Reducing ion channel activity in a series of 4-heterocyclic arylamide FMS inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 13, 2010, Pages 3925-3929

  Wilson, Kenneth J ^a   Illig, Carl R ^a   Chen, Jinsheng ^a   Wall, Mark J ^a   Ballentine, Shelley K ^a   Desjarlais, Renee L ^a   Chen, Yanmin ^a   Schubert, Carsten ^a   Donatelli, Robert ^a   Petrounia, Ioanna ^a   Crysler, Carl S ^a   Molloy, Christopher J ^a   Chaikin, Margery A ^a   Manthey, Carl L ^a   Player, Mark R ^a   Tomczuk, Bruce E ^a   Meegalla, Sanath K ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Anti inflammatory activity; Colony stimulating factor 1; CSF 1R; FMS; M CSF; Macrophages

Indexed keywords

4 ARYL IMIDAZOYL AMIDE; 4 PYRIDYL IMIDAZOYL AMIDE; AROMATIC AMIDE; COLONY STIMULATING FACTOR 1; ION CHANNEL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BIOAVAILABILITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG BLOOD LEVEL; IC 50; NONHUMAN; RAT; X RAY CRYSTALLOGRAPHY;

AMIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; HETEROCYCLIC COMPOUNDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; PROTEIN KINASE INHIBITORS; RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77954313375     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.05.013     Document Type: Article

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