PLGA nanoparticle entrapped killed porcine reproductive and respiratory syndrome virus vaccine helps in viral clearance in pigs

Veterinary Microbiology

Volumn 166, Issue 1-2, 2013, Pages 47-58

  Dwivedi, Varun ^a   Manickam, Cordelia ^a,b   Binjawadagi, Basavaraj ^a,b   Renukaradhya, Gourapura J ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Killed PRRSV vaccine; Mucosal immune response; PLGA nanoparticles; Protection; PRRS virus

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; NANOPARTICLE; NEUTRALIZING ANTIBODY; POLYGLYCOLIC ACID; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME VIRUS VACCINE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VIRUS VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY TITER; ARTERIVIRUS; ARTICLE; BLOOD; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; IMMUNE RESPONSE; LUNG; LUNG HOMOGENATE; MONONUCLEAR CELL; NONHUMAN; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; REGULATORY T LYMPHOCYTE; SWINE; VIRAL CLEARANCE; VIREMIA;

KILLED PRRSV VACCINE; MUCOSAL IMMUNE RESPONSE; PLGA NANOPARTICLES; PROTECTION; PRRS VIRUS;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTIBODIES, VIRAL; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; LACTIC ACID; LUNG; NANOPARTICLES; POLYGLYCOLIC ACID; PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME; PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SUS SCROFA; SWINE; TRANSFORMING GROWTH FACTOR BETA; VACCINES, INACTIVATED; VIRAL VACCINES;

PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS; SUIDAE; SUS;

EID: 84880510963     PISSN: 03781135     EISSN: 18732542     Source Type: Journal    
DOI: 10.1016/j.vetmic.2013.04.029     Document Type: Article

References (61)

