메뉴 건너뛰기




Volumn 221, Issue 1, 2011, Pages 75-82

Involvement of GABAergic non-benzodiazepine sites in the anxiolytic-like and sedative effects of the flavonoid baicalein in mice

Author keywords

5 HT; Anxiety; Baicalin; Flavonoids; GABA; Sedation

Indexed keywords

BAICALEIN; BENZODIAZEPINE; DIAZEPAM; DIENPAX; FENCLONINE; FLUMAZEN; FLUMAZENIL; PENTETRAZOLE; PRASTERONE SULFATE; SEROTONIN; UNCLASSIFIED DRUG;

EID: 79952988173     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2011.02.038     Document Type: Article
Times cited : (82)

References (46)
  • 1
    • 0030740446 scopus 로고    scopus 로고
    • Effects of baicalein isolated from Scutellaria baicalensis on interleukin 1 beta- and tumor necrosis factor alpha-induced adhesion molecule expression in cultured human umbilical vein endothelial cells
    • Kimura Y., Matsushita N., Okuda H. Effects of baicalein isolated from Scutellaria baicalensis on interleukin 1 beta- and tumor necrosis factor alpha-induced adhesion molecule expression in cultured human umbilical vein endothelial cells. J Ethopharmacol 1997, 57:63-67.
    • (1997) J Ethopharmacol , vol.57 , pp. 63-67
    • Kimura, Y.1    Matsushita, N.2    Okuda, H.3
  • 2
    • 0036969504 scopus 로고    scopus 로고
    • Structure-activity relationships of flavonoids, isolated from Scutellaria baicalensis, binding to benzodiazepine site of GABA(A) receptor complex
    • Wang H., Hui K.M., Chen Y., Xu S., Wong J.T., Xue H. Structure-activity relationships of flavonoids, isolated from Scutellaria baicalensis, binding to benzodiazepine site of GABA(A) receptor complex. Planta Med 2002, 68(12):1059-1062.
    • (2002) Planta Med , vol.68 , Issue.12 , pp. 1059-1062
    • Wang, H.1    Hui, K.M.2    Chen, Y.3    Xu, S.4    Wong, J.T.5    Xue, H.6
  • 3
    • 0038464586 scopus 로고    scopus 로고
    • Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties
    • Bochorakova H., Paulova H., Slanina J., Musil P., Taborska E. Main flavonoids in the root of Scutellaria baicalensis cultivated in Europe and their comparative antiradical properties. Phytother Res 2003, 17(6):640-644.
    • (2003) Phytother Res , vol.17 , Issue.6 , pp. 640-644
    • Bochorakova, H.1    Paulova, H.2    Slanina, J.3    Musil, P.4    Taborska, E.5
  • 4
    • 3042559829 scopus 로고    scopus 로고
    • Potent inhibitory effect of flavonoids in Scutellaria baicalensis on amyloid beta protein-induced neurotoxicity
    • Heo H.J., Kim D.O., Choi S.J., Shin D.H., Lee C.Y. Potent inhibitory effect of flavonoids in Scutellaria baicalensis on amyloid beta protein-induced neurotoxicity. J Agric Food Chem 2004, 52(13):4128-4132.
    • (2004) J Agric Food Chem , vol.52 , Issue.13 , pp. 4128-4132
    • Heo, H.J.1    Kim, D.O.2    Choi, S.J.3    Shin, D.H.4    Lee, C.Y.5
  • 5
    • 0035371508 scopus 로고    scopus 로고
    • Wogonin, baicalin and baicalein inhibition of nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide
    • Chen Y.-C., Shen S.-C., Chen L.-G., Lee T.J.-F., Yang L.-L. Wogonin, baicalin and baicalein inhibition of nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide. Biochem Pharmacol 2001, 61:1417-1427.
