Systemic Lupus Erythematosus Patients Contain Significantly Less IgM against Mono-Methylated Lysine than Healthy Subjects

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Guo, Sha ^a   Liu, Ying ^a   Ma, Younan ^a   Zhao, Qing ^a   Zhu, Liping ^a   Shao, Yuehu ^b   Gao, Fengying ^c   Wu, Fengqi ^d   Gao, Ruitong ^e   Zhang, Wei ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b Absea Biotechnology Ltd   (China)

^c Department of Internal Medicine   (China)

^d CAPITAL INSTITUTE OF PEDIATRICS   (China)

^e PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; DOUBLE STRANDED DNA; EPITOPE; HISTONE H1; HISTONE H3; IMMUNOGLOBULIN CLASS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LIPOPOLYSACCHARIDE; LYSINE; SINGLE STRANDED DNA;

ADOLESCENT; AMINO ACID COMPOSITION; AMINO TERMINAL SEQUENCE; ARTICLE; CHILD; CONTROLLED STUDY; DISEASE ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRESCHOOL CHILD; PROTEIN PROCESSING; SCHOOL CHILD; SYSTEMIC LUPUS ERYTHEMATOSUS;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; FEMALE; HISTONES; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYSINE; MALE; METHYLATION;

EID: 84880503171     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0068520     Document Type: Article

References (48)

