Relationship between Genetic Polymorphisms in the HTR1A Gene and Paranoid Schizophrenia in a Northern Han Chinese Population

Journal of Molecular Neuroscience

Volumn 49, Issue 3, 2013, Pages 625-631

  Zhou, Xue ^a   Ding, Mei ^a   Ding, Chunli ^a   Yao, Jun ^a   Pang, Hao ^a   Xing, Jiaxin ^a   Xuan, Jinfeng ^a   Wang, Baojie ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

HTR1A; Paranoid schizophrenic; Polymorphism; SNP

Indexed keywords

ADULT; ARTICLE; BINDING AFFINITY; CHINESE; CONTROLLED STUDY; DNA SEQUENCE; EXON; FEMALE; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; LIGAND BINDING; MAJOR CLINICAL STUDY; MALE; PARANOID SCHIZOPHRENIA; SAMPLE SIZE; AMINO ACID SUBSTITUTION; CASE CONTROL STUDY; CHEMISTRY; CHINA; ETHNIC GROUP; ETHNOLOGY; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; MISSENSE MUTATION; PHYSIOLOGY; PROMOTER REGION; PROTEIN CONFORMATION; SINGLE NUCLEOTIDE POLYMORPHISM; STRUCTURE ACTIVITY RELATION;

MAMMALIA;

SEROTONIN; SEROTONIN 1A RECEPTOR;

ADULT; AMINO ACID SUBSTITUTION; CASE-CONTROL STUDIES; CHINA; ETHNIC GROUPS; EXONS; FEMALE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; MUTATION, MISSENSE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; PROTEIN CONFORMATION; RECEPTOR, SEROTONIN, 5-HT1A; SCHIZOPHRENIA, PARANOID; SEROTONIN; STRUCTURE-ACTIVITY RELATIONSHIP;

MLCS; MLOWN;

EID: 84880594949     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-012-9928-9     Document Type: Article

References (25)

1. Burnet PW, Eastwood SL, Harrison PJ (1996) 5-HT1A and 5-HT2A receptor mRNAs and binding site densities are differentially altered in schizophrenia. Neuropsychopharmacology 15(5):442-455
2. David SP, Johnstone EC, Murphy MFG et al (2008) Genetic variation in the serotonin pathway and smoking cessation with nicotine replacement therapy: new data from the Patch in Practice trial and pooled analyses. Drug Alcohol Depend 98:77-85
3. Geyer MA, Vollenweider FX (2008) Serotonin research: contributions to understanding psychoses. Trends Pharmacol Sci 29(9):445-453
4. Hashimoto T, Nishino N, Nakai H et al (1991) Increase in serotonin 5-HT1A receptors in prefrontal and temporal cortices of brains from patients with chronic schizophrenia. Life Sci 48(4):355-363
5. Hashimoto T, Kitamura N, Kajimoto Y et al (1993) Differential changes in serotonin 5-HT1A and 5-HT2 receptor binding in patients with chronic schizophrenia. Psychopharmacology (Berl) 112(1 Suppl):S35-S39
6. Hong L, Jianxun L (2003) Progress of research on pathogenic genes of schizophrenia. Ment Illn Ment Health 3(3):231-232
7. Huang YY, Battistuzzi C, Oquendo MA et al (2004) Human 5-HT1A receptor C (-1019) G polymorphism and psychopathology. Int J Neuropsychopharm 7(4):441-451
8. Kawanishi Y, Harada S, Tachikawa H et al (1998) Novel mutations in the promoter and coding region of the human 5-HT1A receptor gene and association analysis in schizophrenia. Am J Med Genet (Neuropsychiatr Genet) 81(5):434-439
9. Kishi T, Tsunoka T, Ikeda M et al (2010a) Serotonin 1A receptor gene is associated with Japanese methamphetamine-induced psychosis patients. Neuropharma 58(2):452-456
10. Kishi T, Tsunoka T, Ikeda M et al (2010b) Serotonin 1A receptor gene is associated with Japanese methamphetamine-induced psychosis patients. Neuropharm 58(2):452-456
11. Lemonde S, Turecki G, Bakish D et al (2003) Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. J Neurosci 23(25):8788-8799
12. McGuffine ME, Chandler D, Somaiya D et al (1998) Autoregulation of transformer-2 alternative splicing is necessary for normal male fertility in Drosophila. Genet 149(3):1477-1486
13. Mclarren KW, Theriault FM, Stifani S (2001) Association with the nuclear matrix and interaction with Groucho and RUNX proteins regulate the transcription repression activity of the basic helix loop helix factor Hes1. J Biol Chem 276(2):1578-1584
14. Meltzer HY, Li Z, Kaneda Y et al (2003) Serotonin receptors: their key role in drugs to treat schizophrenia. Prog Neuro-Psychopharmacol Biol Psychiatry 27(7):1159-1172
15. Ou XM, Lemonde S, Jafar-Nejad H et al (2003) Freud-1: a neural calcium-regulated repressor of the 5-HT1A receptor gene. J Neurosic 23(19):7415-7425
16. Savitz J, Lucki I, Drevets WC et al (2009) 5-HT1A receptor function in major depressive disorder. Prog Neurobiol 88(1):17-31
17. Shaolin G (2003) Depression. People's Medical Publishing House, Beijing, pp 45-46
18. Strobel A, Gutknecht L, Rothe C et al (2003) Allelic variation in 5-HT1A receptor expression is associated with anxiety- and depression-related personality traits. J Neural Transm 110(2):1445-1463
19. Sullivan PF, Kendler KS, Neale MC et al (2003) Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch Gen Psychiat 60(12):1187-1192
20. Sumiyoshi T, Stockmeier CA, Overholser JC et al (1996) Serotonin1A receptors are increased in postmortem prefrontal cortex in schizophrenia. Brain Res 708(1-2):209-214
21. Szewczyk B, Albert PR, Burns AM et al (2009) Gender-specific decrease in NUDR and 5-HT1A receptor proteins in the prefrontal cortex of subjects with major depressive disorder. Int J Neuropsychopharm 12(2):155-168
22. World Health Organization (2001) WHO health report 2001 - mental health: new understanding, new hope. World Health Organization 33-34
23. Wu Y, Xu Y, Sun Y et al (2008) Association between the serotonin 1A receptor C (-1019) G polymorphism and major depressive disorder in the northern Han ethnic group in China. Chin Med J 121(10):874-876
24. Yu S (2002) Psychiatry. Beijing People's Medical Publishing House, Beijing, pp 393-412
25. Yu WY, Tsai SJ, Hong CJ et al (2006) Association study of two serotonin 1A receptor gene polymorphisms and fluoxetine treatment response in Chinese major depressive disorders. Eur Neuropsychopharm 16(7):498-503