Bioactivation of aromatic amines by human CYP2W1, an orphan cytochrome P450 enzyme

Toxicological Research

Volumn 26, Issue 3, 2013, Pages 171-175

  Eun, Chang Yong ^a   Han, Songhee ^a   Lim, Young Ran ^a   Park, Hyoung Goo ^a   Han, Jung Soo ^a   Cho, Kyoung Sang ^a   Chun, Young Jin ^b   Kim, Donghak ^a  

^a Konkuk University   (South Korea)

^b Chung Ang University   (South Korea)

Author keywords

Aromatic amines; CYP2W1

Indexed keywords

EID: 84880592815     PISSN: 19768257     EISSN: 22342753     Source Type: Journal    
DOI: 10.5487/TR.2010.26.3.171     Document Type: Article

References (20)

1. Arnold, K., Bordoli, L., Kopp, J. and Schwede, T. (2006). The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling. Bioinformatics, 22, 195-201.
2. Choudhary, D., Jansson, I., Stoilov, I., Sarfarazi, M. and Schenkman, J.B. (2005). Expression patterns of mouse and human CYP orthologs (families 1-4) during development and in different adult tissues. Arch. Biochem. Biophys., 436, 50-61.
3. Gomez, A., Karlgren, M., Edler, D., Bernal, M.L., Mkrtchian, S. and Ingelman-Sundberg, M. (2007). Expression of CYP2W1 in colon tumors: regulation by gene methylation. Pharmacogenomics, 8, 1315-1325.
4. Guengerich, F.P. (1993). Cytochrome P450 enzymes. American Scientist, 81, 440-447.
5. Guengerich, F.P. (2008). Cytochrome p450 and chemical toxicology. Chem. Res. Toxicol., 21, 70-83.
6. Guengerich, F.P., Tang, Z., Cheng, Q. and Salamanca-Pinzon, S.G. (2010a). Approaches to deorphanization of human and microbial cytochrome P450 enzymes. Biochim. Biophys. Acta., (in press).
7. Guengerich, F.P., Tang, Z., Salamanca-Pinzon, S.G. and Cheng, Q. (2010b). Characterizing proteins of unknown function: orphan cytochrome p450 enzymes as a paradigm. Mol. Interv., 10, 153-163.
8. Guengerich, F.P., Wu, Z.L. and Bartleson, C.J. (2005). Function of human cytochrome P450s: characterization of the orphans. Biochem. Biophys. Res. Commun., 338, 465-469.
9. Josephy, P.D. (2000). The Escherichia coli lacZ reversion mutagenicity assay. Mutat. Res., 455, 71-80.
10. Karlgren, M., Gomez, A., Stark, K., Svard, J., Rodriguez-Antona, C., Oliw, E., Bernal, M.L., Ramon y Cajal, S., Johansson, I. and Ingelman-Sundberg, M. (2006). Tumor-specific expression of the novel cytochrome P450 enzyme, CYP2W1. Biochem. Biophys. Res. Commun., 341, 451-458.
11. Kim, D. and Guengerich, F.P. (2005). Cytochrome P450 activation of arylamines and heterocyclic amines. Annu. Rev. Pharmacol. Toxicol., 45, 27-49.
12. Kim, D., Wu, Z.L. and Guengerich, F.P. (2005). Analysis of coumarin 7-hydroxylation activity of cytochrome P450 2A6 using random mutagenesis. J. Biol. Chem., 280, 40319-40327.
13. Li, W., Tang, Y., Hoshino, T. and Neya, S. (2009). Molecular modeling of human cytochrome P450 2W1 and its interactions with substrates. J. Mol. Graph. Model, 28, 170-176.
14. Nelson, D.R., Zeldin, D.C., Hoffman, S.M., Maltais, L.J., Wain, H.M. and Nebert, D.W. (2004). Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. Pharmacogenetics, 14, 1-18.
15. Omura, T. and Sato, R. (1964). The Carbon Monoxide-Binding Pigment of Liver Microsomes. I. Evidence for Its Hemoprotein Nature. J. Biol. Chem., 239, 2370-2378.
16. Rowland, P., Blaney, F.E., Smyth, M.G., Jones, J.J., Leydon, V.R., Oxbrow, A.K., Lewis, C.J., Tennant, M.G., Modi, S., Eggleston, D.S., Chenery, R.J. and Bridges, A.M. (2006). Crystal structure of human cytochrome P450 2D6. J. Biol. Chem., 281, 7614-7622.
17. Tang, Z., Martin, M.V. and Guengerich, F.P. (2009). Elucidation of functions of human cytochrome P450 enzymes: identification of endogenous substrates in tissue extracts using metabolomic and isotopic labeling approaches. Anal. Chem., 81, 3071-3078.
18. Wu, Z.L., Sohl, C.D., Shimada, T. and Guengerich, F.P. (2006). Recombinant enzymes overexpressed in bacteria show broad catalytic specificity of human cytochrome P450 2W1 and limited activity of human cytochrome P450 2S1. Mol. Pharmacol., 69, 2007-2014.
19. Yun, C.-H., Miller, G.P. and Guengerich, F.P. (2000). Rate-determining steps in phenacetin oxidations by human cytochrome P450 1A2 and selected mutants. Biochemistry, 39, 11319- 11329.
20. Zhou, H., Josephy, P.D., Kim, D. and Guengerich, F.P. (2004). Functional characterization of four allelic variants of human cytochrome P450 1A2. Arch. Biochem. Biophys., 422, 23-30.