Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 16, 2013, Pages 4591-4596

  Scott, David A ^a   Dakin, Les A ^a   Daly, Kevin ^a   Del Valle, David J ^a   Diebold, R Bruce ^a   Drew, Lisa ^a   Ezhuthachan, Jayachandran ^a   Gero, Thomas W ^a   Ogoe, Claude A ^a   Omer, Charles A ^a   Redmond, Sean P ^a   Repik, Galina ^a   Thakur, Kumar ^a   Ye, Qing ^a   Zheng, Xiaolan ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

CSF 1R; Inhibitor; Kinase

Indexed keywords

3 AMIDO 4 ANILINOQUINOLINE; AZ 683; AZD 7507; CINOXACIN; ENZYME INHIBITOR; ION CHANNEL; QUINOLINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CARDIOTOXICITY; DRUG POTENCY; IC 50; NONHUMAN; RAT; SAFETY; SCREENING;

CSF-1R; INHIBITOR; KINASE;

AMINOQUINOLINES; ANILINE COMPOUNDS; ANIMALS; CARDIOVASCULAR SYSTEM; CELLS, CULTURED; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GUINEA PIGS; HETEROCYCLIC COMPOUNDS, 2-RING; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; MYOCYTES, CARDIAC; RATS; RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR;

EID: 84880633133     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.06.031     Document Type: Article

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