Baicalein reduces β-amyloid and promotes nonamyloidogenic amyloid precursor protein processing in an Alzheimer's disease transgenic mouse model

Journal of Neuroscience Research

Volumn 91, Issue 9, 2013, Pages 1239-1246

  Zhang, She Qing ^a,b   Obregon, Demian ^b   Ehrhart, Jared ^b   Deng, Juan ^b   Tian, Jun ^b   Hou, Huayan ^b   Giunta, Brian ^b   Sawmiller, Darrell ^b   Tan, Jun ^b  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

amyloid; Alzheimer's disease; Baicalein; Flavonoid; GABA; SAPP

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALPHA SECRETASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BAICALEIN; BICUCULLINE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN HOMOGENATE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE OVEREXPRESSION; MAZE TEST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; RAT; TRANSGENIC MOUSE; WESTERN BLOTTING; WILD TYPE;

Β-AMYLOID; ALZHEIMER'S DISEASE; BAICALEIN; FLAVONOID; GABA; SAPPΑ;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANTIOXIDANTS; BICUCULLINE; CHO CELLS; CRICETULUS; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLAVANONES; GABA-A RECEPTOR ANTAGONISTS; GENE EXPRESSION REGULATION; HUMANS; MAZE LEARNING; MICE; MICE, TRANSGENIC; MUTATION; TRANSFECTION;

EID: 84880510941     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.23244     Document Type: Article

References (30)