    • (2001) Biochem Pharmacol , vol.61 , pp. 1417-1427
    • Chen, Y.-C.1    Shen, S.-C.2    Chen, L.-G.3    Lee, T.J.-F.4    Yang, L.-L.5
  • 6
    • 1642534342 scopus 로고    scopus 로고
    • Inhibition of nitric oxide/cyclic GMP-mediated relaxation by purified flavonoids, baicalin and baicalein, in rat aortic rings
    • Huang Y., Wong C.M., Lau C.-W., Yao X., Tsang S.Y., Su Y.L., et al. Inhibition of nitric oxide/cyclic GMP-mediated relaxation by purified flavonoids, baicalin and baicalein, in rat aortic rings. Biochem Pharmacol 2004, 67:787-794.
    • (2004) Biochem Pharmacol , vol.67 , pp. 787-794
    • Huang, Y.1    Wong, C.M.2    Lau, C.-W.3    Yao, X.4    Tsang, S.Y.5    Su, Y.L.6
  • 7
    • 0027742757 scopus 로고
    • Inhibitory effects of flavonoids on xanthine
    • Chang W.S., Lee Y.J., Lu F.J., Chiang H.C. Inhibitory effects of flavonoids on xanthine. Anticancer Res 1993, 13(6A):2165-2170.
    • (1993) Anticancer Res , vol.13 , Issue.6 A , pp. 2165-2170
    • Chang, W.S.1    Lee, Y.J.2    Lu, F.J.3    Chiang, H.C.4
  • 8
    • 0031736653 scopus 로고    scopus 로고
    • Baicalin and baicalein, constituents of an important medicinal plant, inhibit intracellular Ca2+ elevation by reducing phospholipase C activity in C6 rat glioma cells
    • Kyo R., Nakahata N., Sakakibara I., Kubo M., Ohizumi Y. Baicalin and baicalein, constituents of an important medicinal plant, inhibit intracellular Ca2+ elevation by reducing phospholipase C activity in C6 rat glioma cells. J Pharm Pharmacol 1998, 50(10):1179-1182.
    • (1998) J Pharm Pharmacol , vol.50 , Issue.10 , pp. 1179-1182
    • Kyo, R.1    Nakahata, N.2    Sakakibara, I.3    Kubo, M.4    Ohizumi, Y.5
  • 9
    • 0037454131 scopus 로고    scopus 로고
    • Anxiolytic-like effects of baicalein and baicalin in the Vogel conflict test in mice
    • Liao J.F., Hung W.Y., Chen C.F. Anxiolytic-like effects of baicalein and baicalin in the Vogel conflict test in mice. Eur J Pharmacol 2003, 464:141-146.
    • (2003) Eur J Pharmacol , vol.464 , pp. 141-146
    • Liao, J.F.1    Hung, W.Y.2    Chen, C.F.3
  • 10
    • 9644268831 scopus 로고    scopus 로고
    • Effects of baicalein on β-amyloid peptide-(25-35)-induced amnesia in mice
    • Wang S.-Y., Wang H.-H., Chi C.-W., Chieh C.-F., Liao J.F. Effects of baicalein on β-amyloid peptide-(25-35)-induced amnesia in mice. Eur J Pharmacol 2004, 506:55-61.
    • (2004) Eur J Pharmacol , vol.506 , pp. 55-61
    • Wang, S.-Y.1    Wang, H.-H.2    Chi, C.-W.3    Chieh, C.-F.4    Liao, J.F.5
  • 11
    • 46149119392 scopus 로고    scopus 로고
    • Neuroprotective effect of baicalein against MPTP neurotoxicity: behavioral, biochemical and immunohistochemical profile
    • Cheng Y., He G., Mu X., Zhang T., Li X., Hu J., et al. Neuroprotective effect of baicalein against MPTP neurotoxicity: behavioral, biochemical and immunohistochemical profile. Neurosci Lett 2008, 441:16-20.
    • (2008) Neurosci Lett , vol.441 , pp. 16-20
    • Cheng, Y.1    He, G.2    Mu, X.3    Zhang, T.4    Li, X.5    Hu, J.6
  • 12
    • 67349270928 scopus 로고    scopus 로고
    • Baicalein exerts neuroprotective effects in 6- hydroxydopamine-induced experimental parkinsonism in vivo and in vitro
    • Mu X., He G., Cheng Y., Li X., Xu B., Du G. Baicalein exerts neuroprotective effects in 6- hydroxydopamine-induced experimental parkinsonism in vivo and in vitro. Pharmacol Biochem Behav 2009, 92:642-648.
