Effects of aging, antiaging calorie restriction and in vivo stimulation of autophagy on the urinary excretion of 8OHdG in male Sprague-Dawley rats

Age

Volumn 35, Issue 2, 2013, Pages 261-270

  Donati, Alessio ^a   Cavallini, Gabriella ^a   Bergamini, Ettore ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

8OHdG; Antilipolytic drugs; Autophagy; Caloric restriction; Urine

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; EVEROLIMUS; MITOCHONDRIAL DNA;

AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOPHAGY; CALORIC RESTRICTION; CONTROLLED STUDY; DIET RESTRICTION; EX VIVO STUDY; IN VITRO STUDY; LIVER; LIVER CELL; MALE; NONHUMAN; PROTEIN DEGRADATION; RAT; URINALYSIS; URINARY EXCRETION;

AGING; ANALYSIS OF VARIANCE; ANIMALS; AUTOPHAGY; CALORIC RESTRICTION; DEOXYGUANOSINE; HYPOLIPIDEMIC AGENTS; LIVER; MALE; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; SIROLIMUS;

EID: 84880570394     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-011-9346-x     Document Type: Article

References (44)

1. Bergamini E, Gori Z (1995) Towards an understanding of the biological mechanism of dietary restriction: a signal transduction theory of aging. Aging Clin Exp Res 7:473-475
2. Bergamini E, Del Roso A, Fierabracci V, Gori Z, Masiello P, Masini M, Pollera M (1993) A new method for the investigation of endocrine-regulated autophagy and protein degradation in rat liver. Exp Mol Pathol 59:13-26
3. Bergamini E, Cavallini G, Donati A, Gori Z (2004) The role of macroautophagy in the ageing process, anti-ageing intervention and age-associated diseases. Int J Biochem Cell Biol 36(12):2392-2404
4. Bergamini E, Cavallini G, Donati A, Gori Z (2007) The role of autophagy in aging: its essential part in the anti-aging mechanism of caloric restriction. Ann N Y Acad Sci 1114:69-78
5. Blommaart EF, Luiken JJ, Blommaart PJ, van Woerkom GM, Meijer AJ (1995) Phosphorylation of ribosomal protein S6 is inhibitory for autophagy in isolated rat hepatocytes. J Biol Chem 270(5):2320-2326
6. Bohr VA (2002) Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cells. Free Radic Biol Med 32(9):804-812
7. Boulay A, Zumstein-Mecker S, Stephan C, Beuvink I, Zilbermann F, Haller R, Tobler S, Heusser C, O'Reilly T, Stolz B, Marti A, Thomas G, Lane HA (2004) Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells. Cancer Res 64(1):252-261
8. Burtis CA, Ashwood ER, Bruns DE (2009) Tietz textbook of clinical chemistry and molecular diagnostic, 4th edn. Elsevier, St. Louis
9. Cavallini G, Donati A, Taddei M, Bergamini E (2007) Evidence for selective mitochondrial autophagy and failure in aging. Autophagy 3(1):26-27
10. Cooke MS, Olinski R, Loft S, European Standards Committee on Urinary (DNA) Lesion Analysis (2008) Measurement and meaning of oxidatively modified DNA lesions in urine. Cancer Epidemiol Biomark Prev 17(1):3-14
11. Del Roso A, Vittorini S, Cavallini G, Donati A, Gori Z, Masini M, Pollera M, Bergamini E (2003) Ageing-related changes in the in vivo function of rat liver macroautophagy and proteolysis. Exp Gerontol 38(5):519-527
12. Donati A (2006) The involvement of macroautophagy in aging and anti-aging interventions. Mol Aspects Med 27(5-6):455-470
13. Donati A, Taddei M, Cavallini G, Bergamini E (2006) Stimulation of macroautophagy can rescue older cells from 8-OHdG mtDNA accumulation: a safe and easy way to meet goals in the SENS agenda. Rejuvenation Res 9(3):408-412
14. Donati A, Ventruti A, Cavallini G, Masini M, Vittorini S, Chantret I, Codogno P, Bergamini E (2008) In vivo effect of an antilipolytic drug (3,5'-dimethylpyrazole) on autophagic proteolysis and autophagy-related gene expression in rat liver. Biochem Biophys Res Commun 366(3):786-792
15. Donati A, Cavallini G, Bergamini E (2009) Methods for inducing and monitoring liver autophagy relative to aging and antiaging caloric restriction in rats. Methods Enzymol 452:441-455
16. Evans MD, Saparbaev M, Cooke MS (2010) DNA repair and the origins of urinary oxidized 2'-deoxyribonucleosides. Mutagenesis 25(5):433-442
17. Feuers RJ, Weindruch R, Hart RW (1993) Caloric restriction, aging, and antioxidant enzymes. Mutat Res 295(4-6):191-200
18. Fraga CG, Shigenaga MK, Park JW, Degan P, Ames BN (1990) Oxidative damage to DNA during aging: 8-hydroxy-2-deoxyguanosine in rat organ DNA and urine. Proc Natl Acad Sci U S A 7:4533-4537
