A synthetic peptide corresponding to a region of the human pericentriolar material 1 (PCM-1) protein binds β-amyloid (Aβ1-42) oligomers

Journal of Neurochemistry

Volumn 126, Issue 3, 2013, Pages 415-424

  Chakravarthy, Balu ^a   Ménard, Michel ^a   Brown, Leslie ^a   Hewitt, Melissa ^a   Atkinson, Trevor ^a   Whitfield, James ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

A binding peptides; A 1 42 oligomers; Alzheimer's disease; PCM 1 protein

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; OLIGOMER; PERICENTRIOLAR MATERIAL 1 PROTEIN; POLYPEPTIDE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOT HYBRIDIZATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN BINDING;

AΒ-BINDING PEPTIDES; AΒ1-42 OLIGOMERS; ALZHEIMER'S DISEASE; PCM-1 PROTEIN;

AMINO ACID SEQUENCE; AMYLOID BETA-PEPTIDES; ANIMALS; AUTOANTIGENS; BLOTTING, WESTERN; CELL CYCLE PROTEINS; CELL LINE, TUMOR; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN STRUCTURE, TERTIARY;

MUS MUSCULUS;

EID: 84880572467     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12208     Document Type: Article

References (13)

1. Balczon R., Bao L., and, Zimmer W. E., (1994) PCM-1, a 228-kD centrosome autoantigen with a distinct cell cycle distribution. J. Cell Biol. 124, 783-793.
2. Barbier J.-R., Neugebauer W., Morley P., Ross V., Soska M., Whitfield J. F., and, Willick G., (1997) Bioactivities and secondary structures of constrained analogues of human parathyroid hormone: cyclic lactams of the receptor binding region. J. Med. Chem. 40, 1373-1380.
3. Borysov S. I., Granic A., Padmanabhan J., Walczak C. E., and, Potter H., (2011) Alzheimer Aβ disrupts the mitotic spindle and directly inhibits mitotic microtubule motors. Cell Cycle 10, 1397-1410.
4. Bourhim M., Kruzel M., Srikrishnan T., and, Nicotera T., (2007) Linear quantitation of Abeta aggregation using Thioflavin T: reduction in fibril formation by colostrinin. J. Neurosci. Methods 160, 264-268.
5. NTR neurotrophin receptor in SHSY5Y human neuroblastoma cells and AD transgenic mice. J. Alzheimers Dis. 19, 915-925.
6. Chakravarthy B., Ménard M., Brown L., Atkinson T., and, Whitfield J., (2012) Identification of protein kinase C inhibitory activity associated with a polypeptide isolated from a phage display system with homology to PCM-1, the pericentriolar material-1 protein. Biochem. Biophys. Res. Commun. 424, 147-151.
7. Chen D., Purohit A., Halilovic E., Doxsey S. J., and, Newton A. C., (2004) Centrosomal anchoring of protein kinase C βII by pericentrin controls microtubule organization, spindle function, and cytokinesis. J. Biol. Chem. 279, 4829-4839.
8. Choy R. W., Cheng Z., and, Schekman R., (2012) Amyloid precursor protein (APP) traffic from the cell surface via endosomes for amyloid β (Aβ) production in the trans-Golgi network. Proc. Natl Acad. Sci. USA 109, E2077-E2082.
9. Ge X., Frank C. L., Calderon de Anda F., and, Tsai L. H., (2010) Hook 3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis. Neuron 65, 191-203.
10. Lobello K., Ryan J. M., Liu E., Rippon G., and, Black R., (2012) Targeting Beta Amyloid: a clinical review of immunotherapeutic approaches in Alzheimer's disease. Int. J. Alzheimers Dis. 2012, 1-14.
11. Oddo S., Caccamo A., Shepherd J. D., Murphy M. P., Golde T. E., Kayed R., Metherate R., Mattson M. P., Akbari Y., and, LaFerla F. M., (2003) Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 39, 409-421.
12. Ou Y., Zhang M., and, Rattner J. B., (2004) The centrosome:the centriole-PCM coalition. Cell Motil. Cytoskel. 57, 1-7.
13. Selkoe D. J., Mandelkow E., and, Holzman D. M., (2012) The Biology of Alzheimer's Disease. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.