    • (2009) Pharmacol Biochem Behav , vol.92 , pp. 642-648
    • Mu, X.1    He, G.2    Cheng, Y.3    Li, X.4    Xu, B.5    Du, G.6
  • 13
    • 54049111741 scopus 로고    scopus 로고
    • GABAA receptor subtype selectivity underlying selective anxiolytic effect of baicalin
    • Wang F., Zhiwen X., Ren L., Tsang S.Y., Xue H. GABAA receptor subtype selectivity underlying selective anxiolytic effect of baicalin. Neuropharmacology 2008, 55:1231-1237.
    • (2008) Neuropharmacology , vol.55 , pp. 1231-1237
    • Wang, F.1    Zhiwen, X.2    Ren, L.3    Tsang, S.Y.4    Xue, H.5
  • 14
    • 33644501473 scopus 로고    scopus 로고
    • Anxiolytic-like effect of baicalin and its additivity with other anxiolytic
    • Xu Z., Wang F., Tsang S.Y., Ho K.H., Zheng H., Yuen C.T., et al. Anxiolytic-like effect of baicalin and its additivity with other anxiolytic. Planta Med 2006, 72(2):189-192.
    • (2006) Planta Med , vol.72 , Issue.2 , pp. 189-192
    • Xu, Z.1    Wang, F.2    Tsang, S.Y.3    Ho, K.H.4    Zheng, H.5    Yuen, C.T.6
  • 15
    • 34249297623 scopus 로고    scopus 로고
    • Mechanistic study on the intestinal absorption and disposition of baicalein
    • Zhang L., Lin G., Kovács B., Jani M., Krajcsi P., Zuo Z. Mechanistic study on the intestinal absorption and disposition of baicalein. Eur J Pharm Sci 2007, 31:221-231.
    • (2007) Eur J Pharm Sci , vol.31 , pp. 221-231
    • Zhang, L.1    Lin, G.2    Kovács, B.3    Jani, M.4    Krajcsi, P.5    Zuo, Z.6
  • 17
    • 0030007556 scopus 로고    scopus 로고
    • Ovarian steroids modify the behavioral and neurochemical responses of the central benzodiazepine receptor
    • Bitran D., Dowd J.A. Ovarian steroids modify the behavioral and neurochemical responses of the central benzodiazepine receptor. Psychopharmacology 1996, 125:65-75.
    • (1996) Psychopharmacology , vol.125 , pp. 65-75
    • Bitran, D.1    Dowd, J.A.2
  • 18
    • 0023011642 scopus 로고
    • Intracerebroventricular injections in mice. Some methodological refinements
    • Laursen S.E., Belknap J.K. Intracerebroventricular injections in mice. Some methodological refinements. J Pharmacol Methods 1986, 16(4):355-357.
    • (1986) J Pharmacol Methods , vol.16 , Issue.4 , pp. 355-357
    • Laursen, S.E.1    Belknap, J.K.2
  • 19
    • 43149095155 scopus 로고    scopus 로고
    • Anticonvulsant and anxiolytic-like effects of compounds isolated from Polygala sabulosa (Polygalaceae) in rodents: in vitro and in vivo interactions with benzodiazepine binding sites
    • Duarte F.S., Marder M., Hoeller A.A., Duzzioni M., Mendes B.G., Pizzolatti M.G., et al. Anticonvulsant and anxiolytic-like effects of compounds isolated from Polygala sabulosa (Polygalaceae) in rodents: in vitro and in vivo interactions with benzodiazepine binding sites. Psychopharmacology 2008, 97:351-360.
    • (2008) Psychopharmacology , vol.97 , pp. 351-360
    • Duarte, F.S.1    Marder, M.2    Hoeller, A.A.3    Duzzioni, M.4    Mendes, B.G.5    Pizzolatti, M.G.6
  • 20
    • 0032564654 scopus 로고    scopus 로고
    • Naloxone-induced changes in tachykinin NK3 receptor modulation of experimental anxiety in mice
    • Ribeiro S.J., De Lima T.C.M. Naloxone-induced changes in tachykinin NK3 receptor modulation of experimental anxiety in mice. Neurosci Lett 1998, 258:155-158.
