Identification of protein kinase C inhibitory activity associated with a polypeptide isolated from a phage display system with homology to PCM-1, the pericentriolar material-1 protein

Biochemical and Biophysical Research Communications

Volumn 424, Issue 1, 2012, Pages 147-151

  Chakravarthy, Balu ^a   Ménard, Michel ^a   Brown, Leslie ^a   Atkinson, Trevor ^a   Whitfield, James ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Inhibitor; Pericentriolar material 1 (PCM 1) protein; Phage display; Protein kinase C (PKC)

Indexed keywords

COMPLEMENTARY DNA; PERICENTRIOLAR MATERIAL 1 PROTEIN; POLYPEPTIDE; PROTEIN KINASE C; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BIOLOGICAL ACTIVITY; CLONE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR LIBRARY; NONHUMAN; NUCLEOTIDE SEQUENCE; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN ISOLATION; RAT; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; AUTOANTIGENS; CELL CYCLE PROTEINS; GENE LIBRARY; HUMANS; MICE; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PEPTIDES; PROTEIN KINASE C; PROTEIN KINASE INHIBITORS; RATS; RECOMBINANT PROTEINS;

BACTERIA (MICROORGANISMS); ENTEROBACTERIA PHAGE T7; MURINAE; RATTUS;

EID: 84864086890     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.06.093     Document Type: Article

References (13)

1. Chakravarthy B.R., Wong J., Durkin J.P. Evidence that the modulation of membrane-associated protein kinase C (PKC) by an endogenous inhibitor plays a role in N1E-115 murine neuroblastoma cell differentiation. J. Neurochem. 1995, 65:1569-1579.
2. Balczon R., Bao L., Zimmer W.E. PCM-1, a 228-kD centrosome autoantigen with a distinct cell cycle distribution. J. Cell Biol. 1994, 124:783-793.
3. Ge X., Frank C.L., Calderon de Anda F., Tsai L.H. Hook 3 interacts with PCM1 to regulate pericentriolar material assembly and the timing of neurogenesis. Neuron 2010, 65:191-203.
4. Ou Y., Zhang M., Rattner J.B. The centrosome:the centriole-PCM coalition. Cell Motil. Cytoskeleton 2004, 57:1-7.
5. Delaval B., Doxsey S.J. Pericentrin in cellular function and disease. J. Cell Biol. 2010, 188:181-190.
6. Li Q., Hansen D., Killilea A., Joshi H.C., Palazzo R.E., Balczon R. Kendrin/pericentrin-B, a centrosome protein with homology to pericentrin that complexes with PCM-1. J. Cell Sci. 2001, 114:797-809.
7. Chen D., Purohit A., Halilovic E., Doxsey S.J., Newton A.C. Centrosomal anchoring of protein kinase C βII by pericentrin controls microtubule organization, spindle function, and cytokinesis. J. Biol. Chem. 2004, 279:4829-4839.
8. Kubo A., Sasaki H., Yuba-Kubo A., Tsukita S., Ahiina N.S. Centriolar satellites:molecular characterization, ATP-dependent movement toward centrioles and possible involvement in ciliogenesis. J. Cell Biol. 1999, 147:969-971.
9. Keryer G., Pineda J.R., Liot G., Kim J., Dietrich P., Bernstaali C., Smith K., Cordelières F.P., Spassky N., Ferrante R.J., Dragatsis I., Saudou F. Ciliogenesis is regulated by a huntingtin-HAP1-PCM-1 pathway and is altered in Huntington disease. J. Clin. Invest. 2011, 121:4372-4382.
10. Liu J.-P., Zeitlin S.O. The long and the short of aberrant ciliogenesis in Huntington's disease. J. Clin. Invest. 2011, 121:4237-4241.
11. Chakravarthy B.R., Bussey A., Whitfield J.F., Sikorska M., Williams R.E., Durkin J.D. The direct measurement of protein kinase C (PKC) activity in isolated membranes using a selective peptide substrate. Anal. Biochem. 1991, 196:144-150.
12. Chakravarthy B.R., Walker T., Rasquinha I., Hill I.E., MacManus J.P. Activation of DNA-dependent protein kinase may play a role in apoptosis of human neuroblastoma cells. J. Neurochem. 1999, 72:933-942.
13. McGuinness T.L., Lai Y., Greengard P. Ca2+/calmodulin-dependent protein kinase II. Isozymic forms from rat forebrain and cerebellum. J. Biol. Chem. 1985, 260:1696-1704.