1. Albina E., Carrat C., Charley B. Interferon-alpha response to swine arterivirus (PoAV), the porcine reproductive and respiratory syndrome virus. J. Interferon Cytokine Res. 1998, 18:485-490.
2. Anderson K.G., Sung H., Skon C.N., Lefrancois L., Deisinger A., Vezys V., Masopust D. Cutting edge: intravascular staining redefines lung CD8 T cell responses. J. Immunol. 2012, 189:2702-2706.
3. Baker R.B., Yu W., Fuentes M., Johnson C.R., Peterson L., Rossow K., Daniels C.S., Daniels A.M., Polson D., Murtaugh M.P. Prairie dog (Cynomys ludovicianus) is not a host for porcine reproductive and respiratory syndrome virus. J. Swine Health. Prod. 2007, 15:22-29.
4. Barbe F., Atanasova K., Van Reeth K. Cytokines and acute phase proteins associated with acute swine influenza infection in pigs. Vet. J. 2011, 187:48-53.
5. + T cells. Viral Immunol. 2004, 17:25-37.
6. Cao X., Schoichet M.S. Delivering neuroactive molecules from biodegradable microspheres for application in central nervous system disorders. Biomaterials 1999, 20:329-339.
7. Charerntantanakul W. Adjuvants for porcine reproductive and respiratory syndrome virus vaccines. Vet. Immunol. Immunopathol. 2009, 129:1-13.
8. Charerntantanakul W., Platt R., Roth J.A. Effects of porcine reproductive and respiratory syndrome virus-infected antigen-presenting cells on T cell activation and antiviral cytokine production. Viral Immunol. 2006, 19:646-661.
9. Christopher-Hennings J., Holler L.D., Benfield D.A., Nelson E.A. Detection and duration of porcine reproductive and respiratory syndrome virus in semen, serum, peripheral blood mononuclear cells, and tissues from Yorkshire, Hampshire, and Landrace boars. J. Vet. Diagn. Invest. 2001, 13:133-142.
10. Cose S., Brammer C., Khanna K.M., Masopust D., Lefrancois L. Evidence that a significant number of naive T cells enter non-lymphoid organs as part of a normal migratory pathway. Eur. J. Immunol. 2006, 36:1423-1433.
11. Diaz I., Darwich L., Pappaterra G., Pujols J., Mateu E. Immune responses of pigs after experimental infection with a European strain of Porcine reproductive and respiratory syndrome virus. J. Gen. Virol. 2005, 86:1943-1951.
12. Didierlaurent A., Goulding J., Hussell T. The impact of successive infections on the lung microenvironment. Immunology 2007, 122:457-465.
13. Done S.H., Paton D.J., White M.E. Porcine reproductive and respiratory syndrome (PRRS): a review, with emphasis on pathological, virological and diagnostic aspects. Br. Vet. J. 1996, 152:153-174.
14. Duncan R. Nanomedicine gets clinical. Mater. Today 2005, 8:16-17.
15. Dwivedi V., Manickam C., Binjawadagi B., Linhares D., Murtaugh M.P., Renukaradhya G.J. Evaluation of immune responses to porcine reproductive and respiratory syndrome virus in pigs during early stage of infection under farm conditions. Virol. J. 2012, 9:45.
16. Dwivedi V., Manickam C., Patterson R., Dodson K., Murtaugh M., Torrelles J.B., Schlesinger L.S., Renukaradhya G.J. Cross-protective immunity to porcine reproductive and respiratory syndrome virus by intranasal delivery of a live virus vaccine with a potent adjuvant. Vaccine 2011, 29:4058-4066.
17. Dwivedi V., Manickam C., Patterson R., Dodson K., Weeman M., Renukaradhya G.J. Intranasal delivery of whole cell lysate of Mycobacterium tuberculosis induces protective immune responses to a modified live porcine reproductive and respiratory syndrome virus vaccine in pigs. Vaccine 2011, 29:4067-4076.
18. Eldridge J.H., Gilley R.M., Staas J.K., Moldoveanu Z., Meulbroek J.A., Tice T.R. Biodegradable microspheres: vaccine delivery system for oral immunization. Curr. Top. Microbiol. Immunol. 1989, 146:59-66.
19. Foss D.L., Zilliox M.J., Meier W., Zuckermann F., Murtaugh M.P. Adjuvant danger signals increase the immune response to porcine reproductive and respiratory syndrome virus. Viral Immunol. 2002, 15:557-566.
20. Gomez-Laguna J., Salguero F.J., De Marco M.F., Pallares F.J., Bernabe A., Carrasco L. Changes in lymphocyte subsets and cytokines during European porcine reproductive and respiratory syndrome: increased expression of IL-12 and IL-10 and proliferation of CD4(-)CD8(high). Viral Immunol. 2009, 22:261-271.
21. Gupta R.K., Chang A.C., Siber G.R. Biodegradable polymer microspheres as vaccine adjuvants and delivery systems. Dev. Biol. Stand. 1998, 92:63-78.