    • (1998) Neurosci Lett , vol.258 , pp. 155-158
    • Ribeiro, S.J.1    De Lima, T.C.M.2
  • 21
    • 21344474109 scopus 로고    scopus 로고
    • Evaluation of GABAergic neuroactive steroid 3α-hydroxy-5α-pregnane-20-one as a neurobiological substrate for the anti-anxiety effect of ethanol in rats
    • Hirani K., Sharma A.N., Jain N.S., Ugale R.R., Chopde C.T. Evaluation of GABAergic neuroactive steroid 3α-hydroxy-5α-pregnane-20-one as a neurobiological substrate for the anti-anxiety effect of ethanol in rats. Psychopharmacology 2005, 180:267-278.
    • (2005) Psychopharmacology , vol.180 , pp. 267-278
    • Hirani, K.1    Sharma, A.N.2    Jain, N.S.3    Ugale, R.R.4    Chopde, C.T.5
  • 23
    • 38749096307 scopus 로고    scopus 로고
    • Evidence for the involvement of the monoaminergic system in the antidepressant-like action of two 4-amine derivatives of 10,11-dihydro-5H-dibenzo [a,d] cycloheptane in mice evaluated in the tail suspension test
    • Duarte F.S., Lach G., Martins P.R.C., Romeiro G.A., De Lima T.C.M. Evidence for the involvement of the monoaminergic system in the antidepressant-like action of two 4-amine derivatives of 10,11-dihydro-5H-dibenzo [a,d] cycloheptane in mice evaluated in the tail suspension test. Prog Neuro-Psychopharmacol Biol Psychiatry 2008, 32:368-374.
    • (2008) Prog Neuro-Psychopharmacol Biol Psychiatry , vol.32 , pp. 368-374
    • Duarte, F.S.1    Lach, G.2    Martins, P.R.C.3    Romeiro, G.A.4    De Lima, T.C.M.5
  • 24
    • 47649119592 scopus 로고    scopus 로고
    • GABAA signalling is involved in N/OFQ anxiolytic-like effects but not in nocistatin anxiogenic-like action as evaluated in the mouse elevated plus maze
    • Gavioli E.C., Duarte F.S., Guerrini R., Calo G., Rae G.A., De Lima T.C.M. GABAA signalling is involved in N/OFQ anxiolytic-like effects but not in nocistatin anxiogenic-like action as evaluated in the mouse elevated plus maze. Peptides 2008, 29:1404-1412.
    • (2008) Peptides , vol.29 , pp. 1404-1412
    • Gavioli, E.C.1    Duarte, F.S.2    Guerrini, R.3    Calo, G.4    Rae, G.A.5    De Lima, T.C.M.6
  • 25
    • 79954629705 scopus 로고    scopus 로고
    • Avaliação dos efeitos centrais do extrato aquoso (EA) de Stachytarpheta cayennensis Vahl
    • M.Sc. Dissertation in Pharmacology, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil.
    • Vieira RA, 2001. Avaliação dos efeitos centrais do extrato aquoso (EA) de Stachytarpheta cayennensis Vahl. M.Sc. Dissertation in Pharmacology, Universidade Federal de Santa Catarina, Florianópolis, SC, Brasil.
    • (2001)
    • Vieira, R.A.1
  • 26
    • 0023255981 scopus 로고
    • The use of a plus-maze to measure anxiety in the mouse
    • Lister R.G. The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology 1987, 92:180-185.
    • (1987) Psychopharmacology , vol.92 , pp. 180-185
    • Lister, R.G.1
  • 27
    • 0002358097 scopus 로고
    • The elevated pluz-maze: pharmacology, methodology and ethology
    • Wiley, Chichester, S.J. Cooper, C.A. Hendrie (Eds.)
    • Rodgers R.J., Cole J.C. The elevated pluz-maze: pharmacology, methodology and ethology. Ethology and psychopharmacology 1994, 9-44. Wiley, Chichester. S.J. Cooper, C.A. Hendrie (Eds.).
