A. The role of antigen and IL-12 in sustaining Th1 memory cells invivo: IL-12 is required to maintain memory/effector Th1 cells sufficient to mediate protection to an infectious parasite challenge. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:8427-8432.
22. + T cell memory is regulated by IL-12. J. Immunol. 2007, 179:2074-2081.
23. + T cells. PLoS Pathog. 2010, 6:e1000815.
24. Mueller S.N., Gebhardt T., Carbone F.R., Heath W.R. Memory T cell subsets, migration patterns, and tissue residence. Annu. Rev. Immunol. 2012, 31:137-161.
25. + T cells following infection with a gastrointestinal helminth. J. Immunol. 2006, 177:511-518.
26. Krawczyk C.M., Shen H., Pearce E.J. Memory CD4 T cells enhance primary CD8 T-cell responses. Infect. Immun. 2007, 74:3556-3560.