Biodegradable microparticles with different release profiles: Effect on the immune response after a single administration via intranasal and intramuscular routes

Journal of Pharmacy and Pharmacology

Volumn 52, Issue 10, 2000, Pages 1195-1201

  Spiers, I D ^a   Eyles, J E ^a   Baillie, L W J ^b   Williamson, E D ^b   Alpar, H O ^a  

^a ASTON UNIVERSITY   (United Kingdom)

^b DEFENCE SCIENCE AND TECHNOLOGY LABORATORY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BOVINE SERUM ALBUMIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; POLYGLACTIN; POLYLACTIDE; POLYMER; VACCINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIODEGRADATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG FORMULATION; DRUG RELEASE; ENCAPSULATION; EVAPORATION; EXTRACTION; FEMALE; IMMUNE RESPONSE; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; PROTEIN SECRETION;

EID: 0033755669     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357001777324     Document Type: Article

References (12)

1. Identification of some of the physico-chemical characteristics of microspheres which influence the induction of the immune response following mucosal delivery
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3. Double emulsion microencapsulation of proteins as model antigens using polylactide polymers: Effect of emulsifier on the microsphere characteristics and release kinetics
4. A comparative study on the immune responses to antigens in PLA and PHB microspheres
5. Intra nasal administration of polylactic acid microspheres co-encapsulated Yersinia pestis subunits confers protection from pneumonic plague in the mouse
6. Analysis of local and systemic immunological responses after intra-tracheal, intra-nasal and intra-muscular administration of microsphere co-encapsulated Yersinia pestis sub-vaccines
7. Generation of protective immune responses to plague by mucosal administration of microsphere coencapsulated recombinant subunits
8. Effects of antigen dose and immunisation regimens on antibody responses to a cytomegalovirus glycoprotein B subunit vaccine
9. Immunopotentiation and delivery systems for antigens for single-step immunisation: Recent trends and progress
10. Poly(lactide-co-glycolide) microparticles for the development of single-dose controlled-release vaccines
11. Measurement of protein using bicinchoninic acid
12. Studies on the co-encapsulation, release and integrity of two subunit antigens: rV and rF1 from Yersinia pestis