    • (1994) Ethology and psychopharmacology , pp. 9-44
    • Rodgers, R.J.1    Cole, J.C.2
  • 28
    • 79954628900 scopus 로고
    • Choosing a statistic
    • W.H. Freeman and Company, San Francisco, J. Freedman, G. Lindzey, R.F. Thompson (Eds.)
    • Phillips D.S. Choosing a statistic. Basic statistics for health sciene students 1978, 128-130. W.H. Freeman and Company, San Francisco. J. Freedman, G. Lindzey, R.F. Thompson (Eds.).
    • (1978) Basic statistics for health sciene students , pp. 128-130
    • Phillips, D.S.1
  • 29
    • 0032816675 scopus 로고    scopus 로고
    • Hormesis: a highly generalizable and reproducible phenomenon with important implications for risk assessment
    • Calabrese E.J., Baldwin L.A., Holland C.D. Hormesis: a highly generalizable and reproducible phenomenon with important implications for risk assessment. Risk Anal 1999, 19(2):261-281.
    • (1999) Risk Anal , vol.19 , Issue.2 , pp. 261-281
    • Calabrese, E.J.1    Baldwin, L.A.2    Holland, C.D.3
  • 30
    • 0141564850 scopus 로고    scopus 로고
    • Biphasic action of midazolam on GABAA receptor-mediated responses in rat sacral dorsal commissural neurons
    • Wang D.S., Lu S.Y., Hong Z., Zhu H.L. Biphasic action of midazolam on GABAA receptor-mediated responses in rat sacral dorsal commissural neurons. Biochem Biophys Res Commun 2003, 309(4):893-899.
    • (2003) Biochem Biophys Res Commun , vol.309 , Issue.4 , pp. 893-899
    • Wang, D.S.1    Lu, S.Y.2    Hong, Z.3    Zhu, H.L.4
  • 32
    • 0029054098 scopus 로고
    • Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects
    • Viola H., Wasowski C., Levi de Stein M., Wolfman C., Silveira R., Dajas F., et al. Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. Planta Med 1995, 61(3):213-216.
    • (1995) Planta Med , vol.61 , Issue.3 , pp. 213-216
    • Viola, H.1    Wasowski, C.2    Levi de Stein, M.3    Wolfman, C.4    Silveira, R.5    Dajas, F.6
  • 33
    • 0027976019 scopus 로고
    • Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora coerulea
    • Wolfman C., Viola H., Paladini A., Dajas F., Medina J.H. Possible anxiolytic effects of chrysin, a central benzodiazepine receptor ligand isolated from Passiflora coerulea. Pharmacol Biochem Behav 1994, 47(1):1-4.
    • (1994) Pharmacol Biochem Behav , vol.47 , Issue.1 , pp. 1-4
    • Wolfman, C.1    Viola, H.2    Paladini, A.3    Dajas, F.4    Medina, J.H.5
  • 34
    • 17444424615 scopus 로고    scopus 로고
    • Synergistic interaction between hesperidin, a natural flavonoid, and diazepam
    • Fernández S.P., Wasowski C., Paladini A.C., Marder M. Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. Eur J Pharmacol 2005, 512:189-198.
    • (2005) Eur J Pharmacol , vol.512 , pp. 189-198
    • Fernández, S.P.1    Wasowski, C.2    Paladini, A.C.3    Marder, M.4
  • 35
    • 0034255092 scopus 로고    scopus 로고
    • Behavioral characterisation of the flavonoids apigenin and chrysin
    • Zanoli P., Avallone R., Baraldi M. Behavioral characterisation of the flavonoids apigenin and chrysin. Fitoterapia 2000, 71:117-123.
    • (2000) Fitoterapia , vol.71 , pp. 117-123
    • Zanoli, P.1    Avallone, R.2    Baraldi, M.3
  • 37
    • 21744447595 scopus 로고    scopus 로고
    • Neurosteroids: endogenous regulators of the GABAA receptor
    • Belelli D., Lambert J.J. Neurosteroids: endogenous regulators of the GABAA receptor. Nat Rev Neurosci 2005, 6:565-575.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 565-575
    • Belelli, D.1    Lambert, J.J.2
  • 38
    • 0031877378 scopus 로고    scopus 로고
    • Benzodiazepine binding site-interactive flavones from Scutellaria baicalensis root
    • Liao J.F., Wang H.H., Chen M.C., Chen C.C., Chen C.F. Benzodiazepine binding site-interactive flavones from Scutellaria baicalensis root. Planta Med 1998, 64(6):571-572.
