Gene expression of carnosine-related enzymes and transporters in skeletal muscle

European Journal of Applied Physiology

Volumn 113, Issue 5, 2013, Pages 1169-1179

  Everaert, Inge ^a   De Naeyer, Hélène ^a   Taes, Youri ^b   Derave, Wim ^a  

^a GHENT UNIVERSITY   (Belgium)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Beta alanine aminotransferase; Beta alanine supplementation; Orchidectomy; Testosterone

Indexed keywords

AMINOACYL-HISTIDINE DIPEPTIDASE; AMINOACYLHISTIDINE DIPEPTIDASE; BETA ALANINE; BETA ALANINE PYRUVATE AMINOTRANSFERASE; CARNOSINE; CARNOSINE SYNTHASE; CARRIER PROTEIN; DIPEPTIDASE; DIPEPTIDE; HISTIDINE DECARBOXYLASE; PEPTIDE SYNTHASE; TESTOSTERONE;

ADULT; ANIMAL; ARTICLE; BIOSYNTHESIS; ENZYMOLOGY; FEMALE; GENETIC TRANSCRIPTION; GENETICS; HUMAN; MALE; METABOLISM; MOUSE; ORCHIECTOMY; SKELETAL MUSCLE;

ADULT; ANIMALS; BETA-ALANINE; BETA-ALANINE-PYRUVATE TRANSAMINASE; CARNOSINE; DIPEPTIDASES; DIPEPTIDES; FEMALE; HISTIDINE DECARBOXYLASE; HUMANS; MALE; MEMBRANE TRANSPORT PROTEINS; MICE; MUSCLE, SKELETAL; ORCHIECTOMY; PEPTIDE SYNTHASES; TESTOSTERONE; TRANSCRIPTION, GENETIC;

EID: 84876305879     PISSN: 14396319     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00421-012-2540-4     Document Type: Article

References (39)