1. Rahman A, Isenberg DA, (2008) Systemic lupus erythematosus. N Engl J Med 358: 929-939.
2. Sherer Y, Gorstein A, Fritzler MJ, Shoenfeld Y, (2004) Autoantibody explosion in systemic lupus erythematosus: more than 100 different antibodies found in SLE patients. Semin Arthritis Rheum 34: 501-537.
3. Luger K, Mäder AW, Richmond RK, Sargent DF, Richmond TJ, (1997) Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature 389: 251-260.
4. Kornberg RD, Lorch Y, (1999) Twenty-five years of the nucleosome, fundamental particle of the eukaryote chromosome. Cell 98: 285-294.
5. Khorasanizadeh S, (2004) The nucleosome: from genomic organization to genomic regulation. Cell 116: 259-272.
6. Stummvoll GH, Fritsch RD, Meyer B, Hoefler E, Aringer M, et al. (2009) Characterisation of cellular and humoral autoimmune responses to histone H1 and core histones in human systemic lupus erythaematosus. Ann Rheum Dis 68: 110-116.
7. Kaliyaperumal A, Michaels MA, Datta SK, (2002) Naturally processed chromatin peptides reveal a major autoepitope that primes pathogenic T and B cells of lupus. J Immunol 168: 2530-2537.
8. Muller S, Bonnier D, Thiry M, Van Regenmortel MH, (1989) Reactivity of autoantibodies in systemic lupus erythematosus with synthetic core histone peptides. Int Arch Allergy Appl Immunol 89: 288-296.
9. Monestier M, Decker P, Briand JP, Gabriel JL, Muller S, (2000) Molecular and structural properties of three autoimmune IgG monoclonal antibodies to histone H2B. J Biol Chem 275: 13558-13563.
10. Schett G, Smole J, Zimmermann C, Hiesberger H, Hoefler E, et al. (2002) The autoimmune response to chromatin antigens in systemic lupus erythematosus: autoantibodies against histone H1 are a highly specific marker for SLE associated with increased disease activity. Lupus 11: 704-715.
11. Datta SK, (2003) Major peptide autoepitopes for nucleosome-centered T and B cell interaction in human and murine lupus. Ann N Y Acad Sci 987: 79-90.
12. Jenuwein T, Allis CD, (2001) Translating the histone code. Science 293: 1074-1080.
13. Strahl BD, Allis CD, (2000) The language of covalent histone modifiations. Nature 403: 41-45.
14. Kouzarides T, (2007) Chromatin modifications and their function. Cell 128: 693-705.
15. Barski A, Cuddapah S, Cui K, Roh TY, Schones DE, et al. (2007) High-resolution profiling of histone methylations in the human genome. Cell 129: 823-837.
16. Bannister AJ, Kouzarides T, (2011) Regulation of chromatin by histone modifications. Cell Res 21: 381-395.
17. Anderton SM, (2004) Post-translational modifications of self antigens: implications for autoimmunity. Curr Opin Immunol 16: 753-758.
18. Dieker J, Muller S, (2010) Epigenetic histone code and autoimmunity. Clin Rev Allergy Immunol 39: 78-84.
19. Plaué S, Muller S, van Regenmortel MH, (1989) A branched, synthetic octapeptide of ubiquitinated histone H2A as target of autoantibodies. J Exp Med 169: 1607-1617.
20. Dieker JW, Fransen JH, van Bavel CC, Briand JP, Jacobs CW, et al. (2007) Apoptosis-induced acetylation of histones is pathogenic in systemic lupus erythematosus. Arthritis Rheum 56: 1921-1933.
21. van Bavel CC, Dieker JW, Kroeze Y, Tamboer WP, Voll R, et al. (2011) Apoptosis-induced histone H3 methylation is targeted by autoantibodies in systemic lupus erythematosus. Ann Rheum Dis 70: 201-207.
22. van Bavel CC, Dieker J, Muller S, Briand JP, Monestier M, et al. (2009) Apoptosis-associated acetylation on histone H2B is an epitope for lupus autoantibodies. Mol Immunol 47: 511-516.
23. Rayzman VM, Sentry JW, (2006) MCA1 detection of histone H3 serine 10 phosphorylation, a novel biomarker for determination of mitotic indices. Hum Antibodies 15: 71-80.
24. Hochberg MC, (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40: 1725.
25. Shechter D, Dormann HL, Allis CD, Hake SB, (2007) Extraction, purification and analysis of histones. Nat Protoc 2: 1445-1457.
26. Tiller T, Meffre E, Yurasov S, Tsuiji M, Nussenzweig MC, et al. (2008) Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning. J Immunol Methods 329: 112-124.
27. Ehrenstein MR, Notley CA, (2010) The importance of natural IgM: scavenger, protector and regulator. Nat Rev Immunol 10: 778-786.
28. Lutz HU, Binder CJ, Kaveri S, (2009) Naturally occurring auto-antibodies in homeostasis and disease. Trends Immunol 30: 43-51.
29. Boes M, Schmidt T, Linkemann K, Beaudette BC, Marshak-Rothstein A, et al. (2000) Accelerated development of IgG autoantibodies and autoimmune disease in the absence of secreted IgM. Proc Natl Acad Sci U S A 97: 1184-1189.
30. Ehrenstein MR, Cook HT, Neuberger MS, (2000) Deficiency in serum immunoglobulin (Ig)M predisposes to development of IgG autoantibodies. J Exp Med 191: 1253-1258.
31. Werwitzke S, Trick D, Kamino K, Matthias T, Kniesch K, et al. (2005) Inhibition of lupus disease by anti-double-stranded DNA antibodies of the IgM isotype in the (NZB × NZW)F1 mouse. Arthritis Rheum 52: 3629-3638.
32. Mannoor K, Matejuk A, Xu Y, Beardall M, Chen C, (2012) Expression of natural autoantibodies in MRL-lpr mice protects from lupus nephritis and improves survival. J Immunol 188: 3628-3638.
33. Jiang C, Foley J, Clayton N, Kissling G, Jokinen M, et al. (2007) Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice. J Immunol 178: 7422-7431.
34. Witte T, (2008) IgM Antibodies against dsDNA in SLE. Clin Rev Allergy Immunol 34: 345-347.
35. Li QZ, Xie C, Wu T, Mackay M, Aranow C, et al. (2005) Identification of autoantibody clusters that best predict lupus disease activity using glomerular proteome arrays. J Clin Invest 115: 3428-3439.
36. Grönwall C, Akhter E, Oh C, Burlingame RW, Petri M, et al. (2012) IgM autoantibodies to distinct apoptosis-associated antigens correlate with protection from cardiovascular events and renal disease in patients with SLE. Clin Immunol 142: 390-398.
37. Sims RJ 3rd, Nishioka K, Reinberg D (2003) Histone lysine methylation: a signature for chromatin function. Trends Genet 19: 629-639.
38. Zhang X, Wen H, Shi X, (2012) Lysine methylation: beyond histones. Acta Biochim Biophys Sin (Shanghai) 44: 14-27.
39. Baumgarth N, (2011) The double life of a B-1 cell: self-reactivity selects for protective effector functions. Nat Rev Immunol 11: 34-46.
40. Zhang J, Jacobi AM, Wang T, Berlin R, Volpe BT, et al. (2009) Polyreactive autoantibodies in systemic lupus erythematosus have pathogenic potential. J Autoimmun 33: 270-274.
41. Kohm AP, Fuller KG, Miller SD, (2003) Mimicking the way to autoimmunity: an evolving theory of sequence and structural homology. Trends Microbiol 11: 101-105.
42. Sims RJ 3rd, Nishioka K, Reinberg D (2003) Histone lysine methylation: a signature for chromatin function. Trends Genet 19: 629-639.
43. Diamond B (2008) Systemic Autoimmunity. In: Paul WE editor. Fundamental Immunology, Philadelphia, USA: Lippincott Williams & Wilkins Press. 1292-1330.
44. Wardemann H, Yurasov S, Schaefer A, Young JW, Meffre E, et al. (2003) Predominant autoantibody production by early human B cell precursors. Science 301: 1374-1377.
45. Tiller T, Tsuiji M, Yurasov S, Velinzon K, Nussenzweig MC, et al. (2007) Autoreactivity in human IgG+ memory B cells. Immunity 26: 205-213.
46. Yurasov S, Wardemann H, Hammersen J, Tsuiji M, Meffre E, et al. (2005) Defective B cell tolerance checkpoints in systemic lupus erythematosus. J Exp Med 201: 703-711.
47. Mietzner B, Tsuiji M, Scheid J, Velinzon K, Tiller T, et al. (2008) Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors. Proc Natl Acad Sci U S A 105: 9727-9732.
48. Wellmann U, Letz M, Herrmann M, Angermüller S, Kalden JR, et al. (2005) The evolution of human anti-double-stranded DNA autoantibodies. Proc Natl Acad Sci U S A 102: 9258-9263.