    • (1998) Planta Med , vol.64 , Issue.6 , pp. 571-572
    • Liao, J.F.1    Wang, H.H.2    Chen, M.C.3    Chen, C.C.4    Chen, C.F.5
  • 39
    • 0030854871 scopus 로고    scopus 로고
    • Interactions of the neurosteroid dehydroepiandrosterone sulfate with the GABA(A) receptor complex reveals that it may act via the picrotoxin site
    • Souza A., Ticku M.K. Interactions of the neurosteroid dehydroepiandrosterone sulfate with the GABA(A) receptor complex reveals that it may act via the picrotoxin site. J Pharmacol Exp Ther 1997, 282:827-833.
    • (1997) J Pharmacol Exp Ther , vol.282 , pp. 827-833
    • Souza, A.1    Ticku, M.K.2
  • 40
    • 50949103149 scopus 로고    scopus 로고
    • Flavan-3-ol derivatives are positive modulators of GABAA receptors with higher efficacy for α2 subtype and anxiolytic action in mice
    • Fernández S.P., Mewett K.N., Hanrahan J.R., Chebib M., Johnston G.A.R. Flavan-3-ol derivatives are positive modulators of GABAA receptors with higher efficacy for α2 subtype and anxiolytic action in mice. Neuropharmacology 2008, 55(5):900-907.
    • (2008) Neuropharmacology , vol.55 , Issue.5 , pp. 900-907
    • Fernández, S.P.1    Mewett, K.N.2    Hanrahan, J.R.3    Chebib, M.4    Johnston, G.A.R.5
  • 41
    • 34249783909 scopus 로고    scopus 로고
    • Involvement of 5-HT1A and GABAA receptors in the anxiolytic-like effects of Cinnamomum cassia in mice
    • Yu H.-S., Lee S.-Y., Jang C.-G. Involvement of 5-HT1A and GABAA receptors in the anxiolytic-like effects of Cinnamomum cassia in mice. Pharmacol Biochem Behav 2007, 87:164-170.
    • (2007) Pharmacol Biochem Behav , vol.87 , pp. 164-170
    • Yu, H.-S.1    Lee, S.-Y.2    Jang, C.-G.3
  • 42
    • 0030782744 scopus 로고    scopus 로고
    • Anxiety, defence and the elevated plus-maze
    • Rodgers R.J., Dalvi A. Anxiety, defence and the elevated plus-maze. Neurosci Biobehav Rev 1997, 21(6):801-810.
    • (1997) Neurosci Biobehav Rev , vol.21 , Issue.6 , pp. 801-810
    • Rodgers, R.J.1    Dalvi, A.2
  • 43
    • 16244367134 scopus 로고    scopus 로고
    • Reversal of caffeine-induced anxiety by neurosteroid 3-alpha-hydroxy-5-alpha-pregnane-20-one in rats
    • Jain N.S., Hirani K., Chopde C.T. Reversal of caffeine-induced anxiety by neurosteroid 3-alpha-hydroxy-5-alpha-pregnane-20-one in rats. Neuropharmacology 2005, 48:627-638.
    • (2005) Neuropharmacology , vol.48 , pp. 627-638
    • Jain, N.S.1    Hirani, K.2    Chopde, C.T.3
  • 45
    • 0033056501 scopus 로고    scopus 로고
    • Behavioral effects of diazepam in the murine plus-maze: flumazenil antagonism of enhanced head dipping but not the disinhibition of open-arm avoidance
    • Dalvi A., Rodgers R.J. Behavioral effects of diazepam in the murine plus-maze: flumazenil antagonism of enhanced head dipping but not the disinhibition of open-arm avoidance. Pharmacol Biochem Behav 1999, 62(4):727-734.
    • (1999) Pharmacol Biochem Behav , vol.62 , Issue.4 , pp. 727-734
    • Dalvi, A.1    Rodgers, R.J.2
  • 46


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.