1. Agu R, Cowley E, Shao D, Macdonald C, Kirkpatrick D, Renton K, Massoud E (2011) Proton-coupled oligopeptide transporter (POT) family expression in human nasal epithelium and their drug transport potential. Mol Pharm 8:664-672
2. -)-dependent TauT (SLC6A6). J Physiol 587:731-744
3. Baguet A, Reyngoudt H, Pottier A, Everaert I, Callens S, Achten E, Derave W (2009) Carnosine loading and washout in human skeletal muscles. J Appl Physiol 106:837-842
4. Baguet A, Koppo K, Pottier A, Derave W (2010) Beta-alanine supplementation reduces acidosis but not oxygen uptake response during high-intensity cycling exercise. Eur J Appl Physiol 108:495-503
5. Baguet A, Everaert I, Achten E, Thomis M, Derave W (2012) The influence of sex, age and heritability on human skeletal muscle carnosine content. Amino Acids 43:13-20
6. Bakardjiev A, Bauer K (1994) Transport of beta-alanine and biosynthesis of carnosine by skeletal muscle cells in primary culture. Eur J Biochem 225:617-623
7. Batrukova MA, Rubtsov AM (1997) Histidine-containing dipeptides as endogenous regulators of the activity of sarcoplasmic reticulum Ca-release channels. Biochim Biophys Acta 1324:142-150
8. Botka CW, Wittig TW, Graul RC, Nielsen CU, Higaka K, Amidon GL, Sadee W (2000) Human proton/oligopeptide transporter (POT) genes: identification of putative human genes using bioinformatics. AAPS PharmSci 2:E16
9. Brooks GA (1987) Amino acid and protein metabolism during exercise and recovery. Med Sci Sports Exerc 19:S150-S156
10. Daniel H (2004) Molecular and integrative physiology of intestinal peptide transport. Annu Rev Physiol 66:361-384
11. Del Favero S, Roschel H, Solis MY, Hayashi AP, Artioli GG, Otaduy MC, Benatti FB, Harris RC, Wise JA, Leite CC, Pereira RM, de Sa-Pinto AL, Lancha-Junior AH, Gualano B (2012) Beta-alanine (Carnosyn) supplementation in elderly subjects (60-80 years): effects on muscle carnosine content and physical capacity. Amino Acids 43:49-65
12. Derave W, Everaert I, Beeckman S, Baguet A (2010) Muscle carnosine and beta-alanine in relation to exercise and training. Sports Med 40:247-263
13. Derveaux S, Vandesompele J, Hellemans J (2010) How to do successful gene expression analysis using real-time PCR. Methods 50:227-230
14. Doring F, Walter J, Will J, Focking M, Boll M, Amasheh S, Clauss W, Daniel H (1998) Delta-aminolevulinic acid transport by intestinal and renal peptide transporters and its physiological and clinical implications. J Clin Invest 101:2761-2767
15. Drozak J, Veiga-da-Cunha M, Vertommen D, Stroobant V, Van Schaftingen E (2010) Molecular identification of carnosine synthase as ATP-grasp domain-containing protein 1 (ATPGD1). J Biol Chem 285:9346-9356
16. Drummond MJ, Glynn EL, Fry CS, Timmerman KL, Volpi E, Rasmussen BB (2010) An increase in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle. Am J Physiol Endocrinol Metab 298:E1011-E1018
17. Dunnett M, Harris RC (1999) Influence of oral beta-alanine and l-histidine supplementation on the carnosine content of the gluteus medius. Equine Vet J Suppl 30:499-504
18. Dutka TL, Lamb GD (2004) Effect of carnosine on excitation-contraction coupling in mechanically-skinned rat skeletal muscle. J Muscle Res Cell Motil 25:203-213
19. 2+ release in human skeletal muscle fibers. J Appl Physiol 112:728-736
20. Everaert I, Mooyaart A, Baguet A, Zutinic A, Baelde H, Achten E, Taes Y, de Heer E, Derave W (2011) Vegetarianism, female gender and increasing age, but not CNDP1 genotype, are associated with reduced muscle carnosine levels in humans. Amino Acids 40:1221-1229
21. Everaert I, Stegen S, Vanheel B, Taes Y, Derave W (2012) Effect of beta-alanine and carnosine supplementation on muscle contractility in mice. Med Sci Sports Exerc [Epub ahead of print]
22. Harris RC, Tallon MJ, Dunnett M, Boobis L, Coakley J, Kim HJ, Fallowfield JL, Hill CA, Sale C, Wise JA (2006) The absorption of orally supplied beta-alanine and its effect on muscle carnosine synthesis in human vastus lateralis. Amino Acids 30:279-289
23. Hill CA, Harris RC, Kim HJ, Harris BD, Sale C, Boobis LH, Kim CK, Wise JA (2007) Influence of beta-alanine supplementation on skeletal muscle carnosine concentrations and high intensity cycling capacity. Amino Acids 32:225-233
24. Hobson RM, Saunders B, Ball G, Harris RC, Sale C (2012) Effects of beta-alanine supplementation on exercise performance: a meta-analysis. Amino Acids 43:25-37
25. Iruloh CG, D'Souza SW, Speake PF, Crocker I, Fergusson W, Baker PN, Sibley CP, Glazier JD (2007) Taurine transporter in fetal T lymphocytes and platelets: differential expression and functional activity. Am J Physiol Cell Physiol 292:C332-C341
26. Ito S, Ohyama T, Kontani Y, Matslida K, Sakata SF, Tamaki N (2001) Influence of dietary protein levels on beta-alanine aminotransferase expression and activity in rats. J Nutr Sci Vitaminol (Tokyo) 47:275-282
27. Kamal MA, Jiang H, Hu Y, Keep RF, Smith DE (2009) Influence of genetic knockout of Pept2 on the in vivo disposition of endogenous and exogenous carnosine in wild-type and Pept2 null mice. Am J Physiol Regul Integr Comp Physiol 296:R986-R991
28. Lenney JF, Peppers SC, Kucera-Orallo CM, George RP (1985) Characterization of human tissue carnosinase. Biochem J 228:653-660
29. Lu H, Klaassen C (2006) Tissue distribution and thyroid hormone regulation of Pept1 and Pept2 mRNA in rodents. Peptides 27:850-857
30. Ma K, Hu Y, Smith D (2011) Influence of fed-fasted state on intestinal PEPT1 expression and in vivo pharmacokinetics of glycylsarcosine in wild-type and Pept1 knockout mice. Pharm Res 29:535-545
31. Mannion AF, Jakeman PM, Dunnett M, Harris RC, Willan PL (1992) Carnosine and anserine concentrations in the quadriceps femoris muscle of healthy humans. Eur J Appl Physiol Occup Physiol 64:47-50
32. Nagai K, Tanida M, Niijima A, Tsuruoka N, Kiso Y, Horii Y, Shen J, Okumura N (2012) Role of l-carnosine in the control of blood glucose, blood pressure, thermogenesis, and lipolysis by autonomic nerves in rats: involvement of the circadian clock and histamine. Amino Acids 43:97-109
33. Niijima-Yaoita F, Tsuchiya M, Ohtsu H, Yanai K, Sugawara S, Endo Y, Tadano T (2012) Roles of histamine in exercise-induced fatigue: favouring endurance and protecting against exhaustion. Biol Pharm Bull 35:91-97
34. Parkhouse WS, McKenzie DC, Hochachka PW, Ovalle WK (1985) Buffering capacity of deproteinized human vastus lateralis muscle. J Appl Physiol 58:14-17
35. Penafiel R, Ruzafa C, Monserrat F, Cremades A (2004) Gender-related differences in carnosine, anserine and lysine content of murine skeletal muscle. Amino Acids 26:53-58
36. Pierno S, Liantonio A, Camerino GM, De BM, Cannone M, Gramegna G, Scaramuzzi A, Simonetti S, Nicchia GP, Basco D, Svelto M, Desaphy JF, Camerino DC (2012) Potential benefits of taurine in the prevention of skeletal muscle impairment induced by disuse in the hindlimb-unloaded rat. Amino Acids 43:431-445
37. Tallon MJ, Harris RC, Boobis LH, Fallowfield JL, Wise JA (2005) The carnosine content of vastus lateralis is elevated in resistance-trained bodybuilders. J Strength Cond Res 19:725-729
38. Teufel M, Saudek V, Ledig JP, Bernhardt A, Boularand S, Carreau A, Cairns NJ, Carter C, Cowley DJ, Duverger D, Ganzhorn AJ, Guenet C, Heintzelmann B, Laucher V, Sauvage C, Smirnova T (2003) Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase. J Biol Chem 278:6521-6531
39. Vanderschueren D, Vandenput L, Boonen S, Van HE, Swinnen JV, Bouillon R (2000) An aged rat model of partial androgen deficiency: prevention of both loss of bone and lean body mass by low-dose androgen replacement. Endocrinology 141:1642-1647