1. Arendash GW, Gordon M, Diamond DM, Austin LA, Hatcher JM, Jantzen P, DiCarlo G, Wilcock D, Morgan D. 2001. Behavioral assessment of Alzheimer's transgenic mice following long-term Abeta vaccination: task specificity and correlations between Abeta deposition and spatial memory. DNA Cell Biol 20:737-744.
2. Behrens CJ, van den Boom LP, Heinemann U. 2007. Effects of the GABAA receptor antagonists bicuculline and gabazine on stimulus-induced sharp wave-ripple complexes in adult rat hippocampus in vitro. Eur J Neurosci 25:2170-2181.
3. Dawson GR, Maubach KA, Collinson N, Cobain M, Everitt BJ, MacLeod AM, Choudhury HI, McDonald LM, Pillai G, Rycroft W, Smith AJ, Sternfeld F, Tattersall FD, Wafford KA, Reynolds DS, Seabrook GR, Atack JR. 2006. An inverse agonist selective for alpha 5 subunit-containing GABAA receptors enhances cognition. J Pharmacol Exp Ther 316:1335-1345.
4. de Carvalho RS, Duarte FS, de Lima TC. 2011. Involvement of GABAergic non-benzodiazepine sites in the anxiolytic-like and sedative effects of the flavonoid baicalein in mice. Behav Brain Res 221:75-82.
5. Gu Z, Zhong P, Yan Z. 2003. Activation of muscarinic receptors inhibits beta-amyloid peptide-induced signaling in cortical slices. J Biol Chem 278:17546-17556.
6. Hahn S, Bruning T, Ness J, Czirr E, Baches S, Gijsen H, Korth C, Pietrzik CU, Bulic B, Weggen S. 2011. Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to gamma-secretase modulators regardless of their potency and structure. J Neurochem 116:385-395.
7. Hardy JA, Higgins GA. 1992. Alzheimer's disease: the amyloid cascade hypothesis. Science 256:184-185.
8. Hardy J, Selkoe DJ. 2002. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297:353-356.
9. Hardy J, Duff K, Hardy KG, Perez-Tur J, Hutton M. 1998. Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau. Nat Neurosci 1:355-358.
10. Heo HJ, Kim DO, Choi SJ, Shin DH, Lee CY. 2004. Potent Inhibitory effect of flavonoids in Scutellaria baicalensis on amyloid beta protein-induced neurotoxicity. J Agric Food Chem 52:4128-4132.
11. Heo H, Shin Y, Cho W, Choi Y, Kim H, Kwon YK. 2009. Memory improvement in ibotenic acid induced model rats by extracts of Scutellaria baicalensis. J Ethnopharmacol 122:20-27.
12. Jianjun J, Huiru D. 2008. Preparation of high-purity baicalein from Scutellaria baicalensis Georgi. Nat Prod Res 22:1410-1412.
13. Lee BY, Ban JY, Seong YH. 2005. Chronic stimulation of GABAA receptor with muscimol reduces amyloid beta protein (25-35)-induced neurotoxicity in cultured rat cortical cells. Neurosci Res 52:347-356.
14. Liu C, Wu JL, Gu J, Xiong Z, Wang F, Wang JZ, Wanu W, Chen JG. 2007. Baicalein improves cognitive deficits induced by chronic cerebral hypoperfusion in rats. Pharmacol Biochem Behav 86:423-430.
15. Liu YH, Giunta B, Zhou HD, Tan J, Wang YJ. 2012. Immunotherapy for Alzheimer disease-the challenge of adverse effects. Nat Rev Neurol 8:465-469.
16. Lu JH, Ardah MT, Durairajan SSK, Liu LF, Xie LX, Fong WFD, Hasan MY, Huang JD, El-Agnaf OMA, Li M. 2011. Baicalein inhibits formation of alpha-synuclein oligomers within living cells and prevents A beta peptide fibrillation and oligomerisation. Chembiochem 12:615-624.
17. Marcade M, Bourdin J, Loiseau N, Peillon H, Rayer A, Drouin D, Schweighoffer F, Desire L. 2008. Etazolate, a neuroprotective drug linking GABAA receptor pharmacology to amyloid precursor protein processing. J Neurochem 106:392-404.
18. Mattson MP, Cheng B, Culwell AR, Esch FS, Lieberburg I, Rydel RE. 1993. Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein. Neuron 10:243-254.
19. Obregon DF, Rezai-Zadeh K, Bai Y, Sun N, Hou H, Ehrhart J, Zeng J, Mori T, Arendash GW, Shytle D, Town T, Tan J. 2006. ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced α-secretase cleavage of amyloid precursor protein. J Biol Chem 281:16419-16427.
20. Obregon D, Hou HY, Deng J, Giunta B, Tian J, Darlington D, Shahaduzzaman M, Zhu YY, Mori T, Mattson MP, Tan J. 2012. Soluble amyloid precursor protein-alpha modulates beta-secretase activity and amyloid-beta generation. Nat Commun 3:777.
21. Panza F, Frisardi V, Imbimbo BP, Capurso C, Logroscino G, Sancarlo D, Seripa D, Vendemiale G, Pilotto A, Solfrizzi V. 2010. Review: gamma-secretase inhibitors for the treatment of Alzheimer's disease: the current state. CNS Neurosci Ther 16:272-284.
22. Rezai-Zadeh K, Shytle D, Sun N, Mori T, Hou H, Jeanniton D, Ehrhart J, Townsend K, Zeng J, Morgan D, Hardy J, Town T, Tan J. 2005. Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice. J Neurosci 25:8807-8814.
23. Ring S, Weyer SW, Kilian SB, Waldron E, Pietrzik CU, Filippov MA, Herms J, Buchholz C, Eckman CB, Korte M, Wolfer DP, Muller UC. 2007. The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice. J Neurosci 27:7817-7826.
24. Roychaudhuri R, Yang M, Hoshi MM, Teplow DB. 2009. Amyloid beta-protein assembly and Alzheimer disease. J Biol Chem 284:4749-4753.
25. Tao YH, Jiang DY, Xu HB, Yang XL. 2008. Inhibitory effect of Erigeron breviscapus extract and its flavonoid components on GABA shunt enzymes. Phytomedicine 15:92-97.
26. Turner PR, O'Connor K, Tate WP, Abraham WC. 2003. Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. Prog Neurobiol 70:1-32.
27. Wang SY, Wang HH, Chi CW, Chen CF, Liao JF. 2004. Effects of baicalein on beta-amyloid peptide-(25-35)-induced amnesia in mice. Eur J Pharmacol 506:55-61.
28. Yankner BA, Lu T. 2009. Amyloid beta-protein toxicity and the pathogenesis of Alzheimer disease. J Biol Chem 284:4755-4759.
29. Zhu M, Rajamani S, Kaylor J, Han S, Zhou F, Fink AL. 2004. The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils. J Biol Chem 279:26846-26857.
30. Zhu Y, Hou H, Rezai-Zadeh K, Giunta B, Ruscin A, Gemma C, Jin J, Dragicevic N, Bradshaw P, Rasool S, Glabe CG, Ehrhart J, Bickford P, Mori T, Obregon D, Town T, Tan J. 2011. CD45 deficiency drives amyloid-beta peptide oligomers and neuronal loss in Alzheimer's disease mice. J Neurosci 31:1355-1365.