22. Holmgren J., Czerkinsky C., Lycke N., Svennerholm A.M. Mucosal immunity: implications for vaccine development. Immunobiology 1992, 184:157-179.
23. Holtkamp, D., Kliebenstein, J., 2011. PRRS Costs Industry $664 Million Annually. Pork Checkoff Study, http://www.pork.org/News/1265/PRRSCostsIndustry664Million.aspx.
24. Inaba K., Inaba M., Naito M., Steinman R.M. Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guerin organisms, and sensitize mice to mycobacterial antigens in vivo. J. Exp. Med. 1993, 178:479-488.
25. Jaganathan K.S., Vyas S.P. Strong systemic and mucosal immune responses to surface-modified PLGA microspheres containing recombinant hepatitis B antigen administered intranasally. Vaccine 2006, 24:4201-4211.
26. Johnson C.R., Yu W., Murtaugh M.P. Cross-reactive antibody responses to nsp1 and nsp2 of Porcine reproductive and respiratory syndrome virus. J. Gen. Virol. 2007, 88:1184-1195.
27. Kaplan M.H., Sun Y.L., Hoey T., Grusby M.J. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 1996, 382:174-177.
28. Keffaber K.K. Reproductive failure of unknown etiology. Am. Assoc. Swine Pract. Newsl. 1989, 1:1-9.
29. Kim W.I., Lee D.S., Johnson W., Roof M., Cha S.H., Yoon K.J. Effect of genotypic and biotypic differences among PRRS viruses on the serologic assessment of pigs for virus infection. Vet. Microbiol. 2007, 123:1-14.
30. King A.M.Q., Lefkowitz E., Adams M.J., Carstens E.B. Virus taxonomy. Ninth Report of the International Committee on Taxonomy of Viruses International Union of Microbiological Societies, Virology Division 2011.
31. Li B., Fang L., Xu Z., Liu S., Gao J., Jiang Y., Chen H., Xiao S. Recombination in vaccine and circulating strains of porcine reproductive and respiratory syndrome viruses. Emerg. Infect. Dis. 2009, 15:2032-2035.
32. Liew F.Y., Russell S.M., Appleyard G., Brand C.M., Beale J. Cross-protection in mice infected with influenza A virus by the respiratory route is correlated with local IgA antibody rather than serum antibody or cytotoxic T cell reactivity. Eur. J. Immunol. 1984, 14:350-356.
33. Lopez O.J., Oliveira M.F., Garcia E.A., Kwon B.J., Doster A., Osorio F.A. Protection against porcine reproductive and respiratory syndrome virus (PRRSV) infection through passive transfer of PRRSV-neutralizing antibodies is dose dependent. Clin. Vaccine Immunol. 2007, 14:269-275.
34. Lopez O.J., Osorio F.A. Role of neutralizing antibodies in PRRSV protective immunity. Vet. Immunol. Immunopathol. 2004, 102:155-163.
35. Lu J.M., Wang X., Marin-Muller C., Wang H., Lin P.H., Yao Q., Chen C. Current advances in research and clinical applications of PLGA-based nanotechnology. Expert Rev. Mol. Diagn. 2009, 9:325-341.
36. Ma W., Chen M., Kaushal S., McElroy M., Zhang Y., Ozkan C., Bouvet M., Kruse C., Grotjahn D., Ichim T., Minev B. PLGA nanoparticle-mediated delivery of tumor antigenic peptides elicits effective immune responses. Int. J. Nanomed. 2012, 7:1475-1487.
37. Manickam C., Dwivedi V., Patterson R., Papenfuss T., Renukaradhya G.J. Porcine reproductive and respiratory syndrome virus induces pronounced immune modulatory responses at mucosal tissues in the parental vaccine strain VR2332 infected pigs. Vet. Microbiol. 2013, 162:68-77.
38. Mateu E., Diaz I. The challenge of PRRS immunology. Vet. J. 2008, 177:345-351.
39. McGhee J.R., Mestecky J., Dertzbaugh M.T., Eldridge J.H., Hirasawa M., Kiyono H. The mucosal immune system: from fundamental concepts to vaccine development. Vaccine 1992, 10:75-88.
40. Mengeling W.L., Clouser D.F., Vorwald A.C., Lager K.M. The potential role of genetic recombination in the evolution of new strains of porcine reproductive and respiratory syndrome virus (PRRSV). J Swine Health Prod. 2002, 10:273-275.
41. Mengeling W.L., Lager K.M., Vorwald A.C., Koehler K.J. Strain specificity of the immune response of pigs following vaccination with various strains of porcine reproductive and respiratory syndrome virus. Vet. Microbiol. 2003, 93:13-24.
42. Nielsen H.S., Oleksiewicz M.B., Forsberg R., Stadejek T., Botner A., Storgaard T. Reversion of a live porcine reproductive and respiratory syndrome virus vaccine investigated by parallel mutations. J. Gen. Virol. 2001, 82:1263-1272.