19. Gruber J, Schaffer S, Halliwell B (2008) The mitochondrial free radical theory of ageing - where do we stand? Front Biosci 13:6554-6579
20. Hamilton ML, Van Remmen H, Drake JA, Yang H, Guo ZM, Kewitt K, Walter CA, Richardson A (2001) Does oxidative damage to DNA increase with age? Proc Natl Acad Sci U S A 98(18):10469-10474
21. Hartford CM, Ratain MJ (2007) Rapamycin: something old, something new, sometimes borrowed and now renewed. Clin Pharmacol Ther 82(4):381-388
22. Hofer T, Fontana L, Anton SD, Weiss EP, Villareal D, Malayappan B, Leeuwenburgh C (2008) Long-term effects of caloric restriction or exercise on DNA and RNA oxidation levels in white blood cells and urine in humans. Rejuvenation Res 11(4):793-799
23. Jin S (2006) Autophagy, mitochondrial quality control, and oncogenesis. Autophagy 2(2):80-84
24. Kim J, Kundu M, Viollet B, Guan KL (2011) AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 13(2):132-141
25. Korolchuk VI, Saiki S, Lichtenberg M, Siddiqi FH, Roberts EA, Imarisio S, Jahreiss L, Sarkar S, Futter M, Menzies FM, O'Kane CJ, Deretic V, Rubinsztein DC (2011) Lysosomal positioning coordinates cellular nutrient responses. Nat Cell Biol 13(4):453-460
26. Loft S, Vistisen K, Ewertz M, Tjonneland A, Overvad K, Poulsen HE (1992) Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans: influence of smoking, gender and body mass index. Carcinogenesis 13:2241-2247
27. Loft S, Velthuis-te Wierik EJ, van den Berg H, Poulsen HE (1995) Energy restriction and oxidative DNA damage in humans. Cancer Epidemiol Biomark Prev 4(5):515-519
28. Masoro EJ (2009) Caloric restriction-induced life extension of rats and mice: a critique of proposed mechanisms. Biochim Biophys Acta 1790(10):1040-1048
29. McCarter R, Masoro EJ, Yu BP (1985) Does food restriction retard aging by reducing the metabolic rate? Am J Physiol 248:E488-E490
30. Mizushima N (2009) Physiological functions of autophagy. Curr Top Microbiol Immunol 335:71-84
31. Mortimore GE, Mondon CE (1970) Inhibition by insulin of valine turnover in liver. Evidence for a general control of proteolysis. J Biol Chem 245(9):2375-2383
32. Mortimore GE, Pösö AR (1987) Intracellular protein catabolism and its control during nutrient deprivation and supply. Annu Rev Nutr 7:539-564
33. Nakamoto H, Kaneko T, Tahara S, Hayashi E, Naito H, Radak Z, Goto S (2007) Regular exercise reduces 8-oxodG in the nuclear and mitochondrial DNA and modulates the DNA repair activity in the liver of old rats. Exp Gerontol 42(4):287-295
34. Pfeifer U (1978) Inhibition by insulin of the formation of autophagic vacuoles in rat liver. A morphometric approach to the kinetics of intracellular degradation by autophagy. J Cell Biol 78:152-167
35. Prieme H, Loft S, Klarlund M, Gronbaek K, Tonnesen P, Poulsen HE (1998) Effect of smoking cessation on oxidative DNA modification estimated by 8-oxo-7,8-dihydro-2- deoxyguanosine excretion. Carcinogenesis 19:347-351
36. Richter C, Park JW, Ames BN (1988) Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc Natl Acad Sci U S A 85(17):6465-7
37. Simic MG, Bergtold DS (1991) Dietary modulation of DNA damage in human. Mutat Res 250(1-2):17-24
38. Sohal RS, Weindruch R (1996) Oxidative stress, caloric restriction, and aging. Science 273(5271):59-63
39. Sohal RS, Agarwal S, Candas M, Forster MJ, Lal H (1994) Effect of age and caloric restriction on DNA oxidative damage in different tissues of C57BL/6 mice. Mech Ageing Dev 76(2-3):215-224
40. Terman A, Kurz T, Navratil M, Arriaga EA, Brunk UT (2010) Mitochondrial turnover and aging of long-lived postmitotic cells: the mitochondrial-lysosomal axis theory of aging. Antioxid Redox Signal 12:503-535
41. Unnikrishnan A, Lucente LV, Richardson A (2007) Caloric restriction and genomic stability. Nucleic Acids Res 35(22):7485-7496
42. van Zutphen T, Veenhuis M, van der Klei IJ (2011) Damaged peroxisomes are subject to rapid autophagic degradation in the yeast Hansenula polymorpha. Autophagy 7(8):863-872
43. Verhagen H, Poulsen HE, Loft S, van Poppel G, Willems MI, van Bladeren PJ (1995) Reduction of oxidative DNA-damage in humans by Brussels sprouts. Carcinogenesis 16:969-970
44. Wu LL, Chiou CC, Chang PY, Wu JT (2004) Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics. Clin Chim Acta 339(1-2):1-9