43. Ogra P.L., Karzon D.T. Distribution of poliovirus antibody in serum, nasopharynx and alimentary tract following segmental immunization of lower alimentary tract with poliovaccine. J. Immunol. 1969, 102:1423-1430.
44. Olin M.R., Hwa Choi K., Lee J., Molitor T.W. Gammadelta T-lymphocyte cytotoxic activity against Mycobacterium bovis analyzed by flow cytometry. J. Immunol. Methods 2005, 297:1-11.
45. Osorio F.A., Galeota J.A., Nelson E., Brodersen B., Doster A., Wills R., Zuckermann F., Laegreid W.W. Passive transfer of virus-specific antibodies confers protection against reproductive failure induced by a virulent strain of porcine reproductive and respiratory syndrome virus and establishes sterilizing immunity. Virology 2002, 302:9-20.
46. Panyam J., Labhasetwar V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv. Drug Deliv. Rev. 2003, 55:329-347.
47. Piras F., Bollard S., Laval F., Joisel F., Reynaud G., Charreyre C., Andreoni C., Juillard V. Porcine reproductive and respiratory syndrome (PRRS) virus-specific interferon-gamma(+) T-cell responses after PRRS virus infection or vaccination with an inactivated PRRS vaccine. Viral Immunol. 2005, 18:381-389.
48. Rajapaksa T.E., Bennett K.M., Hamer M., Lytle C., Rodgers V.G., Lo D.D. Intranasal M cell uptake of nanoparticles is independently influenced by targeting ligands and buffer ionic strength. J. Biol. Chem. 2010, 285:23739-23746.
49. Renukaradhya G.J., Alekseev K., Jung K., Fang Y., Saif L.J. Porcine reproductive and respiratory syndrome virus-induced immunosuppression exacerbates the inflammatory response to porcine respiratory coronavirus in pigs. Viral Immunol. 2010, 23:457-466.
50. Silva-Campa E., Cordoba L., Fraile L., Flores-Mendoza L., Montoya M., Hernandez J. European genotype of porcine reproductive and respiratory syndrome (PRRSV) infects monocyte-derived dendritic cells but does not induce Treg cells. Virology 2009, 396:264-271.
51. Silva-Campa E., Mata-Haro V., Mateu E., Hernandez J. Porcine reproductive and respiratory syndrome virus induces CD4(+)CD8(+)CD25(+)Foxp3(+) regulatory T cells (Tregs). Virology 2012, 430:73-80.
52. Singh M., Briones M., O'Hagan D.T. A novel bioadhesive intranasal delivery system for inactivated influenza vaccines. J. Control. Release 2001, 70:267-276.
53. Spiers I.D., Eyles J.E., Baillie L.W., Williamson E.D., Alpar H.O. Biodegradable microparticles with different release profiles: effect on the immune response after a single administration via intranasal and intramuscular routes. J. Pharm. Pharmacol. 2000, 52:1195-1201.
54. Suradhat S., Thanawongnuwech R., Poovorawan Y. Upregulation of IL-10 gene expression in porcine peripheral blood mononuclear cells by porcine reproductive and respiratory syndrome virus. J. Gen. Virol. 2003, 84:453-459.
55. Thomas C., Rawat A., Hope-Weeks L., Ahsan F. Aerosolized PLA and PLGA nanoparticles enhance humoral, mucosal and cytokine responses to hepatitis B vaccine. Mol. Pharm. 2011, 8:405-415.
56. Thomasin C., Corradin G., Men Y., Merkle H.P., Gander B. Tetanus toxoid and malaria antigen containing poly(lactide)/poly(lactide-co-glycolide) microspheres: importance of polymer degradation antigen release for immune response. J. Control. Release 1996, 41:131-145.
57. Unsoeld H., Pircher H. Complex memory T-cell phenotypes revealed by coexpression of CD62L and CCR7. J. Virol. 2005, 79:4510-4513.
58. Vanhee M., Delputte P.L., Delrue I., Geldhof M.F., Nauwynck H.J. Development of an experimental inactivated PRRSV vaccine that induces virus-neutralizing antibodies. Vet. Res. 2009, 40:63.
59. Waters W.R., Sacco R.E., Dorn A.D., Hontecillas R., Zuckermann F.A., Wannemuehler M.J. Systemic and mucosal immune responses of pigs to parenteral immunization with a pepsin-digested Serpulina hyodysenteriae bacterin. Vet. Immunol. Immunopathol. 1999, 69:75-87.
60. Xiao Z., Batista L., Dee S., Halbur P., Murtaugh M.P. The level of virus-specific T-cell and macrophage recruitment in porcine reproductive and respiratory syndrome virus infection in pigs is independent of virus load. J. Virol. 2004, 78:5923-5933.
61. Zuckermann F.A. Extrathymic CD4/CD8 double positive T cells. Vet. Immunol. Immunopathol. 1999